25(OH)D3 levels in children with allergic rhinoconjunctivitis

Year 2015, Volume: 5 Issue: 3, 97 - 102, 14.01.2016

Ahmet Türkeli Sevilay Aynacı

Abstract

Objective: In this prospective study, we investigated the serum vitamin D levels [serum 25(OH)D3 levels] in children with allergic
rhinoconjunctivitis (ARC).
Methods: Sixty-one children with allergic rhinoconjunctivitis (study
group) and 61 healthy children (control group) were included into the
study. The children in the study group had an allergy against at least
one active agent at skin-prick test; a total of 5 Symptoms Score
(T5SS) was obtained for vitamin D [25(OH)D3] levels. Total
eosinophil counts and total IgE measurement were performed.
Results: In ARC group, median of T5SS scores was 1.00 for each of the
rhinorrhea, sneezing, nasal congestion and nasal pruritis items. In ARC
group, total eosinophil count and total IgE values were also higher than
the control group. In ARC group, familial atopy was higher, and sunlight exposure was lower than the control group. Serum 25(OH)D3 levels of the ARC group (median: 15.80 ng/ml) were significantly lower
than the control group (18.40 ng/ml). Considering the vitamin D levels
being as sufficient/or deficient; it was deficient in 80.3% of the children
in the study group and in 57.4% of the children in the control group.
In the study group, sunlight exposure was insufficient; and familial
atopy was present. In children with sufficient sunlight exposure, serum
25(OH)D3 levels were detected as higher. In children with familial
atopy, total IgE and total eosinophil counts also increased.
Conclusion: We concluded that vitamin D levels were lower in children
with ARC. We recommend children to expose sunlight sufficiently to
increase vitamin D levels; and therefore reduce the risk of allergic rhinoconjunctivitis. 

Keywords

25(OH)D3, allergic rhinoconjunctivitis, total IgE, total eosinophil count, familial atopy

Alerjik rinokonjonktivitli çocuklarda 25(OH)D3 düzeyleri

Abstract

Amaç: Bu prospektif çal›flmada alerjik rinokonjonktivitli (ARK) çocuklarda serum D vitamini [serum 25(OH)D3 düzeyleri] düzeylerini
araflt›rd›k.
Yöntem: Alerjik rinokonjonktivitli 61 çocuk (çal›flma grubu) ve 61 sa¤-
l›kl› çocuk (kontrol grubu) çal›flmaya dahil edildi. Çal›flma grubu, deri
i¤neleme testinde en az›ndan bir aktif etkene karfl› alerjikti. D vitamini
[25(OH)D3] düzeyleri için Toplam 5 Semptom Skoru (T5SS) elde
edildi, total eozinofil say›mlar› ve total IgE ölçümleri yap›ld›.
Bulgular: Alerjik rinokonjonktivit grubunda rinore, aks›rma, nazal
konjesyon ve nazal kafl›nt› semptomlar›n›n her biri için ortanca T5SS
skoru 1.00 idi. ARK grubunda total eozinofil say›s› ve total IgE de¤erleri de kontrol grubuna göre daha yüksekti. Kontrol grubuna göre
ARK grubunda ailevi atopi daha yüksek ve günefle maruziyet daha düflüktü. ARK grubunda serum 25(OH)D3 düzeyleri (ortanca: 15.80
ng/ml) kontrol grubuna göre anlaml› derece daha düflüktü (18.40
ng/ml). D vitamini düzeylerinin yeterli veya yetersiz olma durumu ele
al›nd›¤›nda kontrol grubundaki çocuklar›n %57.4’ü ve çal›flma grubundaki çocuklar›n ise %80.3’ünde D vitamini eksikli¤i mevcuttu.
Çal›flma grubunda günefl ›fl›¤›na maruziyet yeterli de¤ildi ve ailevi
atopi mevcuttu. Yeterince günefl ›fl›¤› alan çocuklarda serum
25(OH)D3 düzeylerinin daha yüksek oldu¤u saptand›. Ailevi atopisi
olan çocuklarda total IgE ve total eozinofil say›lar› da artm›flt›.
Sonuç: Alerjik rinokonjonktivitli çocuklarda D vitamini düzeylerinin
daha düflük oldu¤u sonucuna vard›k. D vitamini düzeylerini yükseltmek ve böylece ARK riskini azaltmak çin çocuklar›n yeterince günefl
›fl›¤› almas›n› öneriyoruz. 

Keywords

25(OH)D3, alerjik rinokonjonktivit, total IgE, total eozinofil sayısı, ailevi atopi

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• Please cite this article as: Türkeli A, Aynacı S. 25(OH)D3 levels in children with allergic rhinoconjunctivitis. ENT Updates 2015;5(3):97–102.