Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Year 2020, Volume: 3 Issue: 2, 80 - 85, 31.10.2020

Negar Khezri E. Vildan Burgaz

Abstract

“Ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery.
Manganese(III) acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” by the multi-steps reaction of ethyl 3,3-bis(4-fluorophenyl)acrylate and 4-hydroxycoumarin under microwave irradiation to perform faster heating times, significantly reduce reaction times, and the efficient solubilization of manganese(III) acetate in acetic acid. The cyclization reaction was achieved using reactivity of the carbonyl group within the molecule.

Keywords

Radical Cyclization Reaction , Manganese (III) Acetate , Dihydrofuran , Microwave irradiation

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