Inflammatory cell types in Reinke's edema

Year 2017, Volume: 7 Issue: 3, 154 - 156, 28.11.2017

H. Bengü Çobanoğlu , Selçuk Arslan Ümit Çobanoğlu Mehmet İmamoğlu

Abstract

Objective: To evaluate the histopathological
findings in Reinke's edema and correlate them with otorhinolaryngologic
symptoms other than dysphonia.




Methods:
Patients diagnosed with Reinke's edema as the source of dysphonia from
January to December 2016 were included in this retrospective study. The
histopathological findings in Reinke's edema and the correlation with
otorhinolaryngologic symptoms other than dysphonia were evaluated.




Results: A
total of 13 patients (3 females, 10 males) with Reinke's edema all of
whom were smokers underwent surgery. In all of the specimens, the main
histopathological finding was edema in the lamina propria of the vocal
folds. The dominant inflammatory cell type in the stroma was determined
by evaluating the whole microscopic subepithelial zone. The cell types
included plasma cells, lymphocytes, monocytes, and neutrophils.




Conclusion: In
Reinke's edema the main pathologic finding is the collection of
edematous fluid in Reinke's space. As our study was limited by the small
number of cases, we could not find any statistically significant
correlation between the inflammatory cell types and clinical
characteristics of Reinke's edema.

Keywords

Inflammation , Reinke's edema , surgery

References

• Pitman MJ, Lebowitz-Cooper A, Iacob C, Tan M. Effect of the 532nm pulsed KTP laser in the treatment of Reinke’s edema. Laryngoscope 2012;122:2786–92. 2. Marcotullio D, Magliulo G, Pezone T. Reinke’s edema and risk factors: clinical and histopathologic aspects. Am J Otolaryngol 2002;23:81–4. 3. Dursun G, Ozgursoy OB, Kemal O, Coruh I. One-year follow-up results of combined use of CO2 laser and cold instrumentation for Reinke’s edema surgery in professional voice users. Eur Arch Otorhinolaryngol 2007;264:1027–32. 4. Sataloff RT, Hawkshaw M, Rosen DC, Spiegel JR. Reinke’s edema. Ear Nose Throat J 1997;76:70. 5. Garrett CG, Ossoff RH. Phonomicrosurgery II: surgical tech- niques. Otolaryngol Clin North Am 2000;33:1063–70. 6. Zeitels SM, Hillman RE, Bunting GW, Vaughn T. Reinke’s edema: phonatory mechanisms and management strategies. Ann Otol Rhinol Laryngol 1997;106:533–43. 7. Yonekawa H. A clinical study of Reinke’s edema. Auris Nasus Larynx 1988;15:57–78. PMID: 3421866 8. Tan M, Bryson PC, Pitts C, Woo P, Benninger MS. Clinical grad- ing of Reinke’s edema. Laryngoscope 2017;127:2310–3. 9. Hellquist H, Lundgren J, Olofsson J. Hyperplasia, keratosis, dys- plasia and carcinoma in situ of the vocal cords – a follow-up study. Clin Otolaryngol Allied Sci 1982;7:11–27. 10. Nawka T, Hosemann W. Surgical procedures for voice restoration. GMS Curr Top Otorhinolaryngol Head Neck Surg 2005;4:Doc14. 11. Tillmann B, Rudert H, Schünke M, Werner JA. Morphological studies on the pathogenesis of Reinke’s edema. Eur Arch Otorhi- nolaryngol 1995;252:469–74.