Research Article
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Year 2020, Volume: 10 Issue: 3, 439 - 443, 30.12.2020

Emre Ocak , Muhammed Sefa Uyar , Deniz Kocaoz Emre Mirici Aydın Acar

https://doi.org/10.32448/entupdates.814569

Abstract

References

  • 1. Adour KK, Byl FM, Hilsinger Jr RL, et al. The true nature of Bell's palsy: analysis af 1,000 consecutive patients. The Laryngoscope 1978; 88: 787-801.
  • 2. Baugh RF, Basura GJ, Ishii LE, et al. Clinical practice guideline: Bell’s palsy executive summary. Otolaryngology–Head and Neck Surgery 2013; 149: 656-663.
  • 3. Peitersen E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Oto-Laryngologica 2002; 122:4-30.
  • 4. Morgan J. Global trends in candidemia: review of reports from 1995–2005. Current Infectious Disease Reports 2005; 7: 429-439.
  • 5. Takemoto N, Horii A, Sakata Y, Inohara H. Prognostic factors of peripheral facial palsy: multivariate analysis followed by receiver operating characteristic and Kaplan-Meier analyses. Otology & neurotology 2011; 32: 1031-1036.
  • 6. Kanerva M, Jonsson L, Berg T, et al. Sunnybrook and House-Brackmann systems in 5397 facial gradings. Otolaryngology--Head and Neck Surgery 2011; 144: 570-574.
  • 7. Grosheva M, Wittekindt C, Guntinas‐Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. The laryngoscope 2008; 118: 394-397.
  • 8. Holick MF. New England Journal of Medicine. NEJM 2007; 357: 266-281.
  • 9. Makariou S, Liberopoulos EN, Elisaf M, Challa A. Novel roles of vitamin D in disease: what is new in 2011?. European Journal of Internal Medicine 2011; 22: 355-362.
  • 10. Zipitis C S, Akobeng A K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Archives of disease in childhood 2008; 93: 512-517.
  • 11. Celikbilek A, Gocmen AY, Tanik N, et al. Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey. Acta Neurologica Belgica 2015; 115:47-52.
  • 12. Bajaj S, Singh RP, Dwivedi NC, Singh K, Gupta A, Mathur M. Vitamin D levels and microvascular complications in type 2 diabetes. Indian Journal of Endocrinology and Metabolism 2014; 18: 537.
  • 13. Engström M, Berg T, Stjernquist-Desatnik A, et. al. Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet Neurology 2008; 7: 993-1000.
  • 14. WHO Scientific Group on the Prevention and Management of Osteoporosis (‎2000 : Geneva, Switzerland)‎. (‎2003)‎. Prevention and management of osteoporosis : report of a WHO scientific group. World Health Organization.
  • 15. Lee HY, Byun JY, Park MS, Yeo SG. Effect of aging on the prognosis of Bell’s palsy. Otology & Neurotology 2013; 34:766-770.
  • 16. Baba S, Kondo K, Kanaya K, Ushio M, Tojima H, Yamasoba T. Bell’s palsy in children: relationship between electroneurography findings and prognosis in comparison with adults. Otology & Neurotology 2011, 32: 1554-1558.
  • 17. Riga M, Kefalidis G, Danielides V. The role of diabetes mellitus in the clinical presentation and prognosis of Bell palsy. The Journal of the American Board of Family Medicine 2012; 25: 819-826.
  • 18. Özler GS. Increased neutrophil-lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss. Journal of Craniofacial Surgery 2014; 25: e260-e263.
  • 19. Bucak A, Ulu S, Oruc S. Neutrophil‐to‐lymphocyte ratio as a novel‐potential marker for predicting prognosis of Bell palsy. The Laryngoscope 2014; 124: 1678-1681.
  • 20. Kilicaslan S, Uluyol S, Gur MH, Arslan IB, Yagiz O. Diagnostic and prognostic value of procalcitonin levels in patients with Bell’s palsy. European Archives of Oto-Rhino-Laryngology 2016; 273: 1615-1618.
  • 21. Mancini P, De Seta D, Prosperini L. Prognostic factors of Bell's palsy: multivariate analysis of electrophysiological findings. The Laryngoscope 2014; 124: 2598-2605.
  • 22. Chung JH, Lee SK, Kim SH, Yeo SG, Park MS, Byun JY. Neurotological parameters and prognosis of Bell's palsy patients. Audiology and Neurotology 2015; 20: 117-121.
  • 23. Li S, Guo RJ, Liang XN, et al. High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. Experimental and Therapeutic Medicine 2016;11:77-82.
  • 24. Glendenning P. Abnormal laboratory results: Measuring vitamin D. Australian Prescriber 2015; 38: 12.
  • 25. de Abreu DF, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009; 34: S265-S277.
  • 26. Chabas JF, Alluin O, Rao G, et al. Vitamin D2 potentiates axon regeneration. Journal of Neurotrauma 2008;25: 1247-1256.
  • 27. Chabas JF, Stephan D, Marqueste T, et al. Cholecalciferol (vitamin D 3) improves myelination and recovery after nerve injury. Plos one 2013; 8: e65034.
  • 28. Cornet A, Baudet C, Neveu I, Baron‐Van Evercooren A, Brachet P, Naveilhan P. 1, 25‐dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. Journal of Neuroscience Research 1998; 53: 742-746.
  • 29. Marchesi C, Milani M, Morbin M, et al. Four novel cases of periaxin-related neuropathy and review of the literature. Neurology 2010;75: 1830-1838.
  • 30. Terada N, Baracskay K, Kinter M, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to β1 integrin, CD81, and Tspan‐2. Glia 2002; 40: 350-359.
  • 31. Montava M, Garcia S, Mancini J. Vitamin D3 potentiates myelination and recovery after facial nerve injury. European Archives of Oto-Rhino-Laryngology 2015; 272:2815-2823.

Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy

Year 2020, Volume: 10 Issue: 3, 439 - 443, 30.12.2020

Emre Ocak , Muhammed Sefa Uyar , Deniz Kocaoz Emre Mirici Aydın Acar

https://doi.org/10.32448/entupdates.814569

Abstract

Objective: To investigate the role of vitamin D on the etiology and the prognosis of Bell’s Palsy (BP).
Methods: A prospective controlled clinical study was conducted on patients diagnosed as BP and healthy volunteers as control group. Vitamin D levels were measured in all subjects. In a homogenous group, effects of vitamin D on the etiology and prognosis were evaluated according to House-Brackmann (HB) grades of participants.
Results: Vitamin D levels were similar in the BP and control groups. In BP group, patients with advanced HB grades had lower vitamin D levels. Moreover poorer outcomes (p=0.01) were achieved in patients who had <10ng/ml vitamin D, regardless the initial HB grade.
Conclusion: Our results demonstrated a possible role of vitamin D levels on the prognosis of BP. Lower vitamin
D levels may have a negative effect on recovery particularly in patients with advanced grades.

Keywords

Vitamin D Facial paralysis Bell Palsy

References

  • 1. Adour KK, Byl FM, Hilsinger Jr RL, et al. The true nature of Bell's palsy: analysis af 1,000 consecutive patients. The Laryngoscope 1978; 88: 787-801.
  • 2. Baugh RF, Basura GJ, Ishii LE, et al. Clinical practice guideline: Bell’s palsy executive summary. Otolaryngology–Head and Neck Surgery 2013; 149: 656-663.
  • 3. Peitersen E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Oto-Laryngologica 2002; 122:4-30.
  • 4. Morgan J. Global trends in candidemia: review of reports from 1995–2005. Current Infectious Disease Reports 2005; 7: 429-439.
  • 5. Takemoto N, Horii A, Sakata Y, Inohara H. Prognostic factors of peripheral facial palsy: multivariate analysis followed by receiver operating characteristic and Kaplan-Meier analyses. Otology & neurotology 2011; 32: 1031-1036.
  • 6. Kanerva M, Jonsson L, Berg T, et al. Sunnybrook and House-Brackmann systems in 5397 facial gradings. Otolaryngology--Head and Neck Surgery 2011; 144: 570-574.
  • 7. Grosheva M, Wittekindt C, Guntinas‐Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. The laryngoscope 2008; 118: 394-397.
  • 8. Holick MF. New England Journal of Medicine. NEJM 2007; 357: 266-281.
  • 9. Makariou S, Liberopoulos EN, Elisaf M, Challa A. Novel roles of vitamin D in disease: what is new in 2011?. European Journal of Internal Medicine 2011; 22: 355-362.
  • 10. Zipitis C S, Akobeng A K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Archives of disease in childhood 2008; 93: 512-517.
  • 11. Celikbilek A, Gocmen AY, Tanik N, et al. Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey. Acta Neurologica Belgica 2015; 115:47-52.
  • 12. Bajaj S, Singh RP, Dwivedi NC, Singh K, Gupta A, Mathur M. Vitamin D levels and microvascular complications in type 2 diabetes. Indian Journal of Endocrinology and Metabolism 2014; 18: 537.
  • 13. Engström M, Berg T, Stjernquist-Desatnik A, et. al. Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet Neurology 2008; 7: 993-1000.
  • 14. WHO Scientific Group on the Prevention and Management of Osteoporosis (‎2000 : Geneva, Switzerland)‎. (‎2003)‎. Prevention and management of osteoporosis : report of a WHO scientific group. World Health Organization.
  • 15. Lee HY, Byun JY, Park MS, Yeo SG. Effect of aging on the prognosis of Bell’s palsy. Otology & Neurotology 2013; 34:766-770.
  • 16. Baba S, Kondo K, Kanaya K, Ushio M, Tojima H, Yamasoba T. Bell’s palsy in children: relationship between electroneurography findings and prognosis in comparison with adults. Otology & Neurotology 2011, 32: 1554-1558.
  • 17. Riga M, Kefalidis G, Danielides V. The role of diabetes mellitus in the clinical presentation and prognosis of Bell palsy. The Journal of the American Board of Family Medicine 2012; 25: 819-826.
  • 18. Özler GS. Increased neutrophil-lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss. Journal of Craniofacial Surgery 2014; 25: e260-e263.
