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Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı

Year 2016, Volume: 6 Issue: 2, 91 - 94, 31.08.2016

Abstract

Objective: To evaluate the clinical and pathologic parameters associated with level IIb metastasis in transglottic laryngeal carcinoma.
Methods: A total of 238 laryngeal squamous cell carcinoma patients admitted to our tertiary center and surgically treated between January 2006 and January 2014. Of these 238 patients, 134 patients with transglottic laryngeal SCC were enrolled in the study. The type of neck dissection, the location of histopathologically proven metastatic lymph nodes, clinical N and T stages were reviewed. Palpable lymph nodes were accepted clinically cN(+) and the opposite as cN(-).
Results: Of the 134 patients, 116 were diagnosed as cN(-), and 18 were as cN(+). Level IIb metastasis was diagnosed in 12 patients in the cN(+) group, and in two patients in the cN(-) group. Histopathological level IIb metastasis was shown in 14 of 134 patients, representing 16 of 268 neck dissection specimens. Level IIb metastasis was shown in the ipsilateral specimens in 12 patients and contralateral specimens in two patients. Forty-one of 134 patients presented cartilage invasion, and nine of them were diagnosed with level IIb metastasis.

Conclusion: Thyroid cartilage invasion, the presence of level IIa invasion and advanced stage disease are the risk factors for level IIb metastasis. Therefore, level IIb should not be neglected during neck dissection in transglotticlaryngeal carcinoma.

References

  • 1. Kirchner JA. Staging as seen in serial sections. Laryngoscope 1975;85:1816–21.
  • 2. Dijkstra PU, van Wilgen PC, Buijs RP, et al. Incidence of shoulder pain after neck dissection: a clinical explorative study for risk factors. Head Neck 2001;23:947–53.
  • 3. Leipzig B, Suen JY, English JL, Barnes J, Hooper M. Functional evaluation of the spinal accessory nerve after neck dissection. Am J Surg 1983;146:526–30.
  • 4. Pinsolle V, Michelet V, Majoufre C, Caix P, Siberchicot F, Pinsolle J. Spinal accessory nerve and lymphatic neck dissection. [Article in French] Rev Stomatol Chir Maxilofac 1997;98:138–42.
  • 5. Suen JY, Goepfert H. Standardization of neck dissection nomenclature. Head Neck Surg 1987;10:75–7.
  • 6. Calearo CV, Teatini G. Functional neck dissection. Anatomical grounds, surgical technique, clinical observations. Ann Otol Rhinol Laryngol 1983;92:215–22.
  • 7. Talmi YP, Hoffman HT, Horowitz Z, et al. Patterns of metastases to the upper jugular lymph nodes (the “submuscular recess”). Head Neck 1998;20:682–6.
  • 8. Koybasioglu A, Uslu S, Yilmaz M, Inal E, Ileri F, Asal K. Lymphatic metastasis to the supraretrospinal recess in laryngeal squamous cell carcinoma. Ann Otol Rhinol Laryngol 2002;111: 96–9.
  • 9. Santoro R, Franchi A, Gallo O, Burali G, de’ Campora E. Nodal metastases at level IIb during neck dissection for head and neck cancer: clinical and pathologic evaluation. Head Neck 2008;30: 1483–7.
  • 10. Chone CT, Crespo AN, Rezende AS, Carvalho DS, Altemani A. Neck lymph node metastases to the posterior triangle apex: evaluation of clinical and histopathological risk factors. Head Neck 2000;22:564–71.
  • 11. Coskun HH, Erisen L, Basut O. Selective neck dissection for clinically N0 neck in laryngeal cancer: is dissection of level IIb necessary? Otolaryngol Head Neck Surg 2004;131:655–9.
  • 12. Corlette TH, Cole IE, Albsoul N, Ayyash M. Neck dissection of level IIb: is it really necessary? Laryngoscope 2005;115:1624–6.
  • 13. Silverman DA, El-Hajj M, Strome S, Esclamado RM. Prevalence of nodal metastases in the submuscular recess (level IIb) during selective neck dissection. Arch Otolaryngol Head Neck Surg 2003;129:724–8.
  • 14. Elsheikh MN, Mahfouz ME, Salim EI, Elsheikh EA. Molecular assessment of neck dissections supports preserving level IIB lymph nodes in selective neck dissection for laryngeal squamous cell carcinoma with a clinically negative neck. ORL J Otorhinolaryngol Relat Spec 2006;68:177–84.
  • 15. Lim YC, Lee JS, Koo BS, Choi EC. Level IIb lymph node metastasis in laryngeal squamous cell carcinoma. Laryngoscope 2006;116:268–72.
  • 16. Villaret AB, Piazza C, Peretti G, Calabrese L, Ansarin M, Chiesa F et al. Multicentric prospective study on the prevalence of sublevel IIb metastases in head and neck cancer. Arch Otolaryngol Head Neck Surg 2007;133:897–903.
  • 17. Sezen OS, Kubilay U, Haytoglu S, Unver S. Frequency of metastases at the area of the supraretrospinal (level IIb) lymph node in laryngeal cancer. Head Neck 2007;29:1111–4.
  • 18. Dündar R, Aslan H, Özbay C, et al. The necessity of dissection of level IIb in laryngeal squamous cell carcinoma: a clinical study. Otolaryngol Head Neck Surg 2012;146:390–4.
  • 19. Wiegand S, Esters J, Müller HH, et al. Relevance of level I and IIB neck dissection in laryngeal cancer. J Laryngol Otol 2012; 126:795–9.
Year 2016, Volume: 6 Issue: 2, 91 - 94, 31.08.2016

