Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck

Erdoğan Özgür; Barış Karakullukçu; Görkem Eskiizmir

doi:10.32448/entupdates.536860

Review

Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck

Year 2019, , 25 - 33, 19.03.2019

Erdoğan Özgür , Barış Karakullukçu Görkem Eskiizmir

https://doi.org/10.32448/entupdates.536860

Abstract

Cutaneous malignant melanoma is potentially an important health problem for white people. The incidence of melanoma is rising faster than other solid cancers. Despite the new melanoma drugs surgery for localised melanoma and regional metastasis is still the standard of care. However, management of cutaneous melanoma differs from other cancers at some points such as biopsy technique, surgical margine, incorporation ofsentinel lymph node biopsy for staging etc. In this review, we focused on the role of the head and neck surgeon in the management of cutaneous melanoma of head and neck region according to current knowledge.

Keywords

Melanoma, head and neck neoplasms, surgery, sentinel lymph node biopsy

References

1. Boring CC, Squires TS, Tong T, Montgomery S. Cancer statistics, 1994. CA Cancer J Clin 1994;44(1):7-26.
2. Leiter U, Garbe C. Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. Adv Exp Med Biol 2008;624:89-103. doi: 10.1007/978-0-387-77574-6_8
3. Whiteman DC, Green AC, Olsen CM. The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031. J Invest Dermatol 2016;136(6):1161-71. doi: 10.1016/j.jid.2016.01.035
4. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65(2):87-108. doi: 10.3322/caac.21262
5. Hacıkamiloğlu E, Gültekin M, Boztaş G, et al. Türkiye Kanser İstatistikleri. Ankara: T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu; 2017. Available from: https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/2014-RAPOR._uzuuun.pdf.
6. Chen ST, Geller AC, Tsao H. Update on the Epidemiology of Melanoma. Curr Dermatol Rep 2013;2(1):24-34. doi: 10.1007/s13671-012-0035-5
7. McGovern VJ, Mihm MC, Jr., Bailly C, et al. The classification of malignant melanoma and its histologic reporting. Cancer 1973;32(6):1446-57.
8. Amin MB, American Joint Committee on Cancer., American Cancer Society. AJCC cancer staging manual. Eight edition / editor-in-chief, Mahul B. Amin, MD, FCAP ; editors, Stephen B. Edge, MD, FACS and 16 others ; Donna M. Gress, RHIT, CTR - Technical editor ; Laura R. Meyer, CAPM - Managing editor. ed. Chicago IL: American Joint Committee on Cancer, Springer; 2017. p. xvii, 1024 pages.
9. Elder DE. Precursors to melanoma and their mimics: nevi of special sites. Mod Pathol 2006;19 Suppl 2:S4-20. doi: 10.1038/modpathol.3800515
10. Salerni G, Carrera C, Lovatto L, et al. Characterization of 1152 lesions excised over 10 years using total-body photography and digital dermatoscopy in the surveillance of patients at high risk for melanoma. J Am Acad Dermatol 2012;67(5):836-45. doi: 10.1016/j.jaad.2012.01.028
11. Network NCC. Melanoma (Version 2.2018) 2018 [08.06.2018]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf.
12. Cangiarella J, Symmans WF, Shapiro RL, et al. Aspiration biopsy and the clinical management of patients with malignant melanoma and palpable regional lymph nodes. Cancer 2000;90(3):162-6.
13. Cha J, Kim S, Wang J, Yun M, Cho A. Evaluation of (18)F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma. Nucl Med Mol Imaging 2018;52(1):39-45. doi: 10.1007/s13139-017-0495-4
