Research Article
BibTex RIS Cite

Lokal Anesteziklerin Sistemik Toksisitesi: Ebelerin Farkındalık ve Bilgi Yeterliliğinin Değerlendirilmesi

Year 2026, Volume: 9 Issue: 1 , 65 - 72 , 30.03.2026
https://doi.org/10.62425/esbder.1814664
https://izlik.org/JA23WE72KE

Abstract

Amaç: Çalışmamızın temel amacı, ebelerin sık kullanılan lokal anesteziklerle bağlantılı sistemik toksisite konusundaki anlayış ve bilgilerini değerlendirmektir. Gereç ve Yöntemler: Çalışma, Türkiye genelindeki çeşitli hastanelerde çalışan 181 ebeyi kapsamaktadır. Veri toplama aracı olarak bir anket kullanılmıştır. Elde edilen veriler IBM SPSS Statistics 25.0 for Windows ile istatistiksel olarak değerlendirilmiştir. Bulgular: Lokal anestezik sistemik toksisitesinin tedavisine yanıt olarak, katılımcıların %16,6'sı lokal anestezik uygulamasının durdurulmasını, %66,9'u oksijen uygulaması ve hava yolu yönetimini ve %16,6'sı %20'lik lipit solüsyonu uygulanmasını önermiştir. Katılımcıların erken dönem semptomlarının farkındalığının değerlendirilmesinde, sadece "dengesizlik" semptomunda istatistiksel olarak anlamlı bir değişim gözlenmiştir. Geç dönem semptomlarının farkındalığı ve mesleki deneyimleri değerlendirildiğinde ise, yalnızca solunum depresyonu ile ilgili yanıtlar istatistiksel olarak anlamlı bulunmuştur. Sonuç: Bulgularımız, ebelerin lokal anestezik sistemik toksisitesinin semptomatolojisi, önlenmesi ve yönetimi konusunda farkındalıklarını ve anlayışlarını artırmak için eğitime ihtiyaç duyduklarını göstermektedir.

References

  • Aydin, P. (2022). Local anesthetic systemic toxicity: Evaluation of awareness and knowledge levels of anesthesia technicians.
  • Becker, D. E., & Reed, K. L. (2012). Local anesthetics: review of pharmacological considerations. Anesthesia Progress, 59(2), 90-101; quiz 102-103. https://doi.org/10.2344/0003-3006-59.2.90
  • Beckmann, T. S., Samer, C. F., Wozniak, H., Savoldelli, G. L., & Suppan, M. (2024). Local anaesthetics risks perception: A web-based survey. Heliyon, 10(1), e23545. https://doi.org/10.1016/j.heliyon.2023.e23545
  • Bern, S., & Weinberg, G. (2011). Local anesthetic toxicity and lipid resuscitation in pregnancy. Current Opinion in Anesthesiology, 24(3), 262-267. https://doi.org/10.1097/ACO.0b013e32834654df
  • De Valle, M. K., Adkison, M., Maredia, R., Stevenson, C., & Murugan, S. (2024). Local Anesthetic Systemic Toxicity in Pregnancy: A Retrospective Cohort Analysis. Cureus, 16(9), e69215. https://doi.org/10.7759/cureus.69215
  • Di Gregorio, G., Neal, J. M., Rosenquist, R. W., & Weinberg, G. L. (2010). Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Regional Anesthesia & Pain Medicine, 35(2), 181-187. https://doi.org/10.1097/aap.0b013e3181d2310b
  • Dickerson, D. M., & Apfelbaum, J. L. (2014). Local anesthetic systemic toxicity. Aesthetic Surgery Journal, 34(7), 1111-1119. https://doi.org/10.1177/1090820x14543102
  • Drasner, K. (2010). Local anesthetic systemic toxicity: a historical perspective. Regional Anesthesia & Pain Medicine, 35(2), 162-166. https://doi.org/10.1097/AAP.0b013e3181d2306c
  • El-Boghdadly, K., Pawa, A., & Chin, K. J. (2018). Local anesthetic systemic toxicity: current perspectives. Local and Regional Anesthesia, 11, 35-44. https://doi.org/10.2147/lra.s154512
  • Ferry, S. L., & Cook, K. R. (2020). Local Anesthetic Systemic Toxicity (LAST): Increasing Awareness Through Education. Journal of PeriAnesthesia Nursing, 35(4), 365-367. https://doi.org/10.1016/j.jopan.2020.02.013
  • Gitman, M., Fettiplace, M. R., Weinberg, G. L., Neal, J. M., & Barrington, M. J. (2019). Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis, and Management. Plastic and Reconstructive Surgery, 144(3), 783-795. https://doi.org/10.1097/prs.0000000000005989 https://www.resmigazete.gov.tr/eskiler/2024/12/20241203-2.htm. (2024).
  • Mahajan, A., Song, K., & Derian, A. (2025). Local Anesthetic Toxicity. In StatPearls. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.
  • Mock, N. D., Griggs, K. M., & Mileto, L. A. (2021). Local Anesthetic Systemic Toxicity during Labor, Birth, and Immediate Postpartum: Clinical Review. MCN: The American Journal of Maternal/Child Nursing, 46(6), 330-338. https://doi.org/10.1097/nmc.0000000000000765
  • Neal, J. M., Barrington, M. J., Fettiplace, M. R., Gitman, M., Memtsoudis, S. G., Mörwald, E. E., Rubin, D. S., & Weinberg, G. (2018). The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017. Regional Anesthesia & Pain Medicine, 43(2), 113-123. https://doi.org/10.1097/aap.0000000000000720
  • Neal, J. M., Neal, E. J., & Weinberg, G. L. (2021). American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version. Regional Anesthesia & Pain Medicine 46(1), 81-82. https://doi.org/10.1136/rapm-2020-101986
  • Ramesh, P., Demertzi, M., & Suraweera, P. (2022). Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology. Journal of Obstetrics and Gynaecology, 42(3), 505-508. https://doi.org/10.1080/01443615.2021.1916812
  • Sagir, A., & Goyal, R. (2015). An assessment of the awareness of local anesthetic systemic toxicity among multi-specialty postgraduate residents. Journal of Anesthesia, 29(2), 299-302. https://doi.org/10.1007/s00540-014-1904-9
  • Yılmaz Esencan, T., & Daştan, K. ( 2023). Doğum Eylemine Yönelik Girişimlerde Ebelerin Rolü. Kırşehir Ahi Evran Üniversitesi Sağlık Bilimleri Dergisi, 7(2), 126-135.