Abstract

References

  • 1. Kirchner JA. Staging as seen in serial sections. Laryngoscope 1975;85:1816–21.
  • 2. Dijkstra PU, van Wilgen PC, Buijs RP, et al. Incidence of shoulder pain after neck dissection: a clinical explorative study for risk factors. Head Neck 2001;23:947–53.
  • 3. Leipzig B, Suen JY, English JL, Barnes J, Hooper M. Functional evaluation of the spinal accessory nerve after neck dissection. Am J Surg 1983;146:526–30.
  • 4. Pinsolle V, Michelet V, Majoufre C, Caix P, Siberchicot F, Pinsolle J. Spinal accessory nerve and lymphatic neck dissection. [Article in French] Rev Stomatol Chir Maxilofac 1997;98:138–42.
  • 5. Suen JY, Goepfert H. Standardization of neck dissection nomenclature. Head Neck Surg 1987;10:75–7.
  • 6. Calearo CV, Teatini G. Functional neck dissection. Anatomical grounds, surgical technique, clinical observations. Ann Otol Rhinol Laryngol 1983;92:215–22.
  • 7. Talmi YP, Hoffman HT, Horowitz Z, et al. Patterns of metastases to the upper jugular lymph nodes (the “submuscular recess”). Head Neck 1998;20:682–6.
  • 8. Koybasioglu A, Uslu S, Yilmaz M, Inal E, Ileri F, Asal K. Lymphatic metastasis to the supraretrospinal recess in laryngeal squamous cell carcinoma. Ann Otol Rhinol Laryngol 2002;111: 96–9.
  • 9. Santoro R, Franchi A, Gallo O, Burali G, de’ Campora E. Nodal metastases at level IIb during neck dissection for head and neck cancer: clinical and pathologic evaluation. Head Neck 2008;30: 1483–7.
  • 10. Chone CT, Crespo AN, Rezende AS, Carvalho DS, Altemani A. Neck lymph node metastases to the posterior triangle apex: evaluation of clinical and histopathological risk factors. Head Neck 2000;22:564–71.
  • 11. Coskun HH, Erisen L, Basut O. Selective neck dissection for clinically N0 neck in laryngeal cancer: is dissection of level IIb necessary? Otolaryngol Head Neck Surg 2004;131:655–9.
  • 12. Corlette TH, Cole IE, Albsoul N, Ayyash M. Neck dissection of level IIb: is it really necessary? Laryngoscope 2005;115:1624–6.
  • 13. Silverman DA, El-Hajj M, Strome S, Esclamado RM. Prevalence of nodal metastases in the submuscular recess (level IIb) during selective neck dissection. Arch Otolaryngol Head Neck Surg 2003;129:724–8.
  • 14. Elsheikh MN, Mahfouz ME, Salim EI, Elsheikh EA. Molecular assessment of neck dissections supports preserving level IIB lymph nodes in selective neck dissection for laryngeal squamous cell carcinoma with a clinically negative neck. ORL J Otorhinolaryngol Relat Spec 2006;68:177–84.
  • 15. Lim YC, Lee JS, Koo BS, Choi EC. Level IIb lymph node metastasis in laryngeal squamous cell carcinoma. Laryngoscope 2006;116:268–72.
  • 16. Villaret AB, Piazza C, Peretti G, Calabrese L, Ansarin M, Chiesa F et al. Multicentric prospective study on the prevalence of sublevel IIb metastases in head and neck cancer. Arch Otolaryngol Head Neck Surg 2007;133:897–903.
  • 17. Sezen OS, Kubilay U, Haytoglu S, Unver S. Frequency of metastases at the area of the supraretrospinal (level IIb) lymph node in laryngeal cancer. Head Neck 2007;29:1111–4.
  • 18. Dündar R, Aslan H, Özbay C, et al. The necessity of dissection of level IIb in laryngeal squamous cell carcinoma: a clinical study. Otolaryngol Head Neck Surg 2012;146:390–4.
  • 19. Wiegand S, Esters J, Müller HH, et al. Relevance of level I and IIB neck dissection in laryngeal cancer. J Laryngol Otol 2012; 126:795–9.
There are 19 citations in total.