14. Gold JS, Jaques DP, Busam KJ, Brady MS, Coit DG. Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a positive sentinel lymph node biopsy. Ann Surg Oncol 2007;14(7):2133-40. doi: 10.1245/s10434-007-9399-3
15. Balch CM, Urist MM, Karakousis CP, et al. Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm). Results of a multi-institutional randomized surgical trial. Ann Surg 1993;218(3):262-7; discussion 7-9.
16. Cohn-Cedermark G, Rutqvist LE, Andersson R, et al. Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8-2.0 mm. Cancer 2000;89(7):1495-501.
17. Haigh PI, DiFronzo LA, McCready DR. Optimal excision margins for primary cutaneous melanoma: a systematic review and meta-analysis. Can J Surg 2003;46(6):419-26.
18. Veronesi U, Cascinelli N, Adamus J, et al. Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm. N Engl J Med 1988;318(18):1159-62. doi: 10.1056/NEJM198805053181804
19. Eskiizmir G, Gencoglan G, Temiz P, Hircin Z, Ermertcan A. Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose. Eur Arch Otorhinolaryngol 2011;268(1):117-21. doi: 10.1007/s00405-010-1324-x
20. Moyer JS, Rudy S, Boonstra PS, et al. Efficacy of Staged Excision With Permanent Section Margin Control for Cutaneous Head and Neck Melanoma. JAMA Dermatol 2017;153(3):282-8. doi: 10.1001/jamadermatol.2016.4603
21. Gershenwald JE, Scolyer RA, Hess KR, et al. Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67(6):472-92. doi: 10.3322/caac.21409
22. Pathak I, O'Brien CJ, Petersen-Schaeffer K, et al. Do nodal metastases from cutaneous melanoma of the head and neck follow a clinically predictable pattern? Head Neck 2001;23(9):785-90.
23. Thom JJ, Moore EJ, Price DL, Kasperbauer JL, Starkman SJ, Olsen KD. The Role of Total Parotidectomy for Metastatic Cutaneous Squamous Cell Carcinoma and Malignant Melanoma. JAMA Otolaryngol Head Neck Surg 2014;140(6):548-54. doi: 10.1001/jamaoto.2014.352
24. Agrawal S, Kane JM, 3rd, Guadagnolo BA, Kraybill WG, Ballo MT. The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer 2009;115(24):5836-44. doi: 10.1002/cncr.24627
25. Morton DL, Thompson JF, Cochran AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 2006;355(13):1307-17. doi: 10.1056/NEJMoa060992
26. Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014;370(7):599-609. doi: 10.1056/NEJMoa1310460
27. Sladden M, Zagarella S, Popescu C, Bigby M. No survival benefit for patients with melanoma undergoing sentinel lymph node biopsy: critical appraisal of the Multicenter Selective Lymphadenectomy Trial-I final report. Br J Dermatol 2015;172(3):566-71. doi: 10.1111/bjd.13675
28. de Rosa N, Lyman GH, Silbermins D, et al. Sentinel node biopsy for head and neck melanoma: a systematic review. Otolaryngol Head Neck Surg 2011;145(3):375-82. doi: 10.1177/0194599811408554
29. Miller MW, Vetto JT, Monroe MM, Weerasinghe R, Andersen PE, Gross ND. False-negative sentinel lymph node biopsy in head and neck melanoma. Otolaryngol Head Neck Surg 2011;145(4):606-11. doi: 10.1177/0194599811411878
30. Bilimoria KY, Balch CM, Bentrem DJ, et al. Complete lymph node dissection for sentinel node-positive melanoma: assessment of practice patterns in the United States. Ann Surg Oncol 2008;15(6):1566-76. doi: 10.1245/s10434-008-9885-2
31. Leiter U, Stadler R, Mauch C, et al. Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol 2016;17(6):757-67. doi: 10.1016/S1470-2045(16)00141-8
32. Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med 2017;376(23):2211-22. doi: 10.1056/NEJMoa1613210

