Evaluation of the Relationship of Serum Digoxin Levels with Demographic Data
Abstract
Objective: We aimed to compare patients presenting with digoxin intoxication clinic with serum digoxin levels with demographic data.
Materials and Methods: This is a retrospective study. Patients admitted to the emergency room with suspected digoxin intoxication included into the study. Patients with missed data, and patients younger than 18 years were excluded. Statistical analysis was performed using the SPSS v25 (SPSS Inc, Chicago, IL) program package.
Results: A total of 118 patients were investigated in our retrospective study. Among these, 38 (%32,2) were men and 80 were female (%67,8). Patients with a digoxin level above 2 were evaluated for intoxication. Digoxin intoxication was detected in 31 patients (26.3%). Of 31 patients with digoxin intoxication, 19 (61.2%) were hospitalized. Patients who had digoxin intoxication admission complaints were fatigue in 6 patients (19,35%), nausea in 4 patients (12,9%), bradycardia in 4 patients (12,9%), and general condition disorder in 4 patients (12,9%).
Conclusion: Blood level in digoxin
intoxication may not always be decisive.
After a detailed anamnesis, physical examination, ECG findings should be
followed, routine electrolyte and other blood tests should be examined and
cardiology should be consulted.
Keywords
References
- 1) Ochs HR, Grube E, Greenblatt DJ, Arendt R, Bodem G. Pharmacokinetics and pharmacodynamics of intravenous digoxin and digitoxin. Klinische Wochenschrift, 1981; 59(16):889-97.
- 2) Kayaalp O. Medical Pharmacology for Rational Therapy (10th edition). Ankara: Hacettepe-Taş Kitapçılık. 2002.
- 3) Kepez A, Kabakcı G. Treatment of Heart Failure, Hacettepe Medical Journal, 2004; 35 (2):69-81.
- 4) Çiftçi E, Aydın S. Toxicological Evaluation of Digital Glycosides in Congestive Heart Failure, FABAD J. Pharm. Sci, 2018; 43(3):263-77.
- 5) Dec G W. Digoxin Remains Useful in the Management of Chronic Heart Failure, The Medical Clinics of North America, 2003; 87 (2):317-37.
- 6) Satar S, Acilde Klinik Toksikoloji. Akademisyen Kitabevi. Ankara, Türkiye, 2009.
- 7) Vyas A, Bachani N, Thakur H, Lokhandwala Y. Digitalis toxicity: ECG vignette. Indian Heart Journal, 2016; 68(2):223-5.
- 8) Boyle JS, Kirk MA. Digitalis Glycosides. In:Tintinalli JE, Tintinalli's Emergency Medicine, A Comprehensive Study Guide, seventh edition, New York, McGraw Hill, 2010:1260-4.
Details
Primary Language
English
Subjects
Toxicology, Emergency Medicine
Journal Section
Research Article
Authors
Hatice Şeyma Akça
0000-0003-2823-9577
Türkiye
Abdullah Algın
*
0000-0002-9016-9701
Türkiye
Serdar Özdemir
0000-0002-6186-6110
Türkiye
Kamil Kokulu
0000-0002-6132-0898
Türkiye
İbrahim Altunok
0000-0002-9312-1025
Türkiye
Publication Date
July 17, 2019
Submission Date
May 25, 2019
Acceptance Date
July 4, 2019
Published in Issue
Year 2019 Volume: 1 Number: 2