Investigation of Red Blood Cell Microcirculation Using the DLVO Theory

Lali Kalandadze; Nugzar Gomidze; Mirian Kontselidze

Investigation of Red Blood Cell Microcirculation Using the DLVO Theory

Abstract

The study of blood microcirculation has revealed specific properties that distinguish blood from Newtonian and non-Newtonian fluids. These anomalies cannot be fully explained by conventional hydrodynamic or rheological models alone. While the viscous incompressible fluid model describes blood flow well in vessels with diameters exceeding 300 µm, capillaries below this threshold exhibit non-classical flow behavior, the underlying physical mechanisms of which remain an active area of investigation. In this work, blood is modeled as a multiphase physicochemical system, represented as a suspension of cellular elements in plasma. The cellular components, particularly erythrocytes, are treated as part of an electrostatic system, where their electrical characteristics are determined not by discrete surface charges, but by the zeta potential -the electrokinetic potential at the interface between the erythrocyte membrane and the plasma. Microcirculatory dynamics are analyzed through the framework of DLVO theory. A quantitative assessment of red blood cell motion in capillaries is presented, incorporating resistance forces, hydrodynamic pressure, and gradients in electrostatic potential. The results indicate that mechanical and electrical factors substantially influence microcirculatory flow, affecting erythrocyte deformation and orientation, and inducing a directional electrostatic force gradient that governs cell movement in narrow capillaries.

Keywords

References

Kalandadze, L., Gomidze, N. & Kontselidze, M. (2025). Investigation of red blood cell microcirculation using the DLVO theory. The Eurasia Proceedings of Science, Technology, Engineering and Mathematics (EPSTEM), 36, 73-80.

Details

Primary Language

English

Subjects

Classical Physics (Other)

Journal Section

Research Article

Authors

Lali Kalandadze This is me
Georgia

Nugzar Gomidze This is me
Georgia

Mirian Kontselidze This is me
Georgia

Early Pub Date

October 31, 2025

Publication Date

-

Submission Date

July 1, 2025

Acceptance Date

August 5, 2025

Published in Issue

Year 2025 Volume: 36

IZ

https://izlik.org/JA97BM85PT

Cite

RIS / Bibtex

APA

Kalandadze, L., Gomidze, N., & Kontselidze, M. (2025). Investigation of Red Blood Cell Microcirculation Using the DLVO Theory. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 36, 73-80. https://izlik.org/JA97BM85PT