Schwannoma of hypopharynx: A Rare Entity

Abstract

We report the case of a 55-year old Caucasian female who presented with dysphagia after being operated for a brain glioblastoma. Fiberoptic endoscopy and magnetic resonance imaging showed a submucosal tumefaction of the posterior hypopharyngeal wall. Direct laryngoscopy and biopsy did not reveal a definitive diagnosis. The lesion was completely removed using a transoral C02 laser, and histopathological examination of the lesion showed a diagnosis of hypopharyngeal schwannoma. The patient recovered uneventfully and has remained clinically and radiologically disease-free for 6 months. Surgical excision and S100 protein immunohistochemistry remain the gold standards for treatment and diagnosis of hypopharyngeal schwannomas.

Keywords

• Hypopharynx,schwannoma,S100 proteins,surgery

References

1. 1. Hanemann CO, Evans DG. News on the genetics, epidemiology, medical care and translational research of Schwannomas. J Neurol 2006;253:1533-41.
2. 2. Ahmed AO, Umar AB, Aluko AA, Yaro MA. Hypopharyngeal schwannoma:A rare case presentation and review of literatures. Niger J Basic Clin Sci 2013;10:29-32.
3. 3. Isobe K, Shimizu T, Akahane T, Kato H. Imaging of Ancient Schwannoma. AJR Am J Roentgenol. 2004;183:331-6.
4. 4. Dey P, Mallik MK, Gupta SK, Vasishta RK. Role of fine needle aspiration cytology in the diagnosis of soft tissue tumours and tumour-like lesions. Cytopathology 2004;15:32-7.
5. 5. Ansarin M, Tagliabue M, Chu F, Zorzi S, Proh M, Preda L. Transoral Robotic Surgery in Retrostyloid Parapharyngeal Space Schwannomas. Case Rep Otolaryngol 2014;2014:296025.
6. 6. Gallego O. Nonsurgical treatment of recurrent glioblastoma. Curr Oncol 2015;22:273-81.
7. 7. Berkowitz O, Iyer AK, Kano H, Talbott EO, Lunsford LD. Epidemiology and Environmental Risk Factors Associated with Vestibular Schwannoma. World Neurosurg 2015;84:1674-80.
8. 8. Cutfield SW, Wickremesekera AC, Mantamadiotis T, et al. Tumour stem cells in schwannoma: A review. J Clin Neurosci 2019;62:21-6.

9. 9. Hamaguchi N, Otsu K, Ishinaga H, Takeuchi K. A Case of Hypopharyngeal Schwannoma. Nihon Kikan Shokudoka Gakkai Kaiho 2015;66:25-30.
10. 10. Lee WJ, Isaacson JE. Postoperative imaging and follow-up of vestibular schwannomas. Otol Neurotol 2005;26:102-4.