The Preparatıon of Gelatin Coated Sodium Alginate Hydrogels

Abstract

In this study, a series of gelatin coated sodium alginate (Na-Alg) hydrogels were prepared. Firstly, three types of hydrogels in bead form were obtained by using the classical ionic crosslinking method of Na-Alg with calcium chloride (CaCl₂). Second group was a series of Na-Alg hydrogel beads coated with gelatin. The immersing method was used to get the coated beads. The hydrogel samples were diversified by changing the concentrations of gelatin and CaCl₂ solutions. The percentages of Na-Alg solution was kept constant at 10%. Swelling tests of all hydrogel beads were gravimetrically carried out in buffer solution at pH=7.0 and swelling percentages were calculated.  It is found that swelling value is decreased by increasing of CaCl₂ from 5% to 30%. In general, the hydrogels prepared using 5% of crosslinker were unstable. Coating conditions of Na-Alg hydrogel were varied by changing gelatin concentrations from 10% to 20%. The increasing amount of gelatin in coated part causes the decreasing in swelling values of hydrogel beads.

Keywords

• Hydrogel,Sodium alginate,Gelatin,Swelling,Sequentially releasing

References

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