DNA Profiling of ING1 Gene in Triple Negative Breast Cancer

Abstract

Breast cancer is among the most common cancers and the second in death caused from cancers in women. Triple negative breast cancer (TNBC) is a subgroup which not expressed estrogen (ER), progesterone (PR) and HER2 receptors in breast cancer. It has 15% rate of all breast cancer and has been more aggressive and has poor prognosis. For this reason, early diagnosis has a key role because of TNBC’s high relapse. Investigation of DNA methylation pattern in TNBC likewise all types of breast cancer has become an important prognostic vehicle besides assessment of gene expression profile in diagnosis cancer subtypes. DNA methylation pattern of tumor suppressor genes which is one of the epigenetic modifications has highly importance. In this study, we aimed to investigate the relationship DNA methylation pattern of ING1 (inhibitor of growth family member 1), a tumor suppressor gene and TNBC. For this purpose, we searched the methylation pattern of ING1 and breast cancer patients especially TNBC. As a result, we discussed and tried to clarified the relationship between epigenetic modifications of ING1 gene and TNBC.

Keywords

• Breast cancer
• Triple negative breast cancer
• Epigenetic factors
• DNA methylation
• ING1 gene

References

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