COVID-19 Enfeksiyonunu Geçirmiş Sağlıklı Bireylerde Tükürük Parametreleri ve Doku Faktörünün Araştırılması

Year 2024, , 55 - 58, 29.08.2024

Şehkar Oktay , Eren Aslan , Gökçe Akyol , Saliha Kaya , Füsun Karatepe

https://doi.org/10.29228/erd.71

Abstract

Amaç: Ağız mukozası, COVID-19 enfeksiyonunun yayılması için uygun bir alandır ve tükürük bezlerinde fonksiyon bozukluklarına neden olur. Doku faktörü, tükürükte de bulunan, hemostaz ve pıhtılaşma mekanizmalarında rol oynayan önemli bir düzenleyicidir. Çalışmanın amacı, COVID-19 enfeksiyonunun tükürük bezi fonksiyonu ve ağız sağlığı üzerindeki etkilerini tükürük yoluyla incelemektir.
Gereç ve Yöntemler: Kontrol grubu daha önce COVID-19 enfeksiyonu geçirmemiş 20 kişiden oluşurken, COVID grubu ise en az 6 ay önce COVID-19 enfeksiyonu geçiren 26 kişiden oluştu. Tükürük örneklerinde tükürük akış hızı, tamponlama kapasitesi, pH ve doku faktörü aktivitesi değerlendirildi.
Bulgular: Kontrole göre COVID grubunda tükürük akış hızı, tamponlama kapasitesi ve doku faktörü aktivitesi anlamlı derecede azalırken, pH'ın gruplar arasında istatistiksel olarak anlamlı olmadığı görüldü.
Sonuçlar: COVID-19 enfeksiyonu sonrasında ağız dokularında çeşitli hasarlar ve buna bağlı fonksiyon bozuklukları gelişmektedir. Bu nedenle COVID-19 geçiren bireylerin ağız hastalıklarına eğilimi daha fazla olabilir.

Keywords

Tükürük, Akış hızı, Tamponlama kapasitesi, Doku faktörü, COVID-19

Investigation of Saliva Parameters and Tissue Factor in Healthy Individuals Who Had Survived COVID-19 Infection

Abstract

Objectives: Oral mucosa is a suitable area for the spread of COVID-19 infection and it causes dysfunction in the salivary glands. Tissue factor is an important regulator that plays a role in hemostasis and coagulation mechanisms, also found in saliva. The aim of the study is to examine the effects of COVID-19 infection on salivary gland function and oral health through saliva.
Materials and Methods: The control group consists of 20 individuals who have not had a COVID-19 infection before, while the COVID group consists of 26 individuals who had a COVID-19 infection at least 6 months ago. Salivary flow rate, buffering capacity, pH, and tissue factor activity were evaluated in saliva samples.
Results: Salivary flow rate, buffering capacity, and tissue factor activity decreased significantly in the COVID group compared to the controls, while pH was found to be statistically not significant between the groups.
Conclusions: Various damages and related dysfunctions develop in the oral tissues following a COVID-19 infection. For this reason, individuals who have had COVID-19 might have more tendency to oral diseases.

Keywords

Saliva, Flow rate, Buffering capacity, Tissue factor, COVID-19

Ethical Statement

Ethics committee approval was received from the Marmara University Health Sciences Institute Ethics Committee (protocol no:09.2022.161).

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