Neutrophil to lymphocyte and platelet to lymphocyte ratios as an indicator of inflammation in patients with recurrent aphthous stomatitis

Year 2018, Volume: 8 Issue: 1, 41 - 44, 05.04.2018

Mustafa Kule Asude Kara Polat Aslı Akın Belli Zeynep Gökçen Kule

Abstract

Objective: Recently, the ratios of
neutrophil to lymphocyte (NL) and platelet to lymphocyte (PL) have been
used as an indicator of inflammation. We aimed to investigate the
relation of recurrent aphthous stomatitis (RAS) to inflammation by
analyzing the ratios of NL and PL.




Methods: We
conducted a case-control study on 143 patients with RAS and 134 healthy
control cases between February 2015 and March 2016. Age, sex, neutrophil
count, platelet count, lymphocyte count, and the ratios of NL and PL of
the participants were recorded.




Results: One
hundred and forty-three RAS patients and 134 control cases were
included in the study. The ratios of NL and PL of RAS group were
significantly higher than in the control group (p=0.004 and p=0.010,
respectively). The NL ratio was the only independent predictor of RAS in
multivariate logistic regression analysis (p=0.014). The cut-off value
of NL ratio for predicting RAS was 3.49 with 13.3% sensitivity and 99.9%
specificity (p=0.010).




Conclusion: We
have found that the ratios of NL and PL were higher in RAS group than
the control group. The results of our study support that inflammation
has an important role in the pathogenesis of RAS.

Keywords

Lymphocyte, neutrophil, platelet, recurrent aphthous stomatitis

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