Evaluation of factors affecting overall survival in patients with gastric adenocarcinoma - Single center experience

Year 2022, Volume: 3 Issue: 3, 297 - 302, 30.11.2022

Anıl Can Coşkun , Zeynep Gök Sargın , Güray Ceylan

https://doi.org/10.48176/esmj.2022.89

Abstract

Background: Gastric cancer is the fifth most frequently diagnosed malignancy worldwide and has a high mortality rate because it is often at an advanced stage at the time of diagnosis. We aimed to investigate the overall survival (OS) outcomes and prognostic factors associated with survival in gastric cancer patients followed-up in our center.

Methods: The data of 200 patients with gastric adenocarcinoma followed between January 2013 and September 2020 were evaluated retrospectively.

Results: The male/female ratio of the cases was 2.3:1, and the median age was 63,83± 11,88 years. It was observed that 7% of the patients were stage 1, 12.5% were stage 2, 23% were stage 3, and 55.5% were stage 4. Age (≤60 and >60), gender, tumor histological subtype, tumor size (≤5 and >5 cm), tumor location (antrum, corpus, cardia), TNM stage (1, 2, 3, or 4), lymphovascular invasion(present or absent), perineural invasion (present or absent), history of surgery (operated, inoperable), surgical margin status (positive or negative), presence of progression (present or absent) and presence of metastases (present or absent) were investigated as prognostic factors that may affect the OS. According to the univariate analysis of factors, early TNM stage, absence of metastases, adjuvant CRT, and FUFA regimen were associated with improved OS (p=0.001). Only, early T stage [OR: 1.38 (95% CI, 1.046-1,822)], (p=0.023) and adjuvant CT [OR: 4.5 (95% CI, 1.554-13.046)], (p=0.006) were related with increased OS in the multivariate logistic regression analysis of prognostic factors.

Conclusions: TNM stage, adjuvant CRT, chemotherapy regimen, and curative surgical resection significantly affected OS in patients with gastric adenocarcinoma.

Keywords

Gastric adenocancer, Chemoradiotherapy, Overall survival, TNM Staging

Mide adenokarsinomlu hastalarda genel sağkalımı etkileyen faktörlerin değerlendirilmesi - Tek merkez deneyimi

Abstract

Giriş: Mide kanseri, dünya çapında en sık teşhis edilen beşinci malignite olup, tanı anında sıklıkla ileri evrede olması nedeniyle mortalitesi yüksektir. Bu çalışmada merkezimizde takip ve tedavi edilen mide kanseri hastalarında genel sağkalım (GS) sonuçlarını ve sağ kalım ile ilişkili prognostik faktörleri araştırmayı amaçladık.

Yöntemler: Ocak 2013 - Eylül 2020 yılları arasında takip edilen mide adenokanseri olan 200 hastanın verileri retrospektif olarak değerlendirilip kaydedildi.

Bulgular: Çalışmaya alınan hastaların erkek/kadın oranı 2.3:1 ve ortanca yaş 63,83± 11,88 yıl olarak tespit edildi. Hastaların %7'sinin evre 1, %12,5'inin evre 2, %23'ünün evre 3 ve %55,5'inin evre 4 olduğu izlendi. Yaş (≤60 ve >60), cinsiyet, tümör histolojik alt tipi, tümör boyutu (≤) 5 ve >5 cm), tümör yerleşimi (antrum, korpus, kardia), TNM evresi (1, 2, 3 veya 4), lenfovasküler invazyon (var veya yok), perinöral invazyon (var veya yok), operasyon öyküsü (opere, inoperabl), cerrahi sınır durumu (pozitif veya negatif), progresyon varlığı (var veya yok) ve metastaz varlığı (var veya yok) GS'yi etkileyebilecek prognostik faktörler olarak araştırıldı. Faktörlerin tek değişkenli analizine göre; erken TNM evresi, metastaz yokluğu, adjuvan KRT ve FUFA rejimi almak, artmış GS ile ilişkiliydi (p=0.001). Sadece erken T evresi [OR: 1.38 (%95 CI, 1.046 1.822)], (p=0.023) ve adjuvan KT almak [OR: 4.5 (%95 CI, 1.554-13.046)], (p=0.006) prognostik faktörlerin çok değişkenli lojistik regresyon analizinde artan GS ile ilişkiliydi.

Sonuç: Mide adenokarsinomlu hastalarda TNM evresi, adjuvan KRT, kemoterapi rejimi ve küratif cerrahi rezeksiyon GS'yi önemli ölçüde etkiledi.

Keywords

Mide adenokanseri, Kemoradyoterapi, Genel sağkalım, TNM Evrelemesi

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