Year 2019, , 25 - 33, 19.03.2019

Erdoğan Özgür , Barış Karakullukçu Görkem Eskiizmir

https://doi.org/10.32448/entupdates.536860

Abstract

References

1. Boring CC, Squires TS, Tong T, Montgomery S. Cancer statistics, 1994. CA Cancer J Clin 1994;44(1):7-26.
2. Leiter U, Garbe C. Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. Adv Exp Med Biol 2008;624:89-103. doi: 10.1007/978-0-387-77574-6_8
3. Whiteman DC, Green AC, Olsen CM. The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031. J Invest Dermatol 2016;136(6):1161-71. doi: 10.1016/j.jid.2016.01.035
4. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65(2):87-108. doi: 10.3322/caac.21262
5. Hacıkamiloğlu E, Gültekin M, Boztaş G, et al. Türkiye Kanser İstatistikleri. Ankara: T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu; 2017. Available from: https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/2014-RAPOR._uzuuun.pdf.
6. Chen ST, Geller AC, Tsao H. Update on the Epidemiology of Melanoma. Curr Dermatol Rep 2013;2(1):24-34. doi: 10.1007/s13671-012-0035-5
7. McGovern VJ, Mihm MC, Jr., Bailly C, et al. The classification of malignant melanoma and its histologic reporting. Cancer 1973;32(6):1446-57.
8. Amin MB, American Joint Committee on Cancer., American Cancer Society. AJCC cancer staging manual. Eight edition / editor-in-chief, Mahul B. Amin, MD, FCAP ; editors, Stephen B. Edge, MD, FACS and 16 others ; Donna M. Gress, RHIT, CTR - Technical editor ; Laura R. Meyer, CAPM - Managing editor. ed. Chicago IL: American Joint Committee on Cancer, Springer; 2017. p. xvii, 1024 pages.
9. Elder DE. Precursors to melanoma and their mimics: nevi of special sites. Mod Pathol 2006;19 Suppl 2:S4-20. doi: 10.1038/modpathol.3800515
10. Salerni G, Carrera C, Lovatto L, et al. Characterization of 1152 lesions excised over 10 years using total-body photography and digital dermatoscopy in the surveillance of patients at high risk for melanoma. J Am Acad Dermatol 2012;67(5):836-45. doi: 10.1016/j.jaad.2012.01.028
11. Network NCC. Melanoma (Version 2.2018) 2018 [08.06.2018]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf.
12. Cangiarella J, Symmans WF, Shapiro RL, et al. Aspiration biopsy and the clinical management of patients with malignant melanoma and palpable regional lymph nodes. Cancer 2000;90(3):162-6.
13. Cha J, Kim S, Wang J, Yun M, Cho A. Evaluation of (18)F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma. Nucl Med Mol Imaging 2018;52(1):39-45. doi: 10.1007/s13139-017-0495-4
14. Gold JS, Jaques DP, Busam KJ, Brady MS, Coit DG. Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a positive sentinel lymph node biopsy. Ann Surg Oncol 2007;14(7):2133-40. doi: 10.1245/s10434-007-9399-3
15. Balch CM, Urist MM, Karakousis CP, et al. Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm). Results of a multi-institutional randomized surgical trial. Ann Surg 1993;218(3):262-7; discussion 7-9.
16. Cohn-Cedermark G, Rutqvist LE, Andersson R, et al. Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8-2.0 mm. Cancer 2000;89(7):1495-501.
17. Haigh PI, DiFronzo LA, McCready DR. Optimal excision margins for primary cutaneous melanoma: a systematic review and meta-analysis. Can J Surg 2003;46(6):419-26.
18. Veronesi U, Cascinelli N, Adamus J, et al. Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm. N Engl J Med 1988;318(18):1159-62. doi: 10.1056/NEJM198805053181804
19. Eskiizmir G, Gencoglan G, Temiz P, Hircin Z, Ermertcan A. Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose. Eur Arch Otorhinolaryngol 2011;268(1):117-21. doi: 10.1007/s00405-010-1324-x
20. Moyer JS, Rudy S, Boonstra PS, et al. Efficacy of Staged Excision With Permanent Section Margin Control for Cutaneous Head and Neck Melanoma. JAMA Dermatol 2017;153(3):282-8. doi: 10.1001/jamadermatol.2016.4603
21. Gershenwald JE, Scolyer RA, Hess KR, et al. Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67(6):472-92. doi: 10.3322/caac.21409
22. Pathak I, O'Brien CJ, Petersen-Schaeffer K, et al. Do nodal metastases from cutaneous melanoma of the head and neck follow a clinically predictable pattern? Head Neck 2001;23(9):785-90.
23. Thom JJ, Moore EJ, Price DL, Kasperbauer JL, Starkman SJ, Olsen KD. The Role of Total Parotidectomy for Metastatic Cutaneous Squamous Cell Carcinoma and Malignant Melanoma. JAMA Otolaryngol Head Neck Surg 2014;140(6):548-54. doi: 10.1001/jamaoto.2014.352
24. Agrawal S, Kane JM, 3rd, Guadagnolo BA, Kraybill WG, Ballo MT. The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer 2009;115(24):5836-44. doi: 10.1002/cncr.24627
25. Morton DL, Thompson JF, Cochran AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 2006;355(13):1307-17. doi: 10.1056/NEJMoa060992
26. Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014;370(7):599-609. doi: 10.1056/NEJMoa1310460
27. Sladden M, Zagarella S, Popescu C, Bigby M. No survival benefit for patients with melanoma undergoing sentinel lymph node biopsy: critical appraisal of the Multicenter Selective Lymphadenectomy Trial-I final report. Br J Dermatol 2015;172(3):566-71. doi: 10.1111/bjd.13675
28. de Rosa N, Lyman GH, Silbermins D, et al. Sentinel node biopsy for head and neck melanoma: a systematic review. Otolaryngol Head Neck Surg 2011;145(3):375-82. doi: 10.1177/0194599811408554
29. Miller MW, Vetto JT, Monroe MM, Weerasinghe R, Andersen PE, Gross ND. False-negative sentinel lymph node biopsy in head and neck melanoma. Otolaryngol Head Neck Surg 2011;145(4):606-11. doi: 10.1177/0194599811411878
30. Bilimoria KY, Balch CM, Bentrem DJ, et al. Complete lymph node dissection for sentinel node-positive melanoma: assessment of practice patterns in the United States. Ann Surg Oncol 2008;15(6):1566-76. doi: 10.1245/s10434-008-9885-2
31. Leiter U, Stadler R, Mauch C, et al. Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol 2016;17(6):757-67. doi: 10.1016/S1470-2045(16)00141-8
32. Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med 2017;376(23):2211-22. doi: 10.1056/NEJMoa1613210

