Serebral Venöz Trombozunda Çoklu Risk Faktörü: Olgu Sunumu

Year 2020, Volume: 1 Issue: 1, 14 - 17, 02.11.2020

Zeynep Özözen Ayas Gülgün Uncu

https://doi.org/10.48176/esmj.2020.4

Abstract

Serebral venöz tromboz (SVT) genç erişkinlerde görülen önemli bir inme nedenidir. SVT geniş klinik bulgulara sahiptir. Hastalık kalıtımsal ve kazanılmış risk faktörleri ile ilişkilidir. SVT ç n bel rg n b r r sk faktörü varlığında b le genet k trombot k faktörler n her hastada s stemat k olarak araştırılması gerekl d r. Hastalığın neden tedav ed lerek genellikle komplikasyonlar ve rekürrens önlenebilir. Bu yazıda postpartum dönemde SVT tanısı alan demir eksikliği anemisi, akut sinüzit ve MTHFR c.C677T heterozigot ve PAI-1 4G/4G homozigot mutasyonları saptanan 32 yaşındaki kadın hasta sunulmuştur.

Keywords

Serebral venöz tromboz, postpartum, çoklu risk faktörü

Multiple Risk Factors for Cerebral Venous Thrombosis: A Case Report

Abstract

Cerebral venous thrombosis (CVT) is an important cause of stroke in young adults. CVT has a wide clinical presentation. It may be associated with inherited and acquired risks factors. Even in the presence of a marked risk factor, genetic thrombotic factors should be systematically investigated. Correcting the cause of CVT, generally the complications and recurrence can be prevented. In this article, we report a 32-year-old woman with cerebral venous thrombosis who was diagnosed with iron deficiency anemia, acute sinusitis, and MTHFR c.C677T heterozygote and PAI-1 4G/4G homozygote mutation during postpartum period.

Keywords

Cerebral venous thrombosis, postpartum, multiple risk factors

References

• 1. Coutinho JM, Zuurbier SM, Aramideh M, et al. The incidence of cerebral venous thrombosis: a cross-sectional study. Stroke. 2012;43:3375-3377.
• 2. Bousser MG, Ferro JM. Cerebral venous thrombosis: An update. Lancet Neurology. 2007;6:162-170.
• 3. Star M, Flaster M. Advances and controversies in the management of cerebral venous thrombosis. Neurologic Clinics. 2013;31:765-783
• 4. Ferro JM, Canhao P, Stam J, et al; ISCVT investigators. Prognosis of Cerebral Vein and Dural Sinus Thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35:664-70.
• 5. Agostoni E, Aliprandi A, Longoni M. Cerebral venous thrombosis. Expert Rev Neurother. 2009;9:553-64.
• 6. Martinelli I, De Stefano V, Taioli E, et al. Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. Thromb Haemost. 2002;87:791-5.
• 7. Mc Coll MD, Walker ID, Greer IA. The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. Br J Obstet Gynaecol. 1999;106:756-66.
• 8. Agostoni E, Aliprandi A, Longoni M. Cerebral venous thrombosis. Expert Rev Neurother. 2009 Apr;9(4):553-64.
• 9. Kim JS, Kang SY. Bleeding and subsequent anemia: a precipitant for cerebral infarction. Eur Neurol. 2000;43(4):201-8.
• 10. Stolz E, Valdueza JM, Grebe M, et al. Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Results of a prospective study. J Neurol. 2007;254:729-34.
• 11. Sazci A, Ergul E, Kaya G, et al. Genotype and allele frequencies of the polymorphic Methylenetetrahydrofolate Reductase gene in Turkey. Cell Biochem Funct. 2003;23:51-4.