Year 2020, Volume 10 , Issue 1, Pages 232 - 237 2020-04-25

Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene.
Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism.
Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05).
Conclusion: The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group control may indicate a protective effect in COM.

Otitis media, paraoxonase-1, genetic polymorphism, oxidative stress
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Orcid: 0000-0002-0447-1665
Author: Kasım DURMUŞ (Primary Author)
Institution: SİVAS CUMHURİYET ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0001-9172-3244
Author: Hande KÜÇÜK KURTULGAN
Institution: SİVAS CUMHURİYET ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-5036-0595
Author: Adem BORA
Institution: SİVAS CUMHURİYET ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-4386-1583
Author: Malik Ejder YILDIRIM
Institution: SİVAS CUMHURİYET ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-4503-3730
Author: Emine Elif ALTUNTAŞ
Institution: SİVAS CUMHURİYET ÜNİVERSİTESİ
Country: Turkey


Supporting Institution YOK
Dates

Application Date : July 19, 2019
Acceptance Date : September 25, 2019
Publication Date : April 25, 2020

Bibtex @research article { entupdates594272, journal = {ENT Updates}, issn = {2149-7109}, eissn = {2149-6498}, address = {}, publisher = {Sürekli Eğitim ve Bilimsel Araştırmalar Derneği}, year = {2020}, volume = {10}, pages = {232 - 237}, doi = {10.32448/entupdates.594272}, title = {An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media}, key = {cite}, author = {Durmuş, Kasım and Küçük Kurtulgan, Hande and Bora, Adem and Yıldırım, Malik Ejder and Altuntaş, Emine Elif} }
APA Durmuş, K , Küçük Kurtulgan, H , Bora, A , Yıldırım, M , Altuntaş, E . (2020). An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media . ENT Updates , 10 (1) , 232-237 . DOI: 10.32448/entupdates.594272
MLA Durmuş, K , Küçük Kurtulgan, H , Bora, A , Yıldırım, M , Altuntaş, E . "An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media" . ENT Updates 10 (2020 ): 232-237 <https://dergipark.org.tr/en/pub/entupdates/issue/53920/594272>
Chicago Durmuş, K , Küçük Kurtulgan, H , Bora, A , Yıldırım, M , Altuntaş, E . "An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media". ENT Updates 10 (2020 ): 232-237
RIS TY - JOUR T1 - An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media AU - Kasım Durmuş , Hande Küçük Kurtulgan , Adem Bora , Malik Ejder Yıldırım , Emine Elif Altuntaş Y1 - 2020 PY - 2020 N1 - doi: 10.32448/entupdates.594272 DO - 10.32448/entupdates.594272 T2 - ENT Updates JF - Journal JO - JOR SP - 232 EP - 237 VL - 10 IS - 1 SN - 2149-7109-2149-6498 M3 - doi: 10.32448/entupdates.594272 UR - https://doi.org/10.32448/entupdates.594272 Y2 - 2019 ER -
EndNote %0 ENT Updates An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media %A Kasım Durmuş , Hande Küçük Kurtulgan , Adem Bora , Malik Ejder Yıldırım , Emine Elif Altuntaş %T An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media %D 2020 %J ENT Updates %P 2149-7109-2149-6498 %V 10 %N 1 %R doi: 10.32448/entupdates.594272 %U 10.32448/entupdates.594272
ISNAD Durmuş, Kasım , Küçük Kurtulgan, Hande , Bora, Adem , Yıldırım, Malik Ejder , Altuntaş, Emine Elif . "An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media". ENT Updates 10 / 1 (April 2020): 232-237 . https://doi.org/10.32448/entupdates.594272
AMA Durmuş K , Küçük Kurtulgan H , Bora A , Yıldırım M , Altuntaş E . An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media. ENT Updates. 2020; 10(1): 232-237.
Vancouver Durmuş K , Küçük Kurtulgan H , Bora A , Yıldırım M , Altuntaş E . An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media. ENT Updates. 2020; 10(1): 232-237.