Research Article
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Evaluation of third molar agenesis associated with hypodontia and oligodontia in turkish pediatric patients

Year 2020, Volume: 54 Issue: 3, 136 - 141, 05.01.2021
https://doi.org/10.26650/eor.20200134

Abstract

Purpose: To evaluate the association between third molar (M3) agenesis and hypodontia and oligodontia in pediatric patients by using panoramic radiography.
Materials and Methods: Panoramic radiographs of 1,471 patients (899 females; 572 males) and 5,884 teeth were retrospectively evaluated. The age and gender of the patients were recorded. Patients ages 9-15 years old were included in the study. The mean age was 12.76. The agenesis of M3 teeth and the relationship between M3 agenesis and hypodontia and oligodontia were recorded according to findings from the upper and lower jaw, in both the right and left locations, along with the number of M3 with agenesis. Data were analyzed using chi-square and McNemar tests (p<0.05).
Results: A total of 1,319 (89.7%) patients had all M3 teeth present in the mouth, while the other 152 (10.3%) had congenital agenesis in one or more teeth. The number of teeth in which M3 agenesis was seen, in order of the number of missing teeth, was one (2.6%), two (2.4%), three (1.0%) and four (4.3%). Hypodontia was detected in 37 patients and oligodontia was detected in 3 patients.
Conclusion: The prevalence of M3 agenesis varies from one population to another. One of the dental anomalies associated with M3 agenesis is hypodontia and oligodontia. In this study, M3 agenesis varied in terms of region and gender; hypodontia was also significantly higher in patients with missing mandibular M3.

Supporting Institution

The authors declared that they have received no financial support.

