Use of Platelet Derived Blood Concentrates in Oral and Maxillofacial Surgery

Abstract

Today, with the development of new technologies in the field of dentistry can benefit from a variety of different methods. Platelet rich concentration agents obtained from the patient's autogenous blood. Various treatment approaches have been formed with the studies conducted today in the applications of whole blood concentrates. Once reported to be effective in wound healing and bone formation, it is widely used in the dentistry. The use of these concentrates, which are used in many fields in medicine, has been increasing in recent years in dentistry. Even if the research is mostly in the field of medicine; a large number of studies have also been conducted in oral and maxillofacial surgery. It provides angiogenesis, osteogenesis, fibroplasia and cell proliferation with the growth factors contained in it; due to this, it has an important role in wound healing and regeneration, which makes it preferable to use in other areas of dentistry such as endodontics and periodontology. Positive results have also been reported in many applications such as sinus lifting, bone augmentations, soft tissue applications, and wound healing after tooth extractions in oral surgery due to this effect of platelet concentrates. In this review, we aim to describe the history, development and applications of platelet concentrations in the oral and maxillofacial surgery branch.

Keywords

• Platelet rich fibrin
• platelet rich plasma
• sinus lifting
• growth factor
• regeneration
• oral and maxillofacial surgery

Oral ve Maksillofasiyal Cerrahide Trombosit Konsantrelerinin Kullanımı

Abstract

Günümüzde yeni teknolojilerin gelişmesiyle diş hekimliği alanında birçok farklı tedavi yöntemi klinik uygulamalar arasına girmektedir. Hastanın otojen kanından elde edilen trombositten zengin konsantrasyon içerikli ajanlar da yara iyileşmesinde kullanılmaya başlanan son dönem yeniliklerinden biridir. Tam kan konsantreleri uygulamalarında günümüzde yapılan çalışmalarla çeşitli tedavi yaklaşımları oluşmuştur. Tıpta birçok alanda faydalanılan bu konsantrelerin kullanımı; diş hekimliğinde de son yıllarda artarak yaygınlaşmaktadır. Araştırmalar daha çok tıp alanında olsa dahi; ağız-diş ve çene cerrahisinde de fazla sayıda çalışma yapılmıştır. İçeriğinde bulunan büyüme faktörleri sayesinde anjiyogenez, osteogenesis, fibroplazi ve hücre proliferasyonu sağlaması; buna bağlı olarak yara iyileşmesi ve rejenerasyonda önemli role sahip olması endodonti ve periodontoloji gibi diş hekimliğinin diğer alanlarında da kullanımını cazip hale getirmektedir. Trombosit konsantrelerinin bu etkisiyle oral cerrahide sinus lifting, kemik augmentasyonları, yumuşak doku uygulamaları, çekim sonrası yara iyileşmeleri gibi birçok uygulamada da olumlu sonuçlar rapor edilmiştir. Bu derlemede oral ve maksillofasiyel cerrahi branşında trombosit konsantrasyonlarının tarihçesini, gelişimini ve uygulamalarını anlatmak amaçlanmaktadır.

Keywords

• Plateletten zengin fibrin
• plateletten zengin plazma
• sinus lifting
• büyüme faktörleri
• rejenerasyon
• oral ve maksillofasiyel cerrahi

References

1. Alexandra Stähli Franz Josef Strauss Reinhard Gruber. The use of platelet‐rich plasma to enhance the outcomes of implant therapy: A systematic review. Clin Oral Impl Res. 2018;29(Suppl. 18):20–36
2. Bajaj P, Agarwal E, Rao NS, Naik SB, Pradeep AR, Kalra N, Priyanka N, Kumari M. Autologous Platelet-Rich Fibrin in the Treatment of 3-Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial. J Periodontol. 2017;88(11): 1186-1191.
3. Bianchi, Serena & Torge, Diana & Rinaldi, Fabiola & Piattelli, Maurizio & Bernardi, Sara & Varvara, Giuseppe. (2022). Platelets’ Role in Dentistry: From Oral Pathology to Regenerative Potential. Biomedicines. 10. 218. 10.3390/biomedicines10020218.
4. Boora P, Rathee M, Bhoria M. Effect of Platelet Rich Fibrin (PRF) on peri-implant soft tissue and crestal bone in one-stage implant placement: a randomized controlled trial. J Clin Diagn Res 2015;9(4):ZC18-21.
5. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3): e56-60.
6. Deborah Chicharro-Alcántara, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M. Carrillo-Poveda,Belén Cuervo-Serrato,Pau Peláez-Gorrea and Joaquín J. Sopena-Juncosa. Platelet Rich Plasma: New Insights for CutaneousWound Healing Management. Journal of Functional Biomaterials. J Funct Biomater. 2018 Mar; 9(1): 10
7. Del Fabbro M, Gallesio G, Mozzati M. Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature. European Journal of Cancer. 2015;51(1):62-74
8. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3): e37-44.

