Primary Extranodal Non-Hodgkin’s Lymphoma of Maxillary Sinus: Rare Incident

Year 2019, Volume: 2 Issue: 2, 61 - 63, 08.10.2019

Vıshnu Varathan , Mark Paul Shashi Gopalan Marimuthu Santhi Kalimuthu

Abstract

Non-Hodgkin lymphoma (NHL) commonly arises from lymphoid organ and tissues. But up to 35% of cases have been reported to primarily originate from extranodal sites. Primary paranasal sinus lymphoma accounts for 8% of all paranasal malignancies and a mere 2% of all primary extranodal lymphoma. We described a 72-year-old woman with primary extranodal diffuse large B-cell lymphoma (DLBCL) originated from maxillary sinus extended into adjacent sinuses and structures. She presented with painful, numb, vague, diffuse, hard swelling over right medial canthus since two months. There was no diplopia. She had right epiphora since two weeks. Minimal proptosis was seen in the right eye. There was no history of foul smelling nasal discharge or obstruction. There was no neck swelling. She did not have underlying comorbid illnesses. Rigid nasal endoscopy revealed a friable mass arising from the right osteomeatal complex (OMC) occupying the entire right side of nasopharynx. Computed tomography (CT) revealed a soft tissue mass occupying the entire right maxillary sinus extending into adjacent structures. Treatment was completed and patient remained in remission. Features pertaining to demographic, markers, treatment regimes, and outcomes are discussed in detail.

Keywords

Maxillary diseases , maxillary sinus neoplasms , lymphoma , Non-Hodgkin

References

• Newton R, Ferlay J, Beral V, Devesa SS. The epidemiology of non-Hodgkin’s lymphoma: Comparison of nodal and extra-nodal sites. Int J Cancer 1997; 72: 923-30.
• Catalfamo L, Nava C, Matyasova J, De Ponte FS. Primary Diffuse Large B-Cell Lymphoma of the Ethmoido-Orbital Region. J Craniofac Surg 2013; 24: 602-4.
• Yoon YH, Park WY, Choi YJ, Cho KS. Synchronous, primary, diffuse, large B-cell lymphomas involving the ethmoid sinus and epiglottis: a rare clinical entity. Laryngoscope 2013; 123: 702-4.
• Doumas S, Sakkas L, Panayiotidis P, Wozniak G, Vlychou M, Vassilopoulos G. Favorable outcome in non-Hodgkin lymphoma of the maxillary sinus treated with R-CHOP. Arch Med Sci 2014; 10: 406-9.
• Buchanan A, Kalathingal S, Capes J, Kurago Z. Unusual presentation of extranodal diffuse large B-cell lymphoma in the head and neck: description of a case with emphasis on radiographic features and review of the literature. Dentomaxillofac Radiol 2015; 44: doi: 10.1259/dmfr.20140288.
• Adwani DG, Arora RS, Bhattacharya A, Bhagat B. Non-Hodgkin’s lymphoma of maxillary sinus: An unusual presentation. Ann Maxillofac Surg 2013; 3: 95-7.
• Oprea C, Cainap C, Azoulay R, Assaf E, Jabbour E, Koscielny S, et al. Primary diffuse large B-cell non-Hodgkin lymphoma of the paranasal sinuses: a report of 14 cases. Br J Haematol 2005; 131: 468-71.