Peri-İmplantitis de İnterlökin 6 (rs1800795) ve Diğer Proinflamatuar Sitokin olan İnterlökinlerin Gen Polimorfizmlerinin Etkileri: Kısa bir İnceleme

Abstract

Tıp alanında değerlendirilen bir hastalık diş hekimliği alanındaki bir hastalık için prediktör olabileceği gibi diş hekimliği alanındaki bir hastalık tıp alanındaki bir hastalığın öncüsü olabilir. Bunun bir örneği bağışıklık sisteminin bir alanı olan hücresel bağışıklık faktörlerinin diş hekimliği literatürü içerisinde değerlendirilen “implant çevresi hastalıkları” ile ilişkisidir. İnsanlarda yaşam kalitesinin ve yaşam sürecinin artması ile oral rehabilitasyon sürecinde ağız ve diş sağlığına yönelik yeni tedavi metodolojilerini araştırmasını zorunlu hale getirmektedir. İmplant çevresi hastalıkları araştırılması önemli olan konulardan birisidir. İmplant tedavisinin başarısını ve etkinliğini belirleyen bireyin genetik yapısı, mikrobiyolojik ve çevresel faktörler gibi birçok etmen bulunmaktadır. İncelemesini yapmış olduğumuz peri-implantitis hastalığında bağışıklıkla ilişkili proinflamatuar sitokinlerin alt yapısını bilmek bu hastalıkla ilgili tedavi yaklaşımlarının etkinliğine katkı sağlayabilir. Bizde bu bağlamda önemli bir proinflamatuar sitokin olan IL-6 rs1800795 gen polimorfizminin ve interlökin sınıfında değerlendirilen diğer proinflamatuar sitokinlerden olan IL-1, IL-8 ve IL-17 gen polimorfizmlerinin peri-implantitis ve dolayısıyla periodontal hastalıklar üzerine etkinliğini değerlendiren çalışmalardan kısa bir derleme çalışmasını sizlere sunmayı hedefledik.

Keywords

• Peri-implantitis
• İnterlökin-6
• İnterlökinler
• Proinflamatuar sitokinler
• Genetik polimorfizm

Effects of Interleukin 6 (rs1800795) and Other Proinflammatory Interleukins Gene Polymorphisms in Periodontal Diseases: A Brief Review

Abstract

A disease evaluated in medicine can be a predictor for a disease in dentistry, and a disease in dentistry can be a precursor to a disease in medicine. An example is the relationship between cellular immune factors, which are a field of the immune system, and “peri-implant diseases” evaluated in the dentistry literature. The increase in the quality of life and life span in people necessitates the research of new treatment methodologies for oral and dental health in the oral rehabilitation process. Peri-implant diseases are one of the important issues to investigate. There are many factors such as the genetic structure of the individual, and microbiological and environmental factors that determine the success and effectiveness of implant treatment. Knowing the infrastructure of immune-related proinflammatory cytokines in the peri-implantitis disease that we have examined can contribute to the effectiveness of treatment approaches related to this disease. In this context, we aimed to present a brief review of studies evaluating the effectiveness of the IL-6 rs1800795 gene polymorphism, an important proinflammatory cytokine, and the IL-1, IL-8 and IL-17 gene polymorphisms, which are other proinflammatory cytokines evaluated in the interleukin class, on peri-implantitis and therefore periodontal diseases.

Keywords

• Peri-implantitis
• Interleukin-6
• Gene polymorphism
• Interleukins
• Proinflammatory cytokines

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