9. Dong C, Sun Y, Qi Y, Zhu Y, Wei H, Wu D, Li C. Effect of Platelet-Rich Plasma Injection on Mild or Moderate Carpal Tunnel Syndrome: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Biomed Res Int. 2020 Nov
10. Durmuş AS, Can HN. Platelet-Rich Fibrin and Its Usage in Orthopaedic Surgery: Review. Tur Klin J of Veterinary Sciences. 2016;7(1): 24-29.
11. Elham A. Masoudi, João Ribas, Gaurav Kaushik,Jeroen Leijten, Ali Khademhosseini. Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration. Stem cells and nanotechnologies (T Kyriakides, Section Editor, Springer International Publishing 2016)
12. Gabriela Fernandes and Shuying Yang Application of platelet-rich plasma with stem cells in boneand periodontal tissue engineering. Bone Res. 2016; 4: 16036.
13. Gönül O , Çiçek A. U. , Afat M. , Atali O. , Uğurlu F. . Contemporary Overview of Blood Concentrates in Oral and Maxillacial Surgery. In: Sridharan, G. editor. Oral and Maxillofacial Surgery London: IntechOpen; 2020
14. Gül en U, Sentürk MF, Mehdiyev. Flap-free treatment of an oro-antral communication with platelet-rich fibrin. The British Association of Oral and Maxillofacial Surgeons. Accepted 30 September 2015.
15. Hehn J, Schwenk T, Striegel M, et al. The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: Results of a randomized, controlled clinical trial. International Journal of Implant Dentistry. 2016;2(1):13
16. Jian Xu, Lingshan Gou, Peng Zhang, Hongwen Li, Shuqi Qiu. Platelet-rich plasma and regenerative dentistry. Australian Dental Journal 2020; 0: 1–12
17. Miron RJ, Dham A, Dham U, Zhang Y, Pikos MA, Sculean A. The effect of age, gender, and time between blood draw and start of centrifugation on the size outcomes of platelet-rich fibrin (PRF) membranes. Clin Oral Investig. 2018.
18. Nauta A, Gurtner G, Longaker MT. Wound healing and regenerative strategies. Oral Dis. 2011;17(6): 541-549.
19. Naveed Baloch, Obada Hasan, Zain Baig, Umme-e-Hani Abdullah, Mohammad Atif, Hiroshi Ohuchi (The Aga Khan University Hospital, Karachi-Pakistan), Ghurki Trust (Teaching Hospital, Lahore-Pakistan). Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article. Orthopedic Reviews 2019; volume 11:7747
20. Nikil Kumar Jain, M.D.S., Minkle Gulati, M.D.S. Platelet-rich plasma: a healing virtuoso. Blood Res 2016; 51:3-5
21. Preeja C, Arun S. Platelet-rich fibrin: Its role in periodontal regeneration. The Saudi J for Dental Research. 2014;5(2): 117-122.
22. Rachita Dhurat and MS Sukesh. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014 Oct-Dec; 7(4): 189 197
23. Rao SG, Bhat P, Nagesh KS, Rao GHR, Mirle B, Kharbhari L, Gangaprasad B. Bone Regeneration in Extraction Sockets with Autologous Platelet Rich Fibrin Gel. J. Maxillofac. Oral Surg 2013, 12(1): 11-16
24. Ross, Russell, et al. "A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro." Proceedings of the National Academy of Sciences 71.4 (1974): 1207-1210.
25. Shawky H, Seifeldin SA. Does platelet-rich fibrin enhance bone quality and quantity of alveolar cleft reconstruction? Cleft Palate Craniofac J 2016;53(5):597-606.
26. Soni R, Priya A, Yadav H, Mishra N, Kumar L. Bone augmentation with sticky bone and platelet-rich fibrin by ridge-split technique and nasal floor engagement for immediate loading of dental implant after extracting impacted canine. Natl J Maxillofac Surg. 2019 Jan-Jun;10(1):98-101.
27. Toeroek R, Dohan Ehrenfest DM The concept of Screw-Guided Bone Regeneration (S-GBR). Part 3: Fast ScrewGuided Bone Regeneration (FS-GBR) in the severely resorbed preimplant posterior mandible using allograft and Leukocyte- and Platelet- Rich Fibrin (L PRF): a 4-year follow-up. POSEIDO. 2013; 1(2): 93-100.