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THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX

Year 2023, Volume: 4 Issue: Ek Sayı, 237 - 243, 16.10.2023

Abstract

Introduction: The Morning Surge Blood Pressure (MSBP) phenomenon is described as a marker an increase in morning blood pressure (BP). MSBP causes an increased risk of cardiovascular disease (CVD) and death from all causes. The atherogenic index of plasma (AIP) is used to predict the risk of coronary atherosclerosis and cardiovascular (CV) disease. In this study, we aimed to investigate the relationship between MSBP and AIP.
Methods: Our study included 296 consecutive participants with ambulatory BP monitoring. Patient data were obtained by retrospective scanning from the hospital database. The patients were divided into 3 groups according to the obtained AIP score. The relationship between MBPS and AIP risk groups was examined.
Results: After calculating the AIP value, risk classification was made. According to the risk classification; <0.11 low risk, 0.11-0.21 medium risk, and >0.21 high risk. AIP risk groups and MBPS values were compared. In the multiple regression analysis to determine the parameters associated with MSBP; age (p= 0.011), body mass index (BMI) (p= 0.001), lymphocyte level (p= 0.002), smoking (p= 0.024), male gender (p= 0.002), atrial fibrillation (AF) (p= 0.018) in the high- risk group.
Conclusion: Our retrospective study showed that increased AIP and MSBP are independently associated. A high AIP score indicates increased MSBP. However, prospective studies with large participation are needed to determine whether MSBP will be a treatment target in patients at high risk for CVD.

References

  • 1- Mendis S, Davis S, Norrving B. Organizational update: the world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke. 2015;46:e121-2.
  • 2- Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association. Circulation.2021;143:e254– 743.
  • 3- Kario K. Morning surge in blood pressure and cardiovascular risk: evidence and perspectives. Hypertension. 2010; 56:765–73.
  • 4- Metoki H, Ohkubo T, Kikuya M, et al. Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: the Ohasama study. Hypertension. 2006; 47:149–54.
  • 5- Li Y, Thijs L, Hansen TW, et al; International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators. Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations. Hypertension. 2010; 55:1040–48.
  • 6- Dobiásová M, Frohlich J. The plasma parameter log (TG/ HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoproteindepleted plasma (FER (HDL)). Clinical Biochemistry. 2001;34:583-88.
  • 7- Fernández-Macías JC, Ochoa-Martínez AC, Varela-Silva JA, Pérez-Maldonado IN. Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Archives of Medical Research. 2019;50:285-94.
  • 8- Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clinical Cardiology. 2020;43:1398-04.
  • 9- Hengel FE, Sommer C, Wenzel U. Arterielle Hypertonie. Eine Übersicht für den ärztlichen Alltag [Arterial Hypertension]. Dtsch Med Wochenschr. 2022;147:414-28.
  • 10- Bhardwaj S, Bhattacharjee J, Bhatnagar MK, Tyagi S. Atherogenic index of plasma, Castelli risk index and atherogenic coefficient- new parameters in assessing cardiovascular risk. Internatıonal Journal Of Pharmacy And Bıologıcal Scıences. 2013;3:359–64.
  • 11- Millán J, Pintó X, Muñoz A, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vascular Health and Risk Management. 2009;5:757–65.
  • 12- Ginsberg, HN. New perspectives on atherogenesis: Role of abnormal triglyceride-rich lipoprotein metabolism. Circulation. 2002;106:2137–42
  • 13- Rye KA, Bursill CA, Lambert G, Tabet F, Barter PJ. The metabolism and anti-atherogenic properties of HDL. Journal of Lipids Research. 2009;50 Suppl:S195-200.
  • 14- Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clinical Cardiology. 2020;43:1398-04.
  • 15- Nam JS, Kim MK, Nam JY, et al. Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults. Lipids in Health and Disease. 2020;19:157.
  • 16- Wang L, Chen F, Xiaoqi C, Yujun C, Zijie L. Atherogenic index of plasma is an independent risk factor for coronary artery disease and a higher SYNTAX score. Angiology 2021;72:181-86.
  • 17- Cai G, Liu W, Lv S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: a hospital-based observational study. Lipids in Health and Disease.2019;18:99
  • 18- Li YW, Kao TW, Chang PK, Chen WL, Wu LW. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Scientific Reports. 2021;11:9900.
  • 19- Kario K, Kanegae H, Hoshide S, et al. Letter Regarding Article, "Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study". Circulation. 2021;143:e982-83.
  • 20- Rubin S, Cremer A, Boulestreau R, Rigothier C, Kuntz S, Gosse P. Malignant hypertension: diagnosis, treatment and prognosis with experience from the Bordeaux cohort. Journal of Hypertension. 2019;37:316-24.
  • 21- Kıvrak A, Ozbicer S, Kalkan GY, Gür M. Morning blood pressure surge and arterial stiffness in newly diagnosed hypertensive patients. Blood Pressure. 2017;26:181-90.
  • 22- Kaypaklı O, Gür M, Harbalıoğlu H, Seker T, Selek S. High morning blood pressure surge is associated with oxidative stress and paraoxonase 1 activity in newly diagnosed hypertensive patients. Clinical and Experimental Hypertension. 2016;38:680-85.

