Ailesel Akdeniz Ateşi ve Multipl Skleroz Birlikteliği: Olgu Sunumu

Year 2020, Volume: 1 Issue: 1, 22 - 25, 02.11.2020

Duygu Arslan Mehdiyev , Egemen İdiman

https://doi.org/10.48176/esmj.2020.6

Abstract

Ailevi Akdeniz Ateşi (FMF) etnik kökenli, tekrarlayan akut ateş ve seröz zarların iltihabı ile karakterize, otozomal resesif geçişli, genetik bir hastalıktır. Multipl skleroz (MS) multifaktöryel etyolojiye sahip santral sinir sisteminin enflamatuar demiyelinizan bir hastalığıdır. FMF seyrinde santral sinir sistemi tutulumu sık görülen bir durum değildir. FMF’in multipl skleroz ile ilişkisi olduğunu savunan görüşler yanı sıra bunun rastlantısal bir birliktelik olduğunu iddia eden görüşler de bulunmaktadır. Bu yazıda FMF tanılı bir hastada multipl skleroz tanısı koyulma süreci paylaşılmıştır.

Keywords

Multipl skleroz, Ailesel Akdeniz Ateşi, MEFV, Pyrin

Coexistence of Familial Mediterranean Fever and Multiple Sclerosis: A Case Report

Abstract

Familial Mediterranean Fever (FMF) is an autosomal recessively inherited genetic disease of ethnic origin, characterized by recurrent acute fever and inflammation of the serous membranes. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with a multifactorial etiology. Central nervous system involvement is not common in the course of FMF. There are opinions arguing that FMF is related to multiple sclerosis as well as claiming that it is a coincidental association. In this article, the process of diagnosing multiple sclerosis in a patient with FMF is shared.

Keywords

Multiple sclerosis, Familial Mediterranean Fever, MEFV, Pyrin

References

• 1. Ugurlu S, Bolayir E, Candan F, et al. Familial mediterranean fever and multiple sclerosis--a case report. Acta Reumatol Port. 2009 Jan-Mar;34(1):117-9.
• 2. Alpayci M, Bozan N, Erdem S, et al. The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever. Med Hypotheses. 2012 Jun;78(6):717-20.
• 3. Yigit S, Karakus N, Kurt SG, et al. Association of missense mutations of Mediterranean fever (MEFV) gene with multiple sclerosis in Turkish population. J Mol Neurosci. 2013 Jun;50(2):275-9.
• 4. Yahalom G, Kivity S, Lidar M, et al. Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts. Eur J Neurol. 2011 Sep;18(9):1146-50.
• 5. Shinar Y, Livneh A, Villa Y, et al. Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients. Genes Immun. 2003 Apr;4(3):197-203.
• 6. Unal A, Dursun A, Emre U, et al. Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: is it a susceptibility gene? J Neurol Sci. 2010 Jul 15;294(1-2):38-42.
• 7. Zahednasab H, Esmaeili A, Bahreini SA. Is there any association between multiple sclerosis and familial Mediterranean fever? Eur J Neurol. 2011 Aug;18(8):e96; author reply e97.
• 8. Zahednasab H, Saadatnia M, Jabalameli MR, Bahreini SA. The role of MEFV gene mutations in Multiple Sclerosis susceptibility. J Neurol Sci. 2010 Nov 15;298(1-2):163; author reply 163-4.