Lipids and Their Importance in Dentistry

Year 2020, , 89 - 93, 31.12.2020

Özge Çibuk , Ayşen Yarat

https://doi.org/10.35333/ERD.2020.272

Abstract

Lipids in the structure of cell membranes in the oral environment determine the elasticity, fluidity and permeability of the cell membrane and participate in intercellular transport and signal transduction pathways between the salivary glands and other tissues. Lipids are also important main components of saliva. The properties and number of lipid component in cells and tissues vary according to various physiological and pathological conditions. Identification of lipids, which play a major role in disease states, is used to evaluate the diagnosis and treatment response of diseases. This also applies to various oral diseases. For example, in the presence of chronic periodontititis, caries and calculus, the amount of lipids in saliva increases. Oral surface lipids of pathogenic bacteria such as Porhynomonas gingivalis, one of the main bacteria causing periodontitis, also cause negative effects.

Keywords

lipids, saliva, oral health

References

• 1-Alturfan EI. Lipidlerin yapısı. Bölüm 11. Biyokimyada Temel ve Özel Konular, Editörler, Prof. Dr. Ayşen Yarat, Prof.Dr. Tuğba Tunalı Akbay, Prof. Dr. Ebru Işık Alturfan, pp: 139-155, 2019
• 2-Slomiany BL, Witas H, Murty VL, Slomiany A,Mandel ID. Association of lipids with proteins and glycoproteins in human saliva. J Dent Res; 62:24-7. 1983.
• 3-Murty VL, Slomiany BL, Laszewicz W, Slomiany A, Petropoulou K, Mandel ID. Lipids of developing dental plaque in caries-resistant and caries-susceptible adult people. Arch Oral Biol; 30(2):171-5. 1985.
• 4- Matczuk J, Piotrowska M, Maciejczyk M, Kurek K. Salivary Lipids: A Review. Adv Clin Exp Med 2017; 1021-1029
• 5-Slomiany BL, Murty VL, Slomiany A. Salivary lipids in health and disease. Prog Lipid Res; 24: 311-24. 1985.
• 6- Fernandis AZ and Wenk MR, “Membrane lipids as signaling molecules,” Curr Opin Lipidol. vol. 18, no. 2, pp. 121–128, 2007.
• 7- Quehenberger O, Armando AM, Brown AH et al., “Lipidomics reveals a remarkable diversity of lipids in human plasma,” J. Lipid Res. vol. 51, no. 11, pp. 3299– 3305, 2010
• 8- Bligh EG and Dyer WJ, “A rapid method of total lipid extraction and purification,” "Can J Biochem. vol. 37, no. 8, pp. 911–917, 1959.
• 9- Schweigel H, Wicht M, Schwendicke F. Salivary and pellicle proteome: A datamining analysis. Sci Rep. 2016 14;6: 38882. doi: 10.1038/srep38882.
• 10- Hannig M, Hannig C. The pellicle and erosion. Monogr Oral Sci 2014;25:206-14.doi:10.1159/000360376
• 11- Slomiany BL, Murty VLN, Mandel ID, Sengupta S, Slomiany A. Effect of Lipids on the Lactic Acid Retardation Capacity of Tooth Enamel and Cementum Pellicles Formed in Vitro from Saliva of Caries-Resistant and Caries Susceptible Human Adults. Arch Oral Biol 1990; 35: 175-80
• 12- Slomiany BL, Murty VLN, Aono M, Slomiany A, Mandel ID. Lipid Composition of Human Parotid and Submandibular Saliva from Caries-Resistant and Caries-Susceptible Adults. Arch Oral Biol 1982; 27: 803-8
• 13- Cajka T and Fiehn O, “Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry,” Trends Anal Chem. vol. 61, pp. 192– 206, 2014
• 14- Zaura E, Twetman S. Critical Appraisal of Oral Pre- and Probiotics for Caries Prevention and Care. Caries Res 2019;53(5):514-526. doi: 10.1159/000499037.
• 15- Shama A, Sindhuja M, Subramaniam P. Association of Salivary Lipids and Early Childhood caries in an Indian Subpopulation. J Clin Pediatr Dent. 2019; 43: 393-397.
• 16- Evans E, Hoyes C, Carole A, Palmer O, Steven A, Cohen D. Dietary Intake and Severe Early Childhood Caries in Low-Income, Young Children. J Acad Nutr Diet. 2013; 113(8): 1057-610