ATEROJENİK İNDEX İLE SABAH KAN BASINCI DALGALANMASI ARASINDAKİ İLİŞKİ

Year 2023, Volume: 4 Issue: Ek Sayı, 237 - 243, 16.10.2023

Abstract

Giriş: Sabah Kan Basıncı Dalgalanması (SKBD) fenomeni, sabah kan basıncında (KB) belirgin bir artış olarak tanımlanır. SKBD, kardiyovasküler hastalık (KVH) riskinde artışa ve tüm nedenlere bağlı ölümlere neden olur. Plazma aterojenite indeksi (PAİ), koroner ateroskleroz ve kardiyovasküler (KV) hastalık riskini tahmin etmek için kullanılır. Bu çalışmada SKBD ve PAİ arasındaki ilişkiyi incelemeyi amaçladık.
Yöntemler: Çalışmamıza ambulatuvar KB izlemesi olan 296 ardışık katılımcı dahil edildi. Hasta bilgileri hastane veri tabanından geriye dönük tarama yapılarak elde edildi. Elde edilen PAİ skoruna göre hastalar 3 gruba ayrıldı. SKBD ve PAİ risk grupları arasındaki ilişki incelenmiştir.
Bulgular: PAİ değeri hesaplandıktan sonra risk sınıflandırması yapıldı. Risk sınıflandırmasına göre; <0,11 düşük risk, 0,11-0,21 orta risk ve >0,21 yüksek risk. PAİ risk grupları ve SKBD değerleri karşılaştırıldı. SKBD ile PAİ arasında korelasyon saptandı. SKBD ile ilişkili parametreleri belirlemek için yapılan çoklu regresyon analizinde; yüksek risk grubunda yaş (p= 0,011), vücut kitle indeksi (VKİ) (p= 0,001), lenfosit düzeyi (p= 0,002), sigara içme (p= 0,024), erkek cinsiyet (p= 0,002), atriyal fibrilasyon (AF) (p= 0,018) ilişkili bulundu.
Sonuç: Çalışmamızın sonuçları artmış PAİ ve SKBD'nin bağımsız olarak ilişkili olduğunu göstermektedir. Yüksek PAİ puanı, artmış SKBD'yi gösterir. Ancak KVH açısından yüksek risk taşıyan hastalarda SKBD'nin bir tedavi hedefi olup olmayacağının belirlenmesi için gelişmiş çalışmalara ihtiyaç vardır.