References

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  • 2. Kruger E, Thomson WM, Konthasinghe P. Third molar outcomes from age 18 to 26: findings from a population-based New Zealand longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92(2): 150–5.
  • 3. Gravely JF. A radiographic survey of third molar development. Br Dent J 1965; 119(9): 397–401.
  • 4. Peker I, Kaya E, Darendeliler-Yaman S. Clinic and radiographical evaluation of non-syndromic hypodontia and hyperdontia in permanent dentition. Med Oral Patol Oral Cir Bucal 2009; 14: e393-7.
  • 5. Kolenc-Fusé FJ. Tooth agenesis: in search of mutations behind failed dental development. Med Oral Patol Oral Cir Bucal 2004; 9(5): 390-5; 385-90.
  • 6. Alves-Pereira D, Berini-Aytés L, Gay-Escoda C. Ellis-van Creveld syndrome. Case report and literature review. Med Oral Patol Oral Cir Bucal 2009; 14: E340-3.
  • 7. John J, Nambiar P, Mani SA, Mohamed NH, Ahmad NF, Murad NA. Third molar agenesis among children and youths from three major races of Malaysians. J Dent Sciences 2012; 7: 211-7.
  • 8. Celikoglu M, Miloglu O, Kazanci F. Frequency of agenesis, impaction, angulation, and related pathologic changes of third molar teeth in orthodontic patients. J Oral Maxillofac Surg 2010; 68(5): 990–5.
  • 9. Goldenberg M, Das P, Messersmith M, Stockton DW, Patel PI, D'Souza RN. Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia. J Dent Res 2000; 79(7): 1469–75.
  • 10. Suda N, Ogawa T, Kojima T, Saito C, Moriyama K. Non-syndromic oligodontia with a novel mutation of PAX9. J Dent Res 2011 Mar; 90(3): 382-6.
  • 11. Jung YH, Cho BH. Radiographic evaluation of third molar development in 6- to 24-year-olds. Imaging Sci Dent 2014 Sep; 44(3): 185–91.
  • 12. Liversidge HM. Timing of human mandibular third molar formation. Ann Hum Biol 2008; 35: 294–321.
  • 13. Hentisz AY. Master's Thesis, University of Tennessee. 2003. Radiographic Study of Third Molar Agenesis in a Sample from the American Midsouth.
  • 14. Shiller WR. Positional changes in mesio-angular impacted mandibular third molars during a year. J Am Dent Assoc 1979; 99: 460-4.
  • 15. Gelgör IE, Şişman Y, Malkoç S. Daimi Dentisyonda Konjenital Hipodontinin Görülme Sıklığı. Türkiye Klinikleri Journal of Dental Science 2005; 11: 43-8.
  • 16. Sujon MK, Alam MK, Rahman SA. Prevalence of third molar agenesis: Associated dental anomalies in non-syndromic 5923 patients. PLoS One 2016; 11: e0162070.
  • 17. Garn SM, Lewis AB, Vicinus JH. Third molar agenesis and reduction in the number of other teeth. J Dent Res 1962; 41: 717.
  • 18. Mishra A, Pandey RK. Sexual dimorphism, pattern of third molar and mandibular second premolar agenesis in Indian paediatric orthodontic patients. Saudi Dent J 2017; 29(2): 78-82.
  • 19. Kaur B, Sheik S, Pallagatti S. Radiographic assessment of agenesis of third molars and para-radicular third molar radiolucencies in population of age group 18-25 years old – a radiographic survey. Arch Oral Res 2012; 8: 13-8.
  • 20. Upadhyaya C, Adhikari BR, Kafle D, Humagain M. Agenesis of orthodontic patients attending Dhulikhel Hospital, Kathmandu University Hospital. Dhulikhel, Nepal. Orthod J Nepal 2012; 2(1): 33–6.
  • 21. Sandhu S, Kaur T. Radiographic evaluation of the status of third molars in the Asian-Indian students. J Oral Maxillofac Surg 2005; 66: 640-5.
  • 22. Mok YY, Ho KK. Congenitally absent third molars in 12–16 years old Singaporean-Chinese patients: a retrospective radiographic study. Ann Acad Med Singapore 1996; 25: 828-30.
  • 23. Endo T, Ozoe R, Kubota M, Akiyama M, Shimooka S. A survey of hypodontia in Japanese orthodontic patients. Am J Orthod Dentofacial Orthop 2006; 129: 29-35.
  • 24. Chung CJ, Han JH, Kim KH. The pattern and prevalence of hypodontia in Koreans. Oral Dis 2008;14: 620-5.
  • 25. Celikoglu M, Kamak H. Patterns of third-molar agenesis in an orthodontic patient population with different skeletal malocclusions. Angle Orthod 2012; 82: 165-9.
  • 26. Alam MK, Hamza MA, Khafiz MA, Rahman SA, Shaari R, Hassan A. Multivariate analysis of factors affecting presence and/or agenesis of third molar tooth. PLoS ONE 2014; 9 (6): e101157.
  • 27. Celikoglu M, Bayram M, Nur M. Patterns of third-molar agenesis and associated dental anomalies in an orthodontic population. Am J Orthod Dentofac Orthop 2011; 140: 856-60.
  • 28. Endo S, Sanpei S, Ishida R, Sanpei S, Abe R, Endo T. Association between third molar agenesis patterns and agenesis of other teeth in a Japanese orthodontic population. Odontology 2015; 103: 89–96.
  • 29. Moreno MT, Díaz A, González A, Manríquez-Soto G, Toro-Ibacache V. Is Third Molar Agenesis an Anomaly or Just a Sign of Variation? Prevalence and Manner of Presentation of this Condition in a Sample from the Metropolitan Region of Chile. Int J Morphol 2019; 37(4): 1382–6.
  • 30. Singh N, Chaudhari S, Chaudhari R, Nagare S, Kulkarni A, Parkarwar P. A radiographic survey of agenesis of the third molar: a panoramic study. J Forensic Dent Sci 2017; 9(3): 130–134.
  • 31. Kilinç G, Akkemik OK, Candan U, Evcil MS, Ellidokuz H. Agenesis of third molars among Turkish children between the ages of 12 and 18 years: A retrospective radiographic study. J Clin Pediatr Dent 2017; 41 (3): 243-7.
  • 32. Thompson GW, Popovigh F, Anderson DL. Third molar agenesis in the Burlington Growth Centre in Toronto. Community Dent Oral Epidemiol 1974; 2: 187–92.
  • 33. Gulati S, Singla D, Mittal S, Bhullar M, Aggarwal I, Sharma A. Relationship between Third Molar Agenesis and Other Dental Anomalies. Dent J Adv Stud 2019; 7: 23–7.
  • 34. Akkaya N, Kiremitçi A, Kansu O. Treatment of a patient with oligodontia: a case report. J Contemp Dent Pract 2008 Mar 1; 9(3): 121–7.
  • 35. Nanda RS. Agenesis of the third molar in man. Am J Orthod 1954; 40: 698-706.
  • 36. Levesque GY, Demirijian A, Tanguay R. Sexual dimorphism in the development, emergence, and agenesis of the mandibular third molar. J Dent Res 1981; 60: 1735- 41.
  • 37. Rozkovcová E, Marková M, Lanik J, Zvárová J. Agenesis of third molars in young Czech population. Prague Med Rep 2004;105: 35-52.
  • 38. Lee SH, Lee JY, Park HK, Kim YK. Development of third molars in Korean juveniles and adolescents. Forensic Sci Int 2009; 188: 107-11.
  • 39. Kazanci F, Celikoglu M, Miloglu O, Oktay H. Third-molar agenesis among patients from the East Anatolian region of Turkey. J Contemp Dent Pract 2010;11(4): E033–E040.
Year 2020, Volume: 54 Issue: 3, 136 - 141, 05.01.2021
https://doi.org/10.26650/eor.20200134