Systemic Toxicity of Local Anesthetics: Assessment of Midwives' Awareness and Knowledge Proficiency

Year 2026, Volume: 9 Issue: 1 , 65 - 72 , 30.03.2026
https://doi.org/10.62425/esbder.1814664
https://izlik.org/JA23WE72KE

Abstract

Aim: The main aim of our study was to assess midwives' comprehension and knowledge regarding the systemic toxicity linked to frequently utilized local anesthetics. Materials and Methods: The study comprised 181 midwives employed in various hospitals throughout Turkey. A survey served as the instrument for data gathering. The acquired data were statistically evaluated with IBM SPSS Statistics 25.0 for Windows. Results: In response to treatment of local anesthetic systemic toxicity, 16.6% of participants recommended ceasing local anesthetic administration, 66.9% advocated for oxygen administration and airway management, and 16.6% suggested the administration of a 20% lipid solution. A statistically significant shift was noted just for the symptom of "imbalance" in the evaluation of participants' awareness of early-stage symptoms. Upon evaluating their awareness of late-stage symptoms and professional experience, only the responses pertaining to respiratory depression demonstrated statistical significance. Conclusion: Our findings indicate that midwives require training to enhance their awareness and understanding of the symptomatology, prevention, and management of local anesthetic systemic toxicity.

