Silver Diamine Fluoride in Pediatric Dentistry

Abstract

Although a decrease in the prevalence of dental caries, which is a chronic disease, has been reported in many developed countries, early childhood caries (ECC) as an early childhood disease is common, especially in developing countries. Silver diamine fluoride (SDF) stops dental caries, prevents the formation of dental caries and reduces tooth sensitivity. The biggest feature that distinguishes SDF from other fluoride agents that prevent caries formation is that it effectively stops the caries process. This effect is provided by the synergistic effect of silver ions and fluoride. As a result of clinical studies, the use of SDF at the rate of 38% is recommended for the most effective result. SDF is becoming more popular as a practical and affordable treatment option to stop caries. SDF, especially during the pandemic period when minimal aerosol production is important; can be routinely experienced in a pediatric dental office in a variety of clinical scenarios for both primary and permanent teeth. It can be used effectively and efficiently in different behavior patterns of children and in different age groups. In this review, the effect mechanism, usage areas, clinical uses and results of SDF will be evaluated in the light of current literatures.

Keywords

• silver diamine fluoride
• caries
• remineralization

Çocuk Diş Hekimliğinde Gümüş Diamin Florür

Abstract

Gelişmiş ülkelerin birçoğunda kronik bir hastalık olan diş çürüğü prevelansında azalma rapor edilmesine rağmen, özellikle gelişmekte olan ülkelerde bir erken çocukluk dönemi hastalığı olarak erken çocukluk çağı çürükleri (EÇÇ) yaygın olarak görülmektedir. Gümüş diamin florür (GDF) diş çürüklerini durdurma, diş çürüklerinin oluşmasını önleme ve diş hassasiyetinin azalmasını sağlama gibi özellikleri nedeni ile son yıllarda oldukça ilgi görmektedir. Çürük oluşumunu önleme etkisi olan diğer florür ajanlarından GDF’yi ayıran en büyük özellik çürük sürecini etkin bir şekilde durdurmasıdır. Bu etki içeriğindeki gümüş iyonlarıyla flor iyonlarının sinerjist etkisiyle sağlanmaktadır. Klinik çalışmalar sonucu en etkin sonuç için %38 oranındaki GDF kullanımı önerilmektedir. Çürük lezyonlarını durdurmak için pratik ve uygun fiyatlı bir tedavi seçeneğidir. GDF, özellikle minimum aerosol üretiminin önemli olduğu pandemi döneminde; hem süt hem de sürekli dişler için çeşitli rutin kullanıma girmiş olup farklı yaş gruplarında etkili ve verimli bir şekilde kullanılabilmektedir. Bu derlemede, GDF’nin etki mekanizması, kullanım alanları, klinik uygulama ve sonuçları mevcut literatürler ışığında değerlendirilecektir.

Keywords

• gümüş diamin florür
• diş çürükleri
• diş remineralizasyonu

References

1. Abhishek Soni, Sanchit Paul, Priyanka Sachdeva, Silver diamine fluoride as a minimally invasive and aerosol free approach in pediatric dentistry: An extensive case series, Contemp Pediatr Dent 2021:2(2):42-54
2. Alvear Fa B, Jew JA, Wong A, et al. Silver Modified Atraumatic Restorative Technique (SMART): an alternative caries prevention tool. Stomatology Edu Journal. 2016;3:243-248
3. Andropoulos DB, Greene MF. Anesthesia and Developing Brains - Implications of the FDA Warning. N Engl J Med. 2017 Mar 9;376(10):905-907.
4. Chibinski AC, Wambier LM, Feltrin J, Loguercio AD, Wambier DS, Reis A. Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis. Caries Res. 2017;51(5):527-541.
5. Clemens J, Gold J, Chaffin J. Effect and acceptance of silver diamine fluoride treatment on dental caries in primary teeth. J Public Health Dent 2018;78:63-68
6. Cohen JG, Greenwall L, Barry S. Silver diamine fluoride - an overview of the literature and current clinical techniques. Br Dent J. 2020;228(11):831–8.
7. Crystal YO, Janal MN, Hamilton DS, Niederman R. Parental perceptions and acceptance of silver diamine fluoride staining. J Am Dent Assoc. 2017 Jul;148(7):510-518.e4. doi: 10.1016/j.adaj.2017.03.013. Epub 2017 Apr 27
8. Featherstone JD. The science and practice of caries prevention. J Am Dent Assoc. 2000;131(7):887-99

