SPESİFİK OLMAYAN OKSİDATIF BİR BELİRTEÇ OLAN GAMA-GLUTAMİL TRANSFERAZ SEVİYESİ HİS-VENTRİKÜLER ARALIĞI UZAMASI İLE BAĞIMSIZ İLİŞKİLİDİR

Year 2023, Volume: 4 Issue: 1, 17 - 22, 29.03.2023

Ali Gökhan Özyıldız , Afag Özyıldız , Mustafa Çetin

https://doi.org/10.48176/esmj.2023.98

Abstract

Giriş: His-ventrikül (H-V) aralığı, His-Purkinje sistemi iletim süresini yansıtır ve elektrofizyolojik çalışmanın (EPS) temel ölçümlerinden biridir. H-V süresi uzamasında fibrozis ve yağ infiltrasyonu rol oynar. Son çalışmalar, iletim sistemindeki fibrozisin oksidatif stres tarafından tetiklenebileceğini iddia etmektedir. Gama-glutamil transferaz (GGT), oksidatif stresin spesifik olmayan bir belirtecidir ve klinikte pratik olarak değerlendirilebilir. Çalışma, H-V interval uzaması ile GGT düzeyi arasındaki ilişkiyi araştırmayı amaçlamıştır.
Yöntemler: Çalışmaya supraventriküler taşikardi tanısı ile klinik olarak endike EPS uygulanan ardışık 94 hasta (58 kadın) dahil edildi. İşlem öncesi rutin laboratuvar tetkikleri ve gama-glutamil transferaz düzeyi ölçüldü. Hastalara standart EPS protokolü uygulanarak Atriyal- His, H-V süreleri ve bazal siklus uzunluğu ölçüldü.
Bulgular: Hastaların yaş ortalaması 47.9±15.8 yıl idi. Katılımcılar H-V süresine göre ≤ 55 ms (n=66) ve >55 ms (n=28) olmak üzere iki grupta analiz edildi. Çok değişkenli lojistik regresyon analizinde
vücut kitle indeksi (VKİ) (OR 1,153, %95 CI 1,029-1,292, p=0,014) ve GGT seviyeleri (OR 1,060, %95 CI 1,013-1,108, p=0,012) H-V süresi uzaması ile bağımsız ilişkiliydi.
Sonuç: Gama-glutamil transferaz düzeyi ve VKİ H-V süresi uzamasıyla bağımsız olarak ilişkilidir. Kapsamlı çalışmalarla doğrulanması gereken GGT ve H-V süresi ilişkisi, infra-His iletim kusuru olan hastaların takibinde pratik bir yardımcı olabilir.

Keywords

Gama-glutamil transferaz, His-ventrikül süresi, Oksidatif stres

LEVEL OF GAMMA-GLUTAMYL TRANSFERASE - A NONSPECIFIC OXIDATIVE MARKER - IS INDEPENDENTLY ASSOCIATED WITH HIS-VENTRICULAR INTERVAL PROLONGATION

Abstract

Introduction: His-ventricle (H-V) interval is one of the basic measurements of the electrophysiology study (EPS), reflecting conduction time through the His-Purkinje system. Fibrosis and fatty
infiltration take a role in the development of H-V interval prolongation. Recent studies claimed that fibrosis in the conduction system could be triggered by oxidative stress. Gamma-glutamyl transferase (GGT) is a non-specific marker of oxidative stress and can be practically evaluated in the clinic. The study aimed to investigate the association of H-V interval prolongation and GGT level.
Methods: The study included 94 consecutive patients (58 women) who underwent clinically indicated EPS with the diagnosis of supraventricular tachycardia. Gamma-glutamyl transferase level
was measured with routine laboratory tests before the procedure. Atrial-His, H-V intervals and basal cycle length were measured by performing the standard EPS protocol to patients.
Results: Patient’s mean age was 47.9±15.8 years. Participants were analyzed in two groups according to the duration of the H-V interval: ≤ 55 ms (n=66) and >55 ms (n=28). Body-mass index (BMI) (OR 1.153, 95% CI 1.029-1.292, p=0.014) and GGT levels (OR 1.060, 95% CI 1.013-1.108, p=0.012) were independently associated with H-V interval prolongation in multivariate logistic regression analysis.
Conclusion: Gamma-glutamyl transferase and BMI are independently associated with H-V interval prolongation. The relationship of GGT with H-V interval, which extensive studies should confirm, can be a practical aid in the follow-up of patients with infra-His conduction defects.

Keywords

Gamma-glutamyl transferase, His-Ventricle interval, Oxidative stress

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