References

  • Aydin, P. (2022). Local anesthetic systemic toxicity: Evaluation of awareness and knowledge levels of anesthesia technicians.
  • Becker, D. E., & Reed, K. L. (2012). Local anesthetics: review of pharmacological considerations. Anesthesia Progress, 59(2), 90-101; quiz 102-103. https://doi.org/10.2344/0003-3006-59.2.90
  • Beckmann, T. S., Samer, C. F., Wozniak, H., Savoldelli, G. L., & Suppan, M. (2024). Local anaesthetics risks perception: A web-based survey. Heliyon, 10(1), e23545. https://doi.org/10.1016/j.heliyon.2023.e23545
  • Bern, S., & Weinberg, G. (2011). Local anesthetic toxicity and lipid resuscitation in pregnancy. Current Opinion in Anesthesiology, 24(3), 262-267. https://doi.org/10.1097/ACO.0b013e32834654df
  • De Valle, M. K., Adkison, M., Maredia, R., Stevenson, C., & Murugan, S. (2024). Local Anesthetic Systemic Toxicity in Pregnancy: A Retrospective Cohort Analysis. Cureus, 16(9), e69215. https://doi.org/10.7759/cureus.69215
  • Di Gregorio, G., Neal, J. M., Rosenquist, R. W., & Weinberg, G. L. (2010). Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Regional Anesthesia & Pain Medicine, 35(2), 181-187. https://doi.org/10.1097/aap.0b013e3181d2310b
  • Dickerson, D. M., & Apfelbaum, J. L. (2014). Local anesthetic systemic toxicity. Aesthetic Surgery Journal, 34(7), 1111-1119. https://doi.org/10.1177/1090820x14543102
  • Drasner, K. (2010). Local anesthetic systemic toxicity: a historical perspective. Regional Anesthesia & Pain Medicine, 35(2), 162-166. https://doi.org/10.1097/AAP.0b013e3181d2306c
  • El-Boghdadly, K., Pawa, A., & Chin, K. J. (2018). Local anesthetic systemic toxicity: current perspectives. Local and Regional Anesthesia, 11, 35-44. https://doi.org/10.2147/lra.s154512
  • Ferry, S. L., & Cook, K. R. (2020). Local Anesthetic Systemic Toxicity (LAST): Increasing Awareness Through Education. Journal of PeriAnesthesia Nursing, 35(4), 365-367. https://doi.org/10.1016/j.jopan.2020.02.013
  • Gitman, M., Fettiplace, M. R., Weinberg, G. L., Neal, J. M., & Barrington, M. J. (2019). Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis, and Management. Plastic and Reconstructive Surgery, 144(3), 783-795. https://doi.org/10.1097/prs.0000000000005989 https://www.resmigazete.gov.tr/eskiler/2024/12/20241203-2.htm. (2024).
  • Mahajan, A., Song, K., & Derian, A. (2025). Local Anesthetic Toxicity. In StatPearls. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.
  • Mock, N. D., Griggs, K. M., & Mileto, L. A. (2021). Local Anesthetic Systemic Toxicity during Labor, Birth, and Immediate Postpartum: Clinical Review. MCN: The American Journal of Maternal/Child Nursing, 46(6), 330-338. https://doi.org/10.1097/nmc.0000000000000765
  • Neal, J. M., Barrington, M. J., Fettiplace, M. R., Gitman, M., Memtsoudis, S. G., Mörwald, E. E., Rubin, D. S., & Weinberg, G. (2018). The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017. Regional Anesthesia & Pain Medicine, 43(2), 113-123. https://doi.org/10.1097/aap.0000000000000720
  • Neal, J. M., Neal, E. J., & Weinberg, G. L. (2021). American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version. Regional Anesthesia & Pain Medicine 46(1), 81-82. https://doi.org/10.1136/rapm-2020-101986
  • Ramesh, P., Demertzi, M., & Suraweera, P. (2022). Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology. Journal of Obstetrics and Gynaecology, 42(3), 505-508. https://doi.org/10.1080/01443615.2021.1916812
  • Sagir, A., & Goyal, R. (2015). An assessment of the awareness of local anesthetic systemic toxicity among multi-specialty postgraduate residents. Journal of Anesthesia, 29(2), 299-302. https://doi.org/10.1007/s00540-014-1904-9
  • Yılmaz Esencan, T., & Daştan, K. ( 2023). Doğum Eylemine Yönelik Girişimlerde Ebelerin Rolü. Kırşehir Ahi Evran Üniversitesi Sağlık Bilimleri Dergisi, 7(2), 126-135.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Ömer Doymuş 0000-0002-4377-4490

Pelin Aydın 0000-0001-7279-7758

Submission Date October 31, 2025
Acceptance Date March 11, 2026
Publication Date March 30, 2026
DOI https://doi.org/10.62425/esbder.1814664
IZ https://izlik.org/JA23WE72KE
Published in Issue Year 2026 Volume: 9 Issue: 1

Cite

APA Doymuş, Ö., & Aydın, P. (2026). Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency. Journal of Midwifery and Health Sciences, 9(1), 65-72. https://doi.org/10.62425/esbder.1814664
AMA 1.Doymuş Ö, Aydın P. Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency. Journal of Midwifery and Health Sciences. 2026;9(1):65-72. doi:10.62425/esbder.1814664
Chicago Doymuş, Ömer, and Pelin Aydın. 2026. “Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency”. Journal of Midwifery and Health Sciences 9 (1): 65-72. https://doi.org/10.62425/esbder.1814664.
EndNote Doymuş Ö, Aydın P (March 1, 2026) Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency. Journal of Midwifery and Health Sciences 9 1 65–72.
IEEE [1]Ö. Doymuş and P. Aydın, “Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency”, Journal of Midwifery and Health Sciences, vol. 9, no. 1, pp. 65–72, Mar. 2026, doi: 10.62425/esbder.1814664.
ISNAD Doymuş, Ömer - Aydın, Pelin. “Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency”. Journal of Midwifery and Health Sciences 9/1 (March 1, 2026): 65-72. https://doi.org/10.62425/esbder.1814664.
JAMA 1.Doymuş Ö, Aydın P. Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency. Journal of Midwifery and Health Sciences. 2026;9:65–72.
MLA Doymuş, Ömer, and Pelin Aydın. “Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency”. Journal of Midwifery and Health Sciences, vol. 9, no. 1, Mar. 2026, pp. 65-72, doi:10.62425/esbder.1814664.
Vancouver 1.Ömer Doymuş, Pelin Aydın. Systemic Toxicity of Local Anesthetics: Assessment of Midwives’ Awareness and Knowledge Proficiency. Journal of Midwifery and Health Sciences. 2026 Mar. 1;9(1):65-72. doi:10.62425/esbder.1814664

Content of this journal is licensed under a Creative Commons Attribution NonCommercial 4.0 International License

2992931409