Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review

Year 2024, Volume: 7 Issue: 2, 68 - 79, 28.11.2024

Ülfet Güdül , Hananeh Kordbacheh , Sonia Sanajou , Gönül Şahin

https://doi.org/10.54994/emujpharmsci.1536853

Abstract

Chronotoxicity evaluates the time-dependent toxicity of xenobiotics together with an individual’s circadian rhythm. Suprachiasmatic nuclei located in the hypothalamus regulate circadian rhythms in individuals. Circadian rhythms are important for human health, metabolic processes, inflammation, and various cancers. This comprehensive review aims to provide an overview of the literature on chronotoxicity, circadian pharmacokinetics, and chronoefficiency. Our literature search was conducted using databases including “Web of Science,” “PubMed,” and “Science Direct.” We used the keywords “circadian rhythm dysregulation,” “chronotoxicity of therapeutics,” “chronotoxicity,” and “time-dependent toxicity” for our literature search. Chronopharmacokinetics studies pharmacokinetic changes related to dosage time. Light plays an important role in circadian rhythm by stimulating ganglion cells. The stimulus is transferred to the suprachiasmatic nuclei and other parts of the brain that regulate the circadian rhythm. Evaluation of the risks and benefits of various therapeutic options requires detailed knowledge of the complex mechanisms that regulate circadian rhythms.

Keywords

Chronotoxicity, chronopharmacokinetic, chronotherapeutics, chronoefficacy, circadian rhythms

