Abstract
Wegener’s granulomatosis is an idiopathic necrotizing granulatous vasculitis that can hold small and medium arteries, upper respiratory tract, lung and kidney involvement. It’s an ANCA associated vasculitis. c-ANCA positivity is considered very sensitive. In our case, a 40-year-old female patient was admitted to our hospital with complaints of nasal bleeding and crusting. The patient was operated due to idiopathic nasal septal perforation, was seen saddle nose deformity and 3x4 cm in size perforation in anterior septum and 1x2 cm in size perforation in posterior septum. Nasal biopsies of the patient with C-ANCA positivity were taken and the result of pathology came in harmony with Wegener’s granulomatosis. The patient was directed to the related clinic for the treatment of Wegener’s granulomatosis. Wegener Granulomatosis, which enters the diagnosis of idiopathic nasal septal perforation, is a disease that should be kept in mind.
References
- Reinhold-Keller E, Beuge N, Latza U, de Groot K, Rudert H, Nolle B, et al. An interdisciplinary approach to the care of patients with Wegener’s granulomatosis: long-term outcome in 155 patients. Arthritis Rheum 2000; 43: 1021-32.
- Perincek G, Tabakoğlu E, Pamuk Ö.N. Massive Alveolar Hemorrhage During Wegener Granulomatosis: a Case Report. Balkan Med J 2011; 28: 463-65.
- Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med 2004; 117: 39-50.
- Srouji IA, Andrews P, Edwards C, Lund VJ. Patterns of presentation and diagnosis of patients with Wegener’s granulomatosis: ENT aspects. J Laryngol Otol 2007; 121: 653-8.
- Janisiewicz AM, Klau MH, Keschner DB, Lehmer RR, Venkat KV, Medhekar SS, et al. Higher antineutrophil cytoplasmic antibody (C-ANCA) titers are associated with increased overall healthcare use in patients with sinonasal manifestations of granulomatosis with polyangiitis(GPA). Am J Rhinol Allergy. 2015; 29: 202-6.
- Gubbels SP, Barkhuizen A, Hwang PH. Head and neck manifestations of Wegener’s granulomatosis. Otolaryngol Clin North Am 2003; 36: 685-705.
- Rasmussen N. Management of the ear, nose, and throat manifestations of Wegener granulomatosis: an otorhinolaryngologist’s perspective. Curr Opin Rheumatol 2001; 13: 3-11.
- Van der Woude FJ, Rasmussen N, Lobatto S. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet 1985; 1: 425-42.
- Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granulomatosis: An analysis of 158 patients. Ann Intern Med 1992; 116: 488-98.
- Siomou E, Tramma D, Bowen C, Milford DV. ANCA-associated glomerulonephritis/systemic vasculitis in childhood: clinical features-outcome. Pediatr Nephrol 2012; 27: 1911-20.
- Erickson VR, Hwang PH. Wegener’s granulomatosis: current trends in diagnosis and management. Curr Opin Otolaryngol Head Neck Surg 2007; 15: 170-6.
- Falk RJ, Jennette JC. Wegener’s granulomatosis, systemic vasculitis, and antineutrophil cytoplasmic autoantibodies. Annu Rev Med 1991; 42: 459-69.
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Case Report |
| Authors | |
| Publication Date | March 6, 2019 |
| Published in Issue | Year 2018 Volume: 1 Issue: 3 |
Cite
You can find the current version of the Instructions to Authors at: https://www.eurjrhinol.org/en/instructions-to-authors-104
Starting on 2020, all content published in the journal is licensed under the Creative Commons Attribution-NonCommercial (CC BY-NC) 4.0 International
License which allows third parties to use the content for non-commercial purposes as long as they give credit to the original work. This license
allows for the content to be shared and adapted for non-commercial purposes, promoting the dissemination and use of the research published in
the journal.
The content published before 2020 was licensed under a traditional copyright, but the archive is still available for free access.