Sitokin geni polimorfizmleri ve Türk pediyatrik koklear implant hastalarındaki ekspresyonu

Year 2016, Volume: 6 Issue: 1, 1 - 4, 30.04.2016

Elif Baysal Sibel Oğuzkan Balcı Fatih Çelenk Merve Kahraman Murat Deniz Orhan Tunç Cengiz Durucu Semih Mumbuç Muzaffer Kanlıkama Sacide Pehlivan

Abstract

Objective:

We assessed the association between
the polymorphisms and expressions of three cytokine genes and clinical
parameters in children who underwent cochlear implantation due to profound congenital
sensorineural hearing loss.

 

Methods:

We analyzed the IL-6/-174, IFN-γ/+874
and TNF-α/-308 genes in 64 cases with congenital sensorineural hearing loss and
in 70 healthy controls. Cytokine genotyping/expression was performed using the PCR-SSP method.

Results:

No significant differences were
detected between the patient group and the healthy controls with respect to the
distributions and numbers of genotypes and alleles of TNF-or IL-6. However, the TT genotype, associated with high
expression of IFN-γ, and the Tallele frequency were significantly more frequent
in the patient group versus the controls (p=0.016 and 0.023, respectively).

Conclusion:

Our results suggest that high
expression of the IFN-γ gene may be associated with susceptibility to the
disease. Consequently, IFN-γ may be a useful marker of the etiopathogenesis.

Keywords

Congenital sensorineural hearing loss, cytokine gene, variation

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