Abstract

References

  • 1. Cameron J, Sampson WJ. Hypodontia of the permanent dentition. Aust Dent J 1996; 41(1): 1–5.
  • 2. Kruger E, Thomson WM, Konthasinghe P. Third molar outcomes from age 18 to 26: findings from a population-based New Zealand longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92(2): 150–5.
  • 3. Gravely JF. A radiographic survey of third molar development. Br Dent J 1965; 119(9): 397–401.
  • 4. Peker I, Kaya E, Darendeliler-Yaman S. Clinic and radiographical evaluation of non-syndromic hypodontia and hyperdontia in permanent dentition. Med Oral Patol Oral Cir Bucal 2009; 14: e393-7.
  • 5. Kolenc-Fusé FJ. Tooth agenesis: in search of mutations behind failed dental development. Med Oral Patol Oral Cir Bucal 2004; 9(5): 390-5; 385-90.
  • 6. Alves-Pereira D, Berini-Aytés L, Gay-Escoda C. Ellis-van Creveld syndrome. Case report and literature review. Med Oral Patol Oral Cir Bucal 2009; 14: E340-3.
  • 7. John J, Nambiar P, Mani SA, Mohamed NH, Ahmad NF, Murad NA. Third molar agenesis among children and youths from three major races of Malaysians. J Dent Sciences 2012; 7: 211-7.
  • 8. Celikoglu M, Miloglu O, Kazanci F. Frequency of agenesis, impaction, angulation, and related pathologic changes of third molar teeth in orthodontic patients. J Oral Maxillofac Surg 2010; 68(5): 990–5.
  • 9. Goldenberg M, Das P, Messersmith M, Stockton DW, Patel PI, D'Souza RN. Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia. J Dent Res 2000; 79(7): 1469–75.
  • 10. Suda N, Ogawa T, Kojima T, Saito C, Moriyama K. Non-syndromic oligodontia with a novel mutation of PAX9. J Dent Res 2011 Mar; 90(3): 382-6.
  • 11. Jung YH, Cho BH. Radiographic evaluation of third molar development in 6- to 24-year-olds. Imaging Sci Dent 2014 Sep; 44(3): 185–91.
  • 12. Liversidge HM. Timing of human mandibular third molar formation. Ann Hum Biol 2008; 35: 294–321.
  • 13. Hentisz AY. Master's Thesis, University of Tennessee. 2003. Radiographic Study of Third Molar Agenesis in a Sample from the American Midsouth.
  • 14. Shiller WR. Positional changes in mesio-angular impacted mandibular third molars during a year. J Am Dent Assoc 1979; 99: 460-4.
  • 15. Gelgör IE, Şişman Y, Malkoç S. Daimi Dentisyonda Konjenital Hipodontinin Görülme Sıklığı. Türkiye Klinikleri Journal of Dental Science 2005; 11: 43-8.
  • 16. Sujon MK, Alam MK, Rahman SA. Prevalence of third molar agenesis: Associated dental anomalies in non-syndromic 5923 patients. PLoS One 2016; 11: e0162070.
  • 17. Garn SM, Lewis AB, Vicinus JH. Third molar agenesis and reduction in the number of other teeth. J Dent Res 1962; 41: 717.
  • 18. Mishra A, Pandey RK. Sexual dimorphism, pattern of third molar and mandibular second premolar agenesis in Indian paediatric orthodontic patients. Saudi Dent J 2017; 29(2): 78-82.
  • 19. Kaur B, Sheik S, Pallagatti S. Radiographic assessment of agenesis of third molars and para-radicular third molar radiolucencies in population of age group 18-25 years old – a radiographic survey. Arch Oral Res 2012; 8: 13-8.
  • 20. Upadhyaya C, Adhikari BR, Kafle D, Humagain M. Agenesis of orthodontic patients attending Dhulikhel Hospital, Kathmandu University Hospital. Dhulikhel, Nepal. Orthod J Nepal 2012; 2(1): 33–6.
  • 21. Sandhu S, Kaur T. Radiographic evaluation of the status of third molars in the Asian-Indian students. J Oral Maxillofac Surg 2005; 66: 640-5.
  • 22. Mok YY, Ho KK. Congenitally absent third molars in 12–16 years old Singaporean-Chinese patients: a retrospective radiographic study. Ann Acad Med Singapore 1996; 25: 828-30.
