Year 2020, Volume 10 , Issue 1, Pages 244 - 250 2020-04-25

Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre

Bee See GOH [1] , Nadhirah Mohd SHAKRI [2] , Jenny Loh CHEN NEE [3]


Objective: To review the long term outcome of juvenile onset recurrent respiratory papillomatosis (JORRP) in University Kebangsaan Medical Centre (UKMMC).
Methods: A sixteen-year retrospective study – from January 2002 to June 2019 – of patients who presented with JORRP at our hospital was carried out.
Results: Nineteen cases were identified with the youngest age of presentation being eight months old. The mean follow-up time was 4.8 years. All patients had glottic papilloma, ten had multi-site involvement, namely at the subglottic, trachea, oropharynx and one case of distal spread to the lungs. The majority (71.4%) of patients with tracheostomy had extralaryngeal spread and shorter surgical intervals (a mean of 3.2 procedures per year). All our patients were treated surgically. Two patients with aggressive disease received a trial of the adjuvant therapies Gardasil and Cidofovir. However, no improvement was observed.
Conclusion: The worst prognosis is seen in younger-onset JORRP. Surgery is the mainstay of treatment and patients with aggressive disease may need adjuvant therapy. Unfortunately, there is a lack of a standard protocol for adjuvant therapies. Tracheostomy increases the risk of extralaryngeal spread and aggressive disease, and thus should be reserved for patients with severe airway compromise.
Human papillomavirus infection, respiratory tract, pediatrics, tracheostomy
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Orcid: 0000-0002-5535-2930
Author: Bee See GOH
Institution: University Kebangsaan Malaysia Medical Centre
Country: Malaysia


Author: Nadhirah Mohd SHAKRI
Institution: University Kebangsaan Malaysia Medical Centre
Country: Malaysia


Author: Jenny Loh CHEN NEE
Institution: Pantai Hospital, Ayer Keroh, Melaka, Malaysia
Country: Malaysia


Dates

Application Date : January 12, 2020
Acceptance Date : March 8, 2020
Publication Date : April 25, 2020

Bibtex @research article { entupdates673674, journal = {ENT Updates}, issn = {2149-7109}, eissn = {2149-6498}, address = {}, publisher = {Sürekli Eğitim ve Bilimsel Araştırmalar Derneği}, year = {2020}, volume = {10}, pages = {244 - 250}, doi = {10.32448/entupdates.673674}, title = {Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre}, key = {cite}, author = {Goh, Bee See and Shakrı, Nadhirah Mohd and Chen Nee, Jenny Loh} }
APA Goh, B , Shakrı, N , Chen Nee, J . (2020). Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre . ENT Updates , 10 (1) , 244-250 . DOI: 10.32448/entupdates.673674
MLA Goh, B , Shakrı, N , Chen Nee, J . "Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre" . ENT Updates 10 (2020 ): 244-250 <https://dergipark.org.tr/en/pub/entupdates/issue/53920/673674>
Chicago Goh, B , Shakrı, N , Chen Nee, J . "Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre". ENT Updates 10 (2020 ): 244-250
RIS TY - JOUR T1 - Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre AU - Bee See Goh , Nadhirah Mohd Shakrı , Jenny Loh Chen Nee Y1 - 2020 PY - 2020 N1 - doi: 10.32448/entupdates.673674 DO - 10.32448/entupdates.673674 T2 - ENT Updates JF - Journal JO - JOR SP - 244 EP - 250 VL - 10 IS - 1 SN - 2149-7109-2149-6498 M3 - doi: 10.32448/entupdates.673674 UR - https://doi.org/10.32448/entupdates.673674 Y2 - 2020 ER -
EndNote %0 ENT Updates Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre %A Bee See Goh , Nadhirah Mohd Shakrı , Jenny Loh Chen Nee %T Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre %D 2020 %J ENT Updates %P 2149-7109-2149-6498 %V 10 %N 1 %R doi: 10.32448/entupdates.673674 %U 10.32448/entupdates.673674
ISNAD Goh, Bee See , Shakrı, Nadhirah Mohd , Chen Nee, Jenny Loh . "Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre". ENT Updates 10 / 1 (April 2020): 244-250 . https://doi.org/10.32448/entupdates.673674
AMA Goh B , Shakrı N , Chen Nee J . Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre. ENT Updates. 2020; 10(1): 244-250.
Vancouver Goh B , Shakrı N , Chen Nee J . Long Term Outcome of Juvenile Onset Recurrent Respiratory Papillomatosis in University Kebangsaan Medical Centre. ENT Updates. 2020; 10(1): 244-250.