  • 19. Bucak A, Ulu S, Oruc S. Neutrophil‐to‐lymphocyte ratio as a novel‐potential marker for predicting prognosis of Bell palsy. The Laryngoscope 2014; 124: 1678-1681.
  • 20. Kilicaslan S, Uluyol S, Gur MH, Arslan IB, Yagiz O. Diagnostic and prognostic value of procalcitonin levels in patients with Bell’s palsy. European Archives of Oto-Rhino-Laryngology 2016; 273: 1615-1618.
  • 21. Mancini P, De Seta D, Prosperini L. Prognostic factors of Bell's palsy: multivariate analysis of electrophysiological findings. The Laryngoscope 2014; 124: 2598-2605.
  • 22. Chung JH, Lee SK, Kim SH, Yeo SG, Park MS, Byun JY. Neurotological parameters and prognosis of Bell's palsy patients. Audiology and Neurotology 2015; 20: 117-121.
  • 23. Li S, Guo RJ, Liang XN, et al. High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. Experimental and Therapeutic Medicine 2016;11:77-82.
  • 24. Glendenning P. Abnormal laboratory results: Measuring vitamin D. Australian Prescriber 2015; 38: 12.
  • 25. de Abreu DF, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009; 34: S265-S277.
  • 26. Chabas JF, Alluin O, Rao G, et al. Vitamin D2 potentiates axon regeneration. Journal of Neurotrauma 2008;25: 1247-1256.
  • 27. Chabas JF, Stephan D, Marqueste T, et al. Cholecalciferol (vitamin D 3) improves myelination and recovery after nerve injury. Plos one 2013; 8: e65034.
  • 28. Cornet A, Baudet C, Neveu I, Baron‐Van Evercooren A, Brachet P, Naveilhan P. 1, 25‐dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. Journal of Neuroscience Research 1998; 53: 742-746.
  • 29. Marchesi C, Milani M, Morbin M, et al. Four novel cases of periaxin-related neuropathy and review of the literature. Neurology 2010;75: 1830-1838.
  • 30. Terada N, Baracskay K, Kinter M, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to β1 integrin, CD81, and Tspan‐2. Glia 2002; 40: 350-359.
  • 31. Montava M, Garcia S, Mancini J. Vitamin D3 potentiates myelination and recovery after facial nerve injury. European Archives of Oto-Rhino-Laryngology 2015; 272:2815-2823.
There are 31 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Research Article
Authors

Emre Ocak 0000-0003-0652-2777

Muhammed Sefa Uyar 0000-0002-1149-6238

Deniz Kocaoz This is me 0000-0002-6154-3637

Emre Mirici This is me 0000-0002-2703-1312

Aydın Acar 0000-0002-1035-5601

Submission Date October 22, 2020
Acceptance Date December 17, 2020
Publication Date December 30, 2020
Published in Issue Year 2020 Volume: 10 Issue: 3

Cite

APA Ocak, E., Uyar, M. S., Kocaoz, D., … Mirici, E. (2020). Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates, 10(3), 439-443. https://doi.org/10.32448/entupdates.814569
AMA Ocak E, Uyar MS, Kocaoz D, Mirici E, Acar A. Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates. December 2020;10(3):439-443. doi:10.32448/entupdates.814569
Chicago Ocak, Emre, Muhammed Sefa Uyar, Deniz Kocaoz, Emre Mirici, and Aydın Acar. “Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy”. ENT Updates 10, no. 3 (December 2020): 439-43. https://doi.org/10.32448/entupdates.814569.
EndNote Ocak E, Uyar MS, Kocaoz D, Mirici E, Acar A (December 1, 2020) Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates 10 3 439–443.
IEEE E. Ocak, M. S. Uyar, D. Kocaoz, E. Mirici, and A. Acar, “Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy”, ENT Updates, vol. 10, no. 3, pp. 439–443, 2020, doi: 10.32448/entupdates.814569.
ISNAD Ocak, Emre et al. “Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy”. ENT Updates 10/3 (December2020), 439-443. https://doi.org/10.32448/entupdates.814569.
JAMA Ocak E, Uyar MS, Kocaoz D, Mirici E, Acar A. Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates. 2020;10:439–443.
MLA Ocak, Emre et al. “Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy”. ENT Updates, vol. 10, no. 3, 2020, pp. 439-43, doi:10.32448/entupdates.814569.
Vancouver Ocak E, Uyar MS, Kocaoz D, Mirici E, Acar A. Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates. 2020;10(3):439-43.