  • 23. Endo T, Ozoe R, Kubota M, Akiyama M, Shimooka S. A survey of hypodontia in Japanese orthodontic patients. Am J Orthod Dentofacial Orthop 2006; 129: 29-35.
  • 24. Chung CJ, Han JH, Kim KH. The pattern and prevalence of hypodontia in Koreans. Oral Dis 2008;14: 620-5.
  • 25. Celikoglu M, Kamak H. Patterns of third-molar agenesis in an orthodontic patient population with different skeletal malocclusions. Angle Orthod 2012; 82: 165-9.
  • 26. Alam MK, Hamza MA, Khafiz MA, Rahman SA, Shaari R, Hassan A. Multivariate analysis of factors affecting presence and/or agenesis of third molar tooth. PLoS ONE 2014; 9 (6): e101157.
  • 27. Celikoglu M, Bayram M, Nur M. Patterns of third-molar agenesis and associated dental anomalies in an orthodontic population. Am J Orthod Dentofac Orthop 2011; 140: 856-60.
  • 28. Endo S, Sanpei S, Ishida R, Sanpei S, Abe R, Endo T. Association between third molar agenesis patterns and agenesis of other teeth in a Japanese orthodontic population. Odontology 2015; 103: 89–96.
  • 29. Moreno MT, Díaz A, González A, Manríquez-Soto G, Toro-Ibacache V. Is Third Molar Agenesis an Anomaly or Just a Sign of Variation? Prevalence and Manner of Presentation of this Condition in a Sample from the Metropolitan Region of Chile. Int J Morphol 2019; 37(4): 1382–6.
  • 30. Singh N, Chaudhari S, Chaudhari R, Nagare S, Kulkarni A, Parkarwar P. A radiographic survey of agenesis of the third molar: a panoramic study. J Forensic Dent Sci 2017; 9(3): 130–134.
  • 31. Kilinç G, Akkemik OK, Candan U, Evcil MS, Ellidokuz H. Agenesis of third molars among Turkish children between the ages of 12 and 18 years: A retrospective radiographic study. J Clin Pediatr Dent 2017; 41 (3): 243-7.
  • 32. Thompson GW, Popovigh F, Anderson DL. Third molar agenesis in the Burlington Growth Centre in Toronto. Community Dent Oral Epidemiol 1974; 2: 187–92.
  • 33. Gulati S, Singla D, Mittal S, Bhullar M, Aggarwal I, Sharma A. Relationship between Third Molar Agenesis and Other Dental Anomalies. Dent J Adv Stud 2019; 7: 23–7.
  • 34. Akkaya N, Kiremitçi A, Kansu O. Treatment of a patient with oligodontia: a case report. J Contemp Dent Pract 2008 Mar 1; 9(3): 121–7.
  • 35. Nanda RS. Agenesis of the third molar in man. Am J Orthod 1954; 40: 698-706.
  • 36. Levesque GY, Demirijian A, Tanguay R. Sexual dimorphism in the development, emergence, and agenesis of the mandibular third molar. J Dent Res 1981; 60: 1735- 41.
  • 37. Rozkovcová E, Marková M, Lanik J, Zvárová J. Agenesis of third molars in young Czech population. Prague Med Rep 2004;105: 35-52.
  • 38. Lee SH, Lee JY, Park HK, Kim YK. Development of third molars in Korean juveniles and adolescents. Forensic Sci Int 2009; 188: 107-11.
  • 39. Kazanci F, Celikoglu M, Miloglu O, Oktay H. Third-molar agenesis among patients from the East Anatolian region of Turkey. J Contemp Dent Pract 2010;11(4): E033–E040.
There are 39 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Original Research Articles
Authors

Meltem Tekbas Atay This is me 0000-0002-1762-830X

Neslihan Ozveren This is me 0000-0002-1090-5415

Gozde Serindere This is me 0000-0001-7439-3554

Publication Date January 5, 2021
Submission Date December 3, 2019
Published in Issue Year 2020 Volume: 54 Issue: 3

Cite

EndNote Tekbas Atay M, Ozveren N, Serindere G (January 1, 2021) Evaluation of third molar agenesis associated with hypodontia and oligodontia in turkish pediatric patients. European Oral Research 54 3 136–141.