Research Article

INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS

Volume: 60 Number: 1 June 18, 2026

INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS

Abstract

Purpose: The aim of this study is to investigate the relationship between Decayed, Missing, and Filled Teeth (DMFT) scores, caries activity, and salivary characteristics (flow rate, pH, and buffering capacity) in patients admitted to the Department of Restorative Dentistry at Kocaeli University Faculty of Dentistry.

Materials and Methods: This study included 44 patients aged 18–50 years, classified into high and low caries risk groups, who presented to our clinic. A DMFT score above 8 and the presence of at least two active carious lesions with cavitation (ICDAS II Categories 5 or 6) were considered criteria for the high caries risk group. Conversely, patients with five or fewer carious or restored teeth and no active caries were classified as low caries risk. Saliva samples were collected prior to any restorative procedures. Salivary flow rate, pH, and buffering capacity were measured using the Saliva-Check Buffer Kit (GC Europe, Leuven, Belgium). The correlation between caries activity and salivary buffering capacity was analyzed using ANOVA and Kruskal–Wallis tests. Tukey’s and Mann–Whitney U tests were applied for pairwise comparisons.

Results: The highest buffering capacity was observed in the high-risk group aged 25–50 years, while the lowest was found in the high-risk group aged 18–25 years (p = 0.028). No statistically significant difference was found between the groups in terms of both unstimulated and stimulated salivary flow rates.

Conclusion: In the absence of pathological conditions, a physiologically low salivary flow rate does not appear to significantly influence caries risk. A meaningful relationship between salivary factors and caries risk becomes evident only when salivary flow is severely reduced.

Keywords

Project Number

GOKAEK-2024/17.06

Ethical Statement

Bu çalışma, GOKAEK-2024/17.06 proje numarası ile Kocaeli Üniversitesi Girişimsel Olmayan Klinik Araştırma Etik Kurulu'nun onayı ile yürütülmüştür. Bu çalışmadan önce katılımcılardan veya yasal vasilerinden ayrıntılı yazılı bilgilendirilmiş onay alınmıştır.

References

  1. Brundtland GH. From the World Health Organization. Reducing risks to health, promoting healthy life. JAMA. 2002;288:1974. [CrossRef] google scholar
  2. Zero D, Fontana M, Lennon ÁM. Clinical applications and outcomes of using indicators of risk in caries management. J Dent Educ. 2001;65:1126–32. [CrossRef] google scholar
  3. Fontana M, Santiago E, Eckert GJ, Ferreira-Zandona AG. Risk factors of caries progression in a Hispanic school-aged population. J Dent Res. 2011;90:1189–96. [CrossRef] google scholar
  4. Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, et al. Dental caries. Nat Rev Dis Primers. 2017;3:17030. [CrossRef] google scholar
  5. Klein MI, Hwang G, Santos PH, Campanella OH, Koo H. Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Front Cell Infect Microbiol. 2015;5:10. [CrossRef] google scholar
  6. Hemadi AS, Huang R, Zhou Y, Zou J. Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int J Oral Sci. 2017;9:e1. [CrossRef] google scholar
  7. Laputková G, Schwartzová V, Bánovčin J, Alexovič M, Sabo J. Salivary protein roles in oral health and as predictors of caries risk. Open Life Sci. 2018;13:174–200. [CrossRef] google scholar
  8. Chiappin S, Antonelli G, Gatti R, De Palo EF. Saliva specimen:a new laboratory tool for diagnostic and basic investigation. Clin Chim Acta. 2007;383(1-2):30–40. [CrossRef] google scholar

Details

Primary Language

English

Subjects

Restorative Dentistry

Journal Section

Research Article

Publication Date

June 18, 2026

Submission Date

November 18, 2024

Acceptance Date

February 17, 2025

Published in Issue

Year 2026 Volume: 60 Number: 1

APA
Oğhan Türkoğlu, M., Saçu, E., Yersel, G., Çakır, G. N., Turgut, V., Tekçe, N., Tuncer, S., & Demirci, M. (2026). INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS. European Oral Research, 60(1), 113-120. https://doi.org/10.26650/eor.20251584130
AMA
1.Oğhan Türkoğlu M, Saçu E, Yersel G, et al. INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS. EOR. 2026;60(1):113-120. doi:10.26650/eor.20251584130
Chicago
Oğhan Türkoğlu, Meltem, Engin Saçu, Göktuğ Yersel, et al. 2026. “INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS”. European Oral Research 60 (1): 113-20. https://doi.org/10.26650/eor.20251584130.
EndNote
Oğhan Türkoğlu M, Saçu E, Yersel G, Çakır GN, Turgut V, Tekçe N, Tuncer S, Demirci M (June 1, 2026) INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS. European Oral Research 60 1 113–120.
IEEE
[1]M. Oğhan Türkoğlu et al., “INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS”, EOR, vol. 60, no. 1, pp. 113–120, June 2026, doi: 10.26650/eor.20251584130.
ISNAD
Oğhan Türkoğlu, Meltem - Saçu, Engin - Yersel, Göktuğ - Çakır, Gaye Nur - Turgut, Vildan - Tekçe, Neslihan - Tuncer, Safa - Demirci, Mustafa. “INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS”. European Oral Research 60/1 (June 1, 2026): 113-120. https://doi.org/10.26650/eor.20251584130.
JAMA
1.Oğhan Türkoğlu M, Saçu E, Yersel G, Çakır GN, Turgut V, Tekçe N, Tuncer S, Demirci M. INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS. EOR. 2026;60:113–120.
MLA
Oğhan Türkoğlu, Meltem, et al. “INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS”. European Oral Research, vol. 60, no. 1, June 2026, pp. 113-20, doi:10.26650/eor.20251584130.
Vancouver
1.Meltem Oğhan Türkoğlu, Engin Saçu, Göktuğ Yersel, Gaye Nur Çakır, Vildan Turgut, Neslihan Tekçe, Safa Tuncer, Mustafa Demirci. INVESTIGATION OF THE RELATIONSHIP BETWEEN CARIES PREDISPOSITION AND SALIVARY CHARACTERISTICS. EOR. 2026 Jun. 1;60(1):113-20. doi:10.26650/eor.20251584130