There are 32 citations in total.

Details

Primary Language	English
Journal Section	Articles
Authors	Erdoğan Özgür Barış Karakullukçu This is me Görkem Eskiizmir This is me
Publication Date	March 19, 2019
Submission Date	October 21, 2018
Acceptance Date	February 6, 2019
Published in Issue	Year 2019

Cite

APA	Özgür, E., Karakullukçu, B., & Eskiizmir, G. (2019). Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck. ENT Updates, 9(1), 25-33. https://doi.org/10.32448/entupdates.536860
AMA	Özgür E, Karakullukçu B, Eskiizmir G. Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck. ENT Updates. March 2019;9(1):25-33. doi:10.32448/entupdates.536860
Chicago	Özgür, Erdoğan, Barış Karakullukçu, and Görkem Eskiizmir. “Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck”. ENT Updates 9, no. 1 (March 2019): 25-33. https://doi.org/10.32448/entupdates.536860.
EndNote	Özgür E, Karakullukçu B, Eskiizmir G (March 1, 2019) Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck. ENT Updates 9 1 25–33.
IEEE	E. Özgür, B. Karakullukçu, and G. Eskiizmir, “Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck”, ENT Updates, vol. 9, no. 1, pp. 25–33, 2019, doi: 10.32448/entupdates.536860.
ISNAD	Özgür, Erdoğan et al. “Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck”. ENT Updates 9/1 (March 2019), 25-33. https://doi.org/10.32448/entupdates.536860.
JAMA	Özgür E, Karakullukçu B, Eskiizmir G. Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck. ENT Updates. 2019;9:25–33.
MLA	Özgür, Erdoğan et al. “Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck”. ENT Updates, vol. 9, no. 1, 2019, pp. 25-33, doi:10.32448/entupdates.536860.
Vancouver	Özgür E, Karakullukçu B, Eskiizmir G. Current Treatment Strategies in Cutaneous Malignant Melanoma of the Head and Neck. ENT Updates. 2019;9(1):25-33.

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