References

  • 1- Mendis S, Davis S, Norrving B. Organizational update: the world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke. 2015;46:e121-2.
  • 2- Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association. Circulation.2021;143:e254– 743.
  • 3- Kario K. Morning surge in blood pressure and cardiovascular risk: evidence and perspectives. Hypertension. 2010; 56:765–73.
  • 4- Metoki H, Ohkubo T, Kikuya M, et al. Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: the Ohasama study. Hypertension. 2006; 47:149–54.
  • 5- Li Y, Thijs L, Hansen TW, et al; International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators. Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations. Hypertension. 2010; 55:1040–48.
  • 6- Dobiásová M, Frohlich J. The plasma parameter log (TG/ HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoproteindepleted plasma (FER (HDL)). Clinical Biochemistry. 2001;34:583-88.
  • 7- Fernández-Macías JC, Ochoa-Martínez AC, Varela-Silva JA, Pérez-Maldonado IN. Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Archives of Medical Research. 2019;50:285-94.
  • 8- Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clinical Cardiology. 2020;43:1398-04.
  • 9- Hengel FE, Sommer C, Wenzel U. Arterielle Hypertonie. Eine Übersicht für den ärztlichen Alltag [Arterial Hypertension]. Dtsch Med Wochenschr. 2022;147:414-28.
  • 10- Bhardwaj S, Bhattacharjee J, Bhatnagar MK, Tyagi S. Atherogenic index of plasma, Castelli risk index and atherogenic coefficient- new parameters in assessing cardiovascular risk. Internatıonal Journal Of Pharmacy And Bıologıcal Scıences. 2013;3:359–64.
  • 11- Millán J, Pintó X, Muñoz A, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vascular Health and Risk Management. 2009;5:757–65.
  • 12- Ginsberg, HN. New perspectives on atherogenesis: Role of abnormal triglyceride-rich lipoprotein metabolism. Circulation. 2002;106:2137–42
  • 13- Rye KA, Bursill CA, Lambert G, Tabet F, Barter PJ. The metabolism and anti-atherogenic properties of HDL. Journal of Lipids Research. 2009;50 Suppl:S195-200.
  • 14- Won KB, Jang MH, Park EJ, et al. Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study. Clinical Cardiology. 2020;43:1398-04.
  • 15- Nam JS, Kim MK, Nam JY, et al. Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults. Lipids in Health and Disease. 2020;19:157.
  • 16- Wang L, Chen F, Xiaoqi C, Yujun C, Zijie L. Atherogenic index of plasma is an independent risk factor for coronary artery disease and a higher SYNTAX score. Angiology 2021;72:181-86.
  • 17- Cai G, Liu W, Lv S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: a hospital-based observational study. Lipids in Health and Disease.2019;18:99
  • 18- Li YW, Kao TW, Chang PK, Chen WL, Wu LW. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Scientific Reports. 2021;11:9900.
  • 19- Kario K, Kanegae H, Hoshide S, et al. Letter Regarding Article, "Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study". Circulation. 2021;143:e982-83.
  • 20- Rubin S, Cremer A, Boulestreau R, Rigothier C, Kuntz S, Gosse P. Malignant hypertension: diagnosis, treatment and prognosis with experience from the Bordeaux cohort. Journal of Hypertension. 2019;37:316-24.
  • 21- Kıvrak A, Ozbicer S, Kalkan GY, Gür M. Morning blood pressure surge and arterial stiffness in newly diagnosed hypertensive patients. Blood Pressure. 2017;26:181-90.
  • 22- Kaypaklı O, Gür M, Harbalıoğlu H, Seker T, Selek S. High morning blood pressure surge is associated with oxidative stress and paraoxonase 1 activity in newly diagnosed hypertensive patients. Clinical and Experimental Hypertension. 2016;38:680-85.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Oğuz Kılıç 0000-0002-5126-0959

İpek Büber 0000-0003-2457-313X

Early Pub Date October 16, 2023
Publication Date October 16, 2023
Published in Issue Year 2023 Volume: 4 Issue: Ek Sayı

Cite

APA Kılıç, O., & Büber, İ. (2023). THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX. Eskisehir Medical Journal, 4(Ek Sayı), 237-243.
AMA Kılıç O, Büber İ. THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX. Eskisehir Med J. October 2023;4(Ek Sayı):237-243.
Chicago Kılıç, Oğuz, and İpek Büber. “THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX”. Eskisehir Medical Journal 4, no. Ek Sayı (October 2023): 237-43.
EndNote Kılıç O, Büber İ (October 1, 2023) THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX. Eskisehir Medical Journal 4 Ek Sayı 237–243.
IEEE O. Kılıç and İ. Büber, “THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX”, Eskisehir Med J, vol. 4, no. Ek Sayı, pp. 237–243, 2023.
ISNAD Kılıç, Oğuz - Büber, İpek. “THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX”. Eskisehir Medical Journal 4/Ek Sayı (October 2023), 237-243.
JAMA Kılıç O, Büber İ. THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX. Eskisehir Med J. 2023;4:237–243.
MLA Kılıç, Oğuz and İpek Büber. “THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX”. Eskisehir Medical Journal, vol. 4, no. Ek Sayı, 2023, pp. 237-43.
Vancouver Kılıç O, Büber İ. THE RELATIONSHIP OF MORNING SURGE in BLOOD PRESSURE and ATHEROGENIC INDEX. Eskisehir Med J. 2023;4(Ek Sayı):237-43.