Synthesis of Piperazine Functionalized Calix[4]Arene-1,8-Naphthalimidine Derivatives and Preparation of Antimicrobial Transparent Biofilms
Abstract
In supramolecular chemistry, calix[n]arenes, known as the “third generation” host molecules after crown ethers and cyclodextrins, are important macrocyclic compounds (Neri et al., 2016). Calix[n]arenes are macrocyclic molecules containing phenolic rings bridged by methylene groups and are known for their ability to form inclusion complexes or act as molecular scaffolds (Fateh et al., 2021; Migliore et al., 2021). In recent years, it has been proven by various studies that some calix[n]arene derivatives are suitable for bioactivity studies. In this study, three new fluorescent calix[4]arene derivatives were formed and characterized by reacting calix[4]arene with 4-bromo-1,8-naphthalanhydride and then replacing the bromine in the naphthyl groups with piperase derivatives. These synthesized fluorescent compounds were reacted with hyaluronic acid to form transparent biofilm, and FE-SEM and EDX analyses were performed to determine the surface profiles of these prepared antimicrobial transparent biofilms. Among the synthesized compounds, compound number 7 showed significant antimicrobial activity on Sarcian lutea at a dose of 0.097 mg/ml and also, this MIC value was reported as the lowest value recorded in the entire study.
Keywords
References
- Yilmaz, M. Yildirim, A., & Uysal, A. (2025). Synthesis of piperazine functionalized calix[4]arene-1,8- naphthalimidine derivatives and preparation of antimicrobial transparent biofilms. The Eurasia Proceedings of Science, Technology, Engineering and Mathematics (EPSTEM), 35, 297-301.
Details
Primary Language
English
Subjects
Chemical Engineering Design , Chemical Reaction
Journal Section
Conference Paper
Early Pub Date
October 20, 2025
Publication Date
September 30, 2025
Submission Date
April 15, 2025
Acceptance Date
May 26, 2025
Published in Issue
Year 2025 Volume: 35
APA
Yılmaz, M., Yıldırım, A., & Uysal, A. (2025). Synthesis of Piperazine Functionalized Calix[4]Arene-1,8-Naphthalimidine Derivatives and Preparation of Antimicrobial Transparent Biofilms. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 35, 297-301. https://doi.org/10.55549/epstem.1806625