9. Gao SS, Zhang S, Mei ML, Lo EC, Chu CH. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. BMC Oral Health. 2016 Feb 1;16:12.
10. Griffith, M. Deep caries and silver diamine fluoride featured, Journal California Dental Association, January 2021
11. Grossi, J.d., Cabral, R.N., Ribeiro, A.P.D. et al. Glass hybrid restorations as an alternative for restoring hypomineralized molars in the ART model. BMC Oral Health 18, 65 (2018)
12. Horst JA, Ellenikiotis H, Milgrom PL. UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent. J Calif Dent Assoc. 2016;44(1):16-28
13. Horst JA. Silver Fluoride as a treatment for dental caries. Adv Dent Res 2018;29:135‐140
14. Irene Shuping Zhao, May Lei Mei, Michael F. Burrow, Edward Chin-Man Lo, Chun-Hung Chu, Effect of Silver Diamine Fluoride and Potassium Iodide Treatment on Secondary Caries Prevention and Tooth Discolouration in Cervical Glass Ionomer Cement Restoration, Int. J. Mol. Sci. 2017,18, 340
15. Jeanette MacLean, Minimally Invasive Treatment for Molar Incisor Hypomineralization, Decisions in Dentistry November 2018
16. Jeremy A, Horst H. UCSF Silver Caries Arrest Committee PMM. USCF Protocol for Silver Diamine Fluoride. Physiol Behav. 2016;176(3):139–87.
17. KF Roberts-Thomson, DH Ha, S Wooley, S Meihubers, LG Do, Community trial of silver fluoride treatment for deciduous dentition caries in remote Indigenous communities, Australian Dental JournalVolume 64, Issue 2 p. 175-180,2019
18. Lansdown AB. Silver in health care: antimicrobial effects and safety in use. Curr Probl Dermatol. 2006;33:17-34.
19. Lavanya SJ, Arangannal P, Jeevarathan J, Amudha S. When and Where to use and not to use SDF ? - overview. Eur J Mol Clin Med. 2020;7(2):6567–72
20. Lou YL, Botelho MG, Darvell BW. Reaction of silver diamine [corrected] fluoride with hydroxyapatite and protein. J Dent. 2011 Sep;39(9):612-8.
21. Natarajan D. Silver Modified Atraumatic Restorative Technique: A Way Towards “SMART” Pediatric Dentistry During the COVID-19 Pandemic. Front Dent. 2022;19.
22. Nelson T, Scott JM, Crystal YO, Berg JH, Milgrom P. Silver Diamine Fluoride in Pediatric Dentistry Training Programs: Survey of Graduate Program Directors. Pediatr Dent. 2016;38(3):212-7
23. Ng E, Saini S, Schulze KA, Horst J, Le T, Habelitz S. Shear Bond Strength of Glass Ionomer Cement to Silver Diamine Fluoride-Treated Artificial Dentinal Caries. Pediatr Dent. 2020 May 15;42(3):221-225
24. Panahpour Eslami N, Chan DCN, Sadr A. Effect of silver diammine fluoride and glass ionomer on remineralisation of natural dentine caries. J Dent. 2021 Mar;106:103578
25. Peng JJ, Botelho MG, Matinlinna JP. Silver compounds used in dentistry for caries management: a review. J Dent. 2012;40:531-541.
26. Pérez-Hernández J, Aguilar-Díaz FC, Venegas-Lancón RD, Gayosso CAÁ, Villanueva-Vilchis MC, de la Fuente-Hernández J. Effect of silver diamine fluoride on adhesion and microleakage of a pit and fissure sealant to tooth enamel: in vitro trial. Eur Arch Paediatr Dent. 2018 Dec;19(6):411-416.
27. Pradeepika Liyana Arachchige A, Sultan A, Herath C. Silver diamine fluoride for early childhood caries- A boon for dentists during COVID-19 pandemic. Int J Oral Health Dent 2021;7(3):161-165.
28. Puwanawiroj A, Trairatvorakul C, Dasanayake AP, Auychai P. Microtensile Bond Strength Between Glass Ionomer Cement and Silver Diamine Fluoride-Treated Carious Primary Dentin. Pediatr Dent. 2018 Jul 15;40(4):291-295.
29. Quock RL, Barros JA, Yang SW, Patel SA. Effect of silver diamine fluoride on microtensile bond strength to dentin. Oper Dent. 2012 Nov-Dec;37(6):610-6.
30. Rosenblatt A, Stamford TC, Niederman R. Silver diamine fluoride: a caries "silver- fluoride bullet". J Dent Res. 2009;88(2):116-25
31. Seifo N, Robertson M, Maclean J, Blain K, Grosse S, Milne R. The use of SDF in dental practice. Br Dent J . 2020;228(2):75–81. doi:10.1038/s41415-020-1203-9.
32. Seow WK. Early Childhood Caries. Pediatr Clin North Am. 2018 Oct;65(5):941-954. doi: 10.1016/j.pcl.2018.05.004. PMID: 30213355.
33. Thomas ML, Magher K, Mugayar L, Dávila M, Tomar SL. Silver Diamine Fluoride Helps Prevent Emergency Visits in Children with Early Childhood Caries. Pediatr Dent. 2020 May 15;42(3):217-220
34. Tjäderhane L, Nascimento FD, Breschi L, Mazzoni A, Tersariol IL, Geraldeli S, Tezvergil-Mutluay A, Carrilho MR, Carvalho RM, Tay FR, Pashley DH. Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. Dent Mater. 2013 Jan;29(1):116-35
35. Trieu A, Mohamed A, Lynch E. Silver diamine fluoride versus sodium fluoride for arresting dentine caries in children: a systematic review and meta-analysis. Sci Rep. 2019;9(1):1–9. doi:10.1038/s41598-019- 38569-9.
36. Turton B, Horn R, Durward C. Caries arrest and lesion appearance using two different silver fluoride therapies on primary teeth with and without potassium iodide: 12-month results. Clin Exp Dent Res. 2021 Aug;7(4):609-619
37. Wu DI, Velamakanni S, Denisson J, Yaman P, Boynton JR, Papagerakis P. Effect of Silver Diamine Fluoride (SDF) Application on Microtensile Bonding Strength of Dentin in Primary Teeth. Pediatr Dent. 2016 Mar-Apr;38(2):148-53.
38. Yasmi O. Crystal, Richard Niederman, Silver Diamine Fluoride Treatment Considerations in Children's Caries Management Brief Communication and Commentary, Pediatr Dent 2016;38(7):466-71
39. Yilmaz N, Ocak M, Okte Z. Remineralization of Primary Molar Dentine with Silver Diamine Fluoride and Sodium Fluoride: An In Vitro Study. Cumhuriyet Dent J 2020;23:4: 340-347.
40. Zhao IS, Gao SS, Hiraishi N, Burrow MF, Duangthip D, Mei ML, Lo EC, Chu CH. Mechanismsofsilver diamine fluoride on arresting caries: a literature review. Int Dent J. 2018 Apr;68(2):67-76.