Details

Subjects Health Care Administration
Journal Section Articles
Authors

Yılmaz Özkul This is me

Rıza Dündar This is me

Abdulkadir İmre This is me

Seçil Arslanoğlu This is me

Elif Dinçer This is me

Düzgün Ateş This is me

Ercan Pınar This is me

Kazım Önal This is me

Publication Date August 31, 2016
Submission Date July 24, 2017
Published in Issue Year 2016 Volume: 6 Issue: 2

Cite

APA Özkul, Y., Dündar, R., İmre, A., Arslanoğlu, S., et al. (2016). Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı. ENT Updates, 6(2), 91-94.
AMA Özkul Y, Dündar R, İmre A, Arslanoğlu S, Dinçer E, Ateş D, Pınar E, Önal K. Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı. ENT Updates. August 2016;6(2):91-94.
Chicago Özkul, Yılmaz, Rıza Dündar, Abdulkadir İmre, Seçil Arslanoğlu, Elif Dinçer, Düzgün Ateş, Ercan Pınar, and Kazım Önal. “Transglottik Larinks skuamöz hücreli Karsinomlarda Level IIb Lenf Nodu Metastazı”. ENT Updates 6, no. 2 (August 2016): 91-94.
EndNote Özkul Y, Dündar R, İmre A, Arslanoğlu S, Dinçer E, Ateş D, Pınar E, Önal K (August 1, 2016) Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı. ENT Updates 6 2 91–94.
IEEE Y. Özkul, R. Dündar, A. İmre, S. Arslanoğlu, E. Dinçer, D. Ateş, E. Pınar, and K. Önal, “Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı”, ENT Updates, vol. 6, no. 2, pp. 91–94, 2016.
ISNAD Özkul, Yılmaz et al. “Transglottik Larinks skuamöz hücreli Karsinomlarda Level IIb Lenf Nodu Metastazı”. ENT Updates 6/2 (August 2016), 91-94.
JAMA Özkul Y, Dündar R, İmre A, Arslanoğlu S, Dinçer E, Ateş D, Pınar E, Önal K. Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı. ENT Updates. 2016;6:91–94.
MLA Özkul, Yılmaz et al. “Transglottik Larinks skuamöz hücreli Karsinomlarda Level IIb Lenf Nodu Metastazı”. ENT Updates, vol. 6, no. 2, 2016, pp. 91-94.
Vancouver Özkul Y, Dündar R, İmre A, Arslanoğlu S, Dinçer E, Ateş D, Pınar E, Önal K. Transglottik larinks skuamöz hücreli karsinomlarda level IIb lenf nodu metastazı. ENT Updates. 2016;6(2):91-4.