References

• Albrecht U (2020). Molecular connections between circadian clocks and mood-related behaviors. J Mol Biol 432(12): 3714-3721.
• Ayyar VS, Sukumaran S (2021). Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions. J Pharmacokinet Pharmacodyn 48:321-338.
• Bicker J, Alves G, Falcão A, Fortuna A (2020). Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics. Br J Pharmacol 177(10):2215-2239.
• Bielefeld EC, Markle A, DeBacker JR, Harrison RT (2018). Chronotolerance for cisplatin ototoxicity in the rat. Hear Res 370:16-21.
• Bonten TN, Saris A, van Oostrom MJ, Snoep JD, Rosendaal FR, Zwaginga JJ, van der Bom JG (2014). Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. JTH 112(12):1209-1218.
• Bouali I, Dridi I, Gadacha W, Aouam K, Hassine M, El-Bok S, Souli A (2023). Circadian variation in hematotoxicity of the antineoplastic agent “5 Fluorouracil (5 FU)” in female rats and its relevance to chronotherapy. Biol Rhythm Res 54(4): 419-436.
• Boughattas NA, Hecquet B, Fournier C, Bruguerolle B, Trabelsi H, Bouzouita K, Lévi F (1994). Comparative pharmacokinetics of oxaliplatin (L‐OHP) and carboplatin (CBDCA) in mice with reference to circadian dosing time. BDDCS 15(9): 761-773.
• Bruguerolle B, Valli M, Bouyard L, Jadot G, Bouyard P(1983). Effect of the hour of administration on the pharmacokinetics of lidocaine in the rat. Eur J Drug Metab Pharmacokinet 8:233-238.
• Budkowska M, Cecerska-Heryć E, Marcinowska Z, Siennicka A, Dołęgowska B (2022). The influence of circadian rhythm on the activity of oxidative stress enzymes. Int J Mol Sci 23(22): 14275.
• Buurma M, Van Diemen JJ, Thijs A, Numans ME, Bonten TN (2019). Circadian rhythm of cardiovascular disease: the potential of chronotherapy with aspirin. Front cardiovasc med 6:84.
• Clairambault J (2007). Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance. Adv Drug Deliv Rev 59(9-10): 1054-1068.
• Cardinali DP, Garay A (2023). Melatonin as a chronobiotic/cytoprotective agent in REM sleep behavior disorder. Brain Sci 13(5): 797.
• Dong D, Yang, D, Lin L, Wang S, Wu B (2020). Circadian rhythm in pharmacokinetics and its relevance to chronotherapy. Biochem Pharmacol 178:114045.
• Dulong S, de Souza LEB, Machowiak J, Peuteman B, Duvallet G, Boyenval D, Ballesta A (2022). Sex and circadian timing modulate oxaliplatin hematological and hematopoietic toxicities. Pharm 14(11):2465.
• Emmer KM, Russart KL, Walker II WH, Nelson RJ, DeVries AC (2018). Effects of light at night on laboratory animals and research outcomes. Behav Neurosci 132(4): 302.
• Erkekoglu P, Baydar T (2012). Chronopharmacokinetics of drugs in toxicological aspects: a short review for pharmacy practitioners. JRPP 1(1): 3-9.
• Fernandez E, Perez R, Hernandez A, Tejada P, Arteta M, Ramos JT (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharm 3(1): 53-72.
• Jacob H, Curtis AM, Kearney CJ (2020). Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases. Biochem Pharmacol 182:114254.
• Kaur G, Phillips C, Wong K, Saini B (2013). Timing is important in medication administration: a timely review of chronotherapy research. Int J Clin Pharm 35:344-358.
• Koopman MG, Koomen, GC, Krediet RT, De Moor EA, Hoek FJ, Arisz L (1989). Circadian rhythm of glomerular filtration rate in normal individuals. Clin Sci 77(1): 105-111.
• Korenčič A, Košir R, Bordyugov G, Lehmann R, Rozman D, Herzel H (2014). Timing of circadian genes in mammalian tissues. Sci Rep 4(1): 5782.
• Koyanagi S (2021). Chrono-pharmaceutical approaches to optimize dosing regimens based on the circadian clock machinery. Biol Pharm Bull 44(11): 1577-1584.
• Krasińska B, Paluszkiewicz L, Miciak-Ławicka E, Krasinski M, Rzymski P, Tykarski A, Krasiński Z (2021). The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial. Eur J Clin Pharmacol 77:35-43.
• Levi F, Schibler U (2007). Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol 47(1): 593-628.
• Lin Y, Wang S, Zhou Z, Guo L, Yu F, et al. (2019). Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Commun Biol 2(1): 378.
• Ma L, Yu F, He D, Guo L, Yang Y, et al. (2023). Role of circadian clock in the chronoefficacy and chronotoxicity of clopidogrel. Br J Pharmacol 180(23): 2973-2988.
• Maeda K, Shibutani M, Otani H, Fukuoka T, Iseki Y, et al. (2018). Neoadjuvant radiotherapy with capecitabine plus bevacizumab for locally advanced lower rectal cancer: results of a single-institute phase II study. Anticancer Res 38(7): 4193-4197.
• Mak SSS, Hui P E, Wan WMR, Yih CLP (2020). At-home chemotherapy infusion for patients with advanced cancer in Hong Kong. HKJR 23(2): 122.
• Mason IC, Qian J, Adler GK, Schee FA (2020). Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia 63(3): 462-472.
• Mohd Azmi NAS, Juliana N, Azmani S, Mohd Effendy N, Abu I F, et al. (2021). Cortisol on circadian rhythm and its effect on cardiovascular system. Int J Environ Res Public Health 18(2): 676.
• Ohdo S (2010). Chronotherapeutic strategy: rhythm monitoring, manipulation and disruption. Adv. Drug Deliv Rev 62(9-10): 859-875.
• Okyar A, Ozturk Civelek D, Akyel YK, Surme S, Pala Kara Z, et al. (2024). The role of the circadian timing system on drug metabolism and detoxification: an update. Expert Opin Drug Metab Toxicol 5(9): 867-910
• Sukumaran S, Almon RR, DuBois DC, Jusko WJ (2010). Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv Drug Deliv Rev 62(9-10): 904-917.
• Zuber AA, Centeno G, Pradervand S, Nikolaeva S, Maquelin L, et al. (2009). Molecular clock is involved in predictive circadian adjustment of renal function. PNAS 106(38): 16523-16528.