• 17- Kalsbek H, Verrips GH. Consumption of Sweet Snacks and Caries Experience of Primary School Children. Caries Res. 1994; 28:477-83.
• 18- Kaewkamnerdpong I, Krisdapong S. The Associations of School Oral Health-Related Environments with Oral Health Behaviours and Dental Caries in Children. Caries Res 2018;52(1-2):166-175 doi: 10.1159/000485747. Epub 2018 Jan 23.
• 19- Thomas B, Rajendra B, Prasad, Shetty S, Vishakh R. Comparative Evaulation of the
• Lipid Profile in the Serum of Patients with Type 2 Diabetes Mellitus and Healthy Individuals
• with Periodontitis. Contemp Clin Dent. 2017; 8:96-101
• 20- Mealey BL, Oates TW; American Academy of Periodontology. Diabetes Mellitus and Periodontal Diseases. J Periodontol. 2006; 77:1289‑303
• 21- Curzon ME. Preventive dentistry: Early childhood caries in infants. Br Dent J 2015 Apr 24;218(8):438-9. doi: 10.1038/sj.bdj.2015.300.
• 22- Kensche A, Reich M, Hannig C. Lipids in Preventive Dentistry. Clin Oral Invest. 2013; 17:669-685
• 23- Azizi F, Rahmani M, Ghanbarian A, Emami H, Salehi P, Mirmiran P, et al. Serum lipid levels in an Iranian adults population: Tehran Lipid and Glucose Study. Eur J Epidemiol. 2003;18(4):311–9
• 24- Satterlee AB, and Huang L. Current and Future theranostic Applications of the Lipid-Calcium-Phosphate Nanoparticle Platform. Theranostics. 2016; 6, 918–929. doi: 10.7150/thno.14689
• 25- Zhi D, Bai Y, Yang J, Cui S, Zhao Y, Chen H, et al. A Review Oncationic Lipids with Different Linkers for Gene Delivery. ‎Adv Colloid Interface Sci 2018; 253, 117–140
• 26-Williams DE, and Grant KB. Metal-Assisted Hydrolysis Reactions Involving Lipids: a Review. Front Chem. 2019; 7:14
• 27- Alexis F, Pridgen E, Molnar LK, and Farokhzad OC. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles. Mol Pharm. 2008; 5,505–515.
• 28-Nuti S, Fernández-Lodeiro J, Del Secco B, Rampazzo E, Rodríguez-González B, Capelo JL, et al. Engineered Nanostructured Materials for ofloxac in delivery. Front Chem. 2018; 6:554.
• 29- Zhu N, Chatzistavrou X, Ge L, Qin M, Papagerakis P, and Wang Y. Biological Properties of Modified Bioactive Glass on Dental Pulp Cells. J Dent. 2019; 83: 18–26.
• 30- Reich M, Kümmerer K, Al-Ahmad A, Hannig C. Fatty acid profile of the initial oral biofilm (pellicle): an in-situ study. Lipids 2013; 48: 929- 37.
• 31- Olsen I, Nichols FC. Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porhynomonas Gingivalis. Infect Immun. 2018; 86:1-10
• 32- Tsuda K, Amano A, Umebayashi K, Inaba H, Nakagawa I, Nakanishi Y, Yashimori T. Molecular Dissection of Internalization of Porhynomonas Gingivalis Cells Using Fluorescent Beads Coated with Bacterial Membrane Vesicle. Cell Struct Funct. 2005; 30:81-91
• 33-Tsuda K, Furuta N, Inaba H, Kawai S, Hanada K, Yashimori T, Amano A. Functional Analysis of Alpha5betal Integrin and Lipid Rafts in Invasion of Epithelial Cells by Porhynomonas Gingivalis Using Fluorescent Beads Coated with Bacterial Membrane Vesicles. Cell Struct Funct. 2008; 33:123-132.
• 34- Olsen I, Nichols FC. Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porhynomonas Gingivalis. Infect Immun. 2018; 86:1-10
• 35- Oksuz G, Urfalioglu A, Sekmen T, Akkececi N, Alpay N, Bilal B. Dentists Knowledge of Lipid Treatment of Local Anaesthetic Systemic Toxicity. Niger J Clin Pract 2018; 21-3: 327-331
• 36- Jensen Gadegaard P, Skjønnemand M, Damgaard Jensen J, Gottschau B. Limited knowledge of lipid rescue therapy in local anaesthetic systemic toxicity. Dan Med Bull 2011;58:A4226.
• 37- Basaranoglu G, Teker MG, Saidoglu L, Muhammedoglu N, Ozdemir H. The Knowledge of the Physicians who Use Local Anaesthetics About Their Toxicity and Intralipid Therapy. Turk J Anaesthesiol Reanim 2010;38:262 7