Tinnitus hastalarında nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi

Öz

Amaç: Bu retrospektif, olgu-kontrol çalışmasının amacı, nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama trombosit hacmi ile tinnitus arasındaki ilişkiyi araştırmaktır.

Yöntem: Çalışmaya 51 tinnitus hastası ile 42 yaş ve cinsiyet uyumlu sağlıklı kontrol hastası alındı. Hastaların medikal kayıtlarından saf ses ortalamasını da içeren odyometrik bilgileri, tinnitusun yönü, ne kadar süredir var olduğu, tinnitus reaksiyon anketi, tinnitus handikap anketi, tam kan sayımı ve biyokimya değerleri kaydedildi. Ortalama nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama trombosit hacmi tinnitus hastaları ve sağlıklı kontroller arasında karşılaştırıldı.

Bulgular: Ortalama kan nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama trombosit hacmi bakımından tinnitus hastaları ve sağlıklı kontroller arasında anlamlı fark saptanmadı.

Sonuç: Kan nötrofil/lenfosit oranı, platelet/lenfosit oranı ve ortalama trombosit hacmi tinnitus hastalarının rutin klinik değerlendirmesinde yararlı parametreler olmayabilir.

Anahtar sözcükler: Tinnitus, nötrofiller, lenfositler, ortalama trombosit hacmi.

Anahtar Kelimeler

• Tinnitus, nötrofiller, lenfositler, ortalama trombosit hacmi

Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

Abstract

Objective: The aim of this retrospective, case-control study was to investigate the association of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) with tinnitus. Methods: A total of 51 patients with tinnitus and 42 healthy, age- and sex-matched subjects were recruited for the present study. Audiometric data including pure-tone average (PTA) values, the side of the head in which tinnitus was experienced, duration of tinnitus, tinnitus reaction questionnaire (TRQ), tinnitus handicap questionnaire (THQ), complete blood count (CBC) and biochemical data were assessed from patient records. The mean values of NLR, PLR and MPV were compared between patients with tinnitus and healthy controls. Results: The difference was not significant for mean serum NLR, PLR and MPV values between patients with tinnitus and healthy controls

Keywords

• Tinnitus,neutrophils,lymphocytes,mean platelet volume

References

1. Henry JA, Dennis KC, Schechter MA. General review of tinni- tus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res 2005;48:1204–35.
2. Ferroni P, Riondino S, Formica V, et al. Venous thromboem- bolism risk prediction in ambulatory cancer patients: clinical sig- nificance of plate/lymphocyte ratio and platelet/lymphocyte ratio. Int J Cancer 2015;136:1234–40.
3. Chung JH, Lim J, Jeong JH, Kim KR, Park CW, Lee SH. The significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in vestibular neuritis. Laryngoscope 2015;125: E257–61.
4. Bucak A, Ulu S, Oruc S, et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678–81.
5. Volume5 |Issue3 |December2015 105
6. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diag- nosis and prognosis in patients with idiopathic sudden sen- sorineural hearing loss. Dis Markers 2014;2014:702807.
7. Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg 2013;65:350–3.
8. Wilson PH, Henry J, Bowen M, Haralambous G. Tinnitus reac- tion questionnaire: psychometric properties of a measure of dis- tress associated with tinnitus. J Speech Hear Res 1991;34:197– 201.

9. Kuk FK, Tyler RS, Russell D, Jordan H. The psychometric properties of a tinnitus handicap questionnaire. Ear Hear 1990; 11:434–45.
10. Kim DK, Chung DY, Bae SC, Park KH, Yeo SW, Park SN. Diagnostic value and clinical significance of stress hormones in patients with tinnitus. Eur Arch Otorhinolaryngol 2014;271: 2915–21.
11. Langguth B, Landgrebe M, Kleinjung T, Sand GP, Hajak G. Tinnitus and depression. World J Biol Psychiatry 2011;12: 489–500.
12. Joos K, Vanneste S, De Ridder D. Disentangling depression and distress networks in the tinnitus brain. PLoS One 2012;7:e40544. doi:10.1371/journal.pone.0040544
13. Gomaa MA, Elmagd MH, Elbadry MM, Kader RM. Depression, Anxiety and Stress Scale in patients with tinnitus and hearing loss. Eur Arch Otorhinolaryngol 2014;271:2177–84.
14. Rohleder N. Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med 2014;76:181–9.
15. Tefferi A, Hanson CA, Inwards DJ. How to interpret and pur- sue an abnormal complete blood cell count in adults. Mayo Clin Proc 2005;80:923–36.
16. Azab B, Bhatt VR, Phookan J, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting short- and long-term mortali- ty in breast cancer patients. Ann Surg Oncol 2012;19:217–24.
17. Jung MR, Park YK, Jeong O, et al. Elevated preoperative neu- trophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol 2011;104:504–10.
18. Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol 2011;107:433–8.
19. Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relation- ship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail 2012;34:155–9.
20. Torun S, Tunc BD, Suvak B, et al. Assessment of neutrophil- lymphocyte ratio in ulcerative colitis: a promising marker in pre- dicting disease severity. Clin Res Hepatol Gastroenterol 2012;36:491–7.
21. Bialas M, Taran K, Gryszkiewicz M, Modzelewski B. Evaluation of neutrophil-lymphocyte ratio usefulness in the diagnosis of appendicitis. [Article in Polish] Wiad Lek 2006;59:601–6.
22. Rachidi S, Wallace K, Wrangle JM, Day TA, Alberg AJ, Li Z. Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma. Head Neck 2015. doi: 10.1002/hed.24159
23. Ozbay I, Kahraman C, Balikci HH, et al. Neutrophil-to-lym- phocyte ratio in patients with severe tinnitus: prospective, con- trolled clinical study. J Laryngol Otol 2015;129:544–7.
24. Atan D, İkincioğulları A, Köseoğlu S, et al. New predictive parameters of Bell’s palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 2015;32:167–70.
25. Atan D, Özcan KM, Köseoğlu S, et al. New predictive parame- ters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2015;25:97–101.
26. Turkmen K, Erdur FM, Ozcicek F, et al. Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lympho- cyte ratio in end-stage renal disease patients. Hemodial Int 2013;17:391–6.
27. Que Y, Qiu H, Li Y, et al. Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma. BMC Cancer 2015;15:648.
28. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47–58.
29. Verdoia M, Camaro C, Barbieri L, et al. Mean platelet volume and the risk of periprocedural myocardial infarction in patients undergoing coronary angioplasty. Atherosclerosis 2013;228:136–41.
30. Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cere- brovascular events? Stroke 2004;35:1688–91.
31. Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets 2013;24: 590–3.
32. Poorey VK, Thakur P. Effect of deviated nasal septum on mean platelet volume: a prospective study. Indian J Otolaryngol Head Neck Surg 2014;66:437–40.
33. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
34. NC-ND3.0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
35. tion in any medium, provided the original work is properly cited.
36. Please cite this article as: Bayram A, Yaşar M, Doğan M, Güneri E, Özcan İ. Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio
37. and mean platelet volume in patients with tinnitus. ENT Updates 2015;5(3):103–106.