Tumoral Calcinosis: Clinical and Radiological Findings

Abstract

Tumoral calcinosis (TC) is an infrequent hereditary ailment described by localized ectopic calcification around the joints in impacted regions. Reports of TC patients manifesting dental findings are scarce. Dental radiographs of a TC diagnosed patient revealed pulp stones, obliterated pulp cavities and short roots. In this case report, a 21-year-old female patient with TC was clinically and radiologically evaluated.

Keywords

• calcification
• calcinosis
• dental radiography
• pulp calcification
• tooth abnormalities

Tümoral Kalsinozis: Klinik ve Radyografik Bulgular

Abstract

Tümoral kalsinozis (TK), etkilenen bölgelerdeki eklemler etrafında anormal kalsifikasyonla belirgin, nadir görülen kalıtsal bir bozukluktur. TK hastalarının dental bulgularını içeren raporlar sınırlıdır. TK tanısı konmuş bir hastanın radyografisinde kısa kökler, pulpa taşları ve oblitere olmuş pulpa boşlukları belirgindir. Bu olgu sunumunda, 21 yaşındaki TK tanılı kadın hasta klinik ve radyolojik bulgular yönünden değerlendirilmiştir.

Keywords

• dental radyografi
• diş anomalileri
• kalsifikasyon
• kalsinoz
• pulpa kalsifikasyonu

References

1. Burkes EJ Jr, Lyles KW, Dolan EA, Giammara B, Hanker J. Dental lesions in tumoral calcinosis. J Oral Pathol Med. 1991;20:222–7.
2. Davies AM. Imaging of soft tissues. In: Diagnostic Radiology. A Textbook of Medical Imaging 4th ed. Grainger RG, Allison DJ, Adam A, Dixon AK (eds). London: Churchill Livingstone; 2002: p. 2080.
3. Dumitrescu CE, Kelly MH, Khosravi A, Hart TC, Brahim J, White KE, et al. A case of familial tumoral calcinosis/hyperos- tosis-hyperphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demonstrating new phenotypic features. Osteoporos Int. 2009;20:1273–8.
4. Duret MH. Tumeurs multiples et singerlaires des courses sereuses. Bull Mem Soc Anat. 1899; 74: 725–731.
5. Favia G, Lacaita MG, Limongelli L, Tempesta A, Laforgia N, Cazzolla AP, et al. Hyperphosphatemic familial tumoral calcinosis: odontostomatologica management and pathological features. Am J Case Rep. 2014;15:569–75.
6. Foster BL, Ramnitz MS, Gafni RI, Burke AB, Boyce AM, Lee JS, et al. Rare bone diseases and their dental, oral, and cranio- facial manifestations. J Dent Res. 2014;93:7S–19S.
7. Gal G, Metzker A, Garlick J, Gold Y, Calderon S, Tiqva P, Brook S. Head and neck manifestations of Tumoral Calcinosis. Oral Surg Oral Med Oral Pathol. 1994; 74: 158–166.
8. Hacihanefioglu U. Tumoral calcinosis. A clinical and pathological study of eleven unreported cases in Turkey. J Bone Joint Surg Am. 1978;60:1131-5.

9. Hammoud S, McCarthy EF, Weber K. Tumoral calcinosis in infants: a report of three cases and review of the literature. Clin Orthop Relat Res. 2005;(436):261-4.
10. Hunter OP, MacDonald DG, Ferguson MM. Development abnormalities of the dentin associated with Tumoral calcinosis. Br Dent J. 1973; 135: 446–448.
11. Ichikawa S, Imel EA, Kreiter ML, Yu X, Mackenzie DS, Sorenson AH, et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest. 2007; 117:2684–91. doi: 10.1172/JCI31330.
12. Inclan A. Tumoral Calcinosis. J Am Med Assoc. 1943; 121: 490–495.
13. Krstevska A, Gale S, Blair F. Tumoral calcinosis: a dental literature review and case report. Dent Update. 2012;39(416–8):421. 11.
14. Marinho ROM, Anderson GP, Warren AY. Tumoral calcinosis in the premaxillary region. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 87: 725–729.
15. Naikmasur V, Guttal K, Bhargava P, Burde K, Sattur A, Nandi- math K. Tumoral calcinosis with dental manifestations-a case report. Dent Update. 2008;35(134–6):138.
16. Noffke C, Raubenheimer E, Fischer E. Tumoral calcinosis of the temporomandibular joint region. Dentomaxillofac Radiol. 2000; 29: 128–130.
17. Olsen KM, Chew FS. Tumoral calcinosis: pearls, polemics, and alternative possibilities. Radiographics. 2006;26:871–85.
18. Polykandriotis EP, Beutel FK, Horch RE, Grünert J. A case of familial tumoral calcinosis in a neonate and review of the literature. Arch Orthop Trauma Surg. 2004;124:563–7.
19. Ramnitz MS, Gourh P, Goldbach-Mansky R, Wodajo F, Ichikawa S, Econs MJ, et al. Phenotypic and genotypic characterization and treatment of a cohort with familial tumoral calcinosis/hyperostosis-hyperphosphatemia syndrome. J Bone Miner Res. 2016; 31:1845–54. doi: 10.1002/jbmr.2870.
20. Shirasuna K, Sugiyama M, Yasui Y. Tumoral calcinosis around the mandibular condyle. Int J Oral Maxillofac Surg. 1991; 20: 36–37.
21. Stewart GG. Gaining access to calcified canals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 79:764–8. doi: 10.1016/S1079-2104(05)80314-2.
22. Topaz O, Shurman DL, Bergman R, Indelman M, Ratajczak P, Mizrachi M, et al. Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 2004; 36:579– 81. doi: 10.1038/ng1358.
23. Witcher SL, Drinkard DW, Shapiro RD, Schow CE. Tumoral calcinosis with unusual dental radiographic findings. Oral Surg Oral Med Oral Pathol. 1989; 68: 104–107.
24. Yamamoto H, Ramos-Molina B, Lick AN, Prideaux M, Albornoz V, Bonewald L, et al. Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition. Bone. 2016; 84:120– 30. doi: 10.1016/j.bone.2015.12.055.
25. Yilanci HO, Akkaya N, Ozbek M, Celik HH. Dental findings of hyperphosphatemic familial tumoral calcinosis. Oral Radiol. 2017; 33:65–70. doi: 10.1007/s11282-016-0237-9.
26. Yochum TR, Rowe LJ. Arthritic disorders. In: Essentials of Skeletal Radiology 3th ed. Yochum TR, Rowe LJ (eds). Philadelphia: Lippincott Williams & Wilkins, 2005: p. 1112.
27. Zanetti U, Derada Troletti G, Rossi D. Tumoral calcinosis: a case report. Int J Oral Maxillofac Surg. 1994; 23: 271–272.