Abstract

Amaç: Bu çalışmada acil servise başvuran organofosfat zehirlenmesi (OP) ile başvuran hastalarda morbidite ve mortalitenin ciddiyetinin belirlenmesinde magnezyum, nötrofil / lenfosit oranlarının (NLR) prediktif değerini araştırmak amaçlanmıştır.

Gereç ve Yöntem: Bu çalışma 2010-2015 yılları arasında OP ile acil servise başvuran 18 yaş üstü hastaların tıbbi kayıtları retrospektif taranarak yapıldı. Hastaların Demografik özellikler, tıbbi öykü, laboratuvar bulguları ve Glasgow Koma Skalası (GKS) skorları kaydedildi.

Bulgular: 91 erkek ve 62 kadın 153 hastanın verileri değerlendirildi. OP’li hastalarda magnezyum, hemoglobin, hematokrit, lökositoz, trombosit, potasyum, kalsiyum, glukoz, alanin aminotransferaz (ALT), troponin ve mortalite değişiklikleri arasında anlamlı bir ilişki bulunmadı (p> 0.05). Laktat dehidrojenaz artışı (LDH) (p = 0.004), düşük lenfosit sayısı (p = 0.003), azalmış kolinesteraz (p = 0.001), yüksek NLR düzeyi (p = 0.002), GKS (p<0.001) mekanik ventilatör (MV) gereksinimi (p <0.001), yaş (P = 0.009), vazopressör tedavisi (p <0.001) ve mortalite arasında anlamlı bir ilişki vardı.

Sonuç: Magnezyum düzeyleri ile prognoz arasında anlamlı bir ilişki bulunamamıştır. OP’li hastalarda düşük lenfosit sayısı, azalmış kolinesteraz, LDH ve NLR artışı mortalite ile anlamlı olarak korele idi. Rutin hemogramlardaki parametrelerden biri olan artmış NLR oranı, OP hastalarının uzun süreli takibi hakkında hekimlere bilgi verebilir.  

Keywords

• acil,organofosfat,magnezyum,nötrofil lenfosit oranı

The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning

Abstract

Objectives: To investigate the predictive value of magnesium, neutrophil/lymphocyte ratios (NLR) in determining the severity of morbidity and mortality

in patients with organophosphate poisoning (OP) admitted to the emergency department.

Materials ad Methods: This study was conducted retrospectively by scanning the medical recordings of patients aged over 18 years who were admitted

to our emergency department with OP between 2010 and 2015. The demographic characteristics, medical history, laboratory findings, and Glasgow Coma

Scale (GCS) scores of the patients were recorded.

Results: The data of 153 patients, 91 males and 62 females, were evaluated. There was no significant correlation between the changes in magnesium,

hemoglobin, hematocrit, leukocytosis, platelets, potassium, calcium, glucose, alanine aminotransferase (ALT), troponin, and mortality in patients with OP

(p>0.05). There was a significant relationship between the increase in lactate dehydrogenase (LDH) (p=0.004), low lymphocyte count (p=0.003), decreased

cholinesterase (p=0.001), higher (NLR) (p=0.002), GCS (p<0.001), mechanical ventilator (MV) requirement (p<0.001), age (P=0.009), vasopressor treatment

(p<0.001), and mortality.

Conclusion: No significant relationship determined between magnesium levels and prognosis. Low lymphocyte count, decreased cholinesterase, increased

LDH and NLR in patients with OP were significantly correlated with mortality. Increased NLR ratio, one of the parameters in routine hemograms, may give

information to physicians about the long-term follow-up of such patients with OP.

Keywords

• Emergency,Organophosphate,Magnesium,Neutrophil lymphocyte ratio

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