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KORONER YAVAŞ AKIM FENOMENİ İLE ENDOTEL NİTRİK OKSİT SENTAZ'IN GLU298ASP VE T786-C GEN POLİMORFİZMLERI ARASINDAKİ İLİŞKİ

Year 2023, Volume: 4 Issue: Ek Sayı, 201 - 206, 16.10.2023

Abstract

Giriş: Çalışmada Endotelyal Nitrik Oksit Sentaz Glu 298-Asp Ve T786- C gen polimorfizmleri ile koroner yavaş akım arasındaki ilişkinin belirlenmesi amaçlanmıştır.
Yöntemler: Çalışmaya anginal yakınmalar, efor testi veya miyokard perfüzyon sintigrafisi sonucuna göre koroner anjiyografi yapılan 148 birey alındı. Koroner akım TIMI çerçeve sayısına göre hesaplandı. Hastalardan, gen analizi ve diğer biyokimyasal parametreler için venöz kan örneği alındı.
Bulgular: Yapılan koroner anjiyografi işlemi sonucunda TIMI çerçeve sayısına göre koroner yavaş akım saptanan 74 birey hasta olarak ve normal koroner saptanan 74 birey kontrol grubu olarak alındı. Hasta ve kontrol grubunun genotipik polimorfizm incelemesinde T786-C polimorfizminde CC, CT ve TT genotipine sahip bireyler arasında (p=0.941) ve Glu298-Asp polimorfizminde GG, GT ve TT genotipine sahip bireyler arasında (p=0.070) anlamlı fark saptanmadı. Ayrıca koroner yavaş akımın tek damar tutulumu (LAD, CX veya RCA’dan yalnızca birinde) veya çok damar tutulumuna (LAD, CX veya RCA’dan en az iki veya daha fazlasında) göre dağılımı incelendiğinde T-786 C (p=0.220) ve Glu298-asp (p=0.378) polimorfizminin genotiplerinin dağılımı açısından istatiksel anlam bulunmadı.
Sonuç: Çalışmamız, Türk toplumunda eNOS geninin T786-c ve Glu298-asp polimorfizmleri ile koroner yavaş akım fenomeni arasında ilişki olmadığını göstermiştir.

References

  • 1. Tambe A, Demany M, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries-a new angiographic finding. Am Heart J. 1972;84:66-71.
  • 2. Goel PK, Gupta SK, Agarwal A, Kapoor A. Slow coronary flow: a distinct angiographic subgroup in syndrome X. Angiology. 2001;52:507-14.
  • 3. Mangieri E, Macchiarelli G, Ciavolella M, et al. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn. 1996;37:375-81.
  • 4. Burckhartt BA, Mukerji V, Alpert MA. Coronary artery slow flow associated with angina pectoris and hypotension: a case report. Angiology. 1998;49:483-7.
  • 5. Gökçe M, Kaplan S, Tekelioǧlu Y, Erdoǧan T, Küçükosmanoǧlu M. Platelet function disorder in patients with coronary slow flow. Clin Cardiol. 2005;28:145-8.
  • 6. Lanza G, Andreotti F, Sestito A, Sciahbasi A, Crea F, Maseri A. Platelet aggregability in cardiac syndrome X. Eur Heart J. 2001;22:1924-30.
  • 7. Rim S-J, Leong-Poi H, Lindner JR, Wei K, Fisher NG, Kaul S. Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity. Circulation. 2001;104:2704-9.
  • 8. Forssmann W. Die sondierung des rechten herzens. Klin Wochenschr. 1929;8:2085-7.
  • 9. Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci. 1997;22:477-81.
  • 10. Wang XL, Sim AS, Badenhop RF, Mccredie RM, Wilcken DE. A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med. 1996;2:41-5.
  • 11. Yoshimura M, Yasue H, Nakayama M, et al. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 1998;103:65-9.
  • 12. Rossi GP, Cesari M, Zanchetta M, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol. 2003;41:930-7.
  • 13. Camsarl A, Pekdemir H, Cicek D, et al. Endothelin-1 and nitric oxide concentrations and their response to exercise in patients with slow coronary flow. Circ J. 2003;67:1022-8.
  • 14. Sezgin N, Barutcu I, Sezgin AT, et al. Plasma nitric oxide level and its role in slow coronary flow phenomenon. Int Heart J. 2005;46:373-82.
  • 15. Gupta MD, Akkarappatty C, Girish MP, et al. Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population. Coron Artery Dis. 2014;25:192-7.
  • 16. Caglayan AO, Kalay N, Saatci C, Yalcın A, Akalın H, Dundar M. Lack of association between the Glu298Asp polymorphism of endothelial nitric oxide synthase and slow coronary flow in the Turkish population. Can J Cardiol. 2009;25:e69-e72.
  • 17. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879-88.
  • 18. Schmidt H. Walter U. NO at work. Cell. 1994;78:919-25.
  • 19. Chauhan A, Mullins P, Taylor G, Petch M, Schofield P. Both endothelium-dependent and endothelium-independent function is impaired in patients with angina pectoris and normal coronary angiograms. Eur Heart J. 1997;18:60-8.
  • 20. Lanza GA, Lüscher TF, Pasceri V, et al. Effects of atrial pacing on arterial and coronary sinus endothelin-1 levels in syndrome X. Am J Cardiol. 1999;84:1187-91.
  • 21. Pekdemir H, Polat G, Cin VG, et al. Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slow coronary flow. Int J Cardiol. 2004;97:35-41.
  • 22. Gazi E, Temiz A, Altun B, et al. Endothelial function and germ-line ACE I/D, eNOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population: multiple thrombophilic gene profiles in coronary slow flow. Cardiovasc J Afr. 2014;25:9.
  • 23. Nurkalem Z, Tangurek B, Zencirci E, et al. Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow. Coron Artery Dis. 2008;19:85-8.
  • 24. Chang K, Baek SH, Seung K-B, et al. The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm. Coron Artery Dis. 2003;14:293-9.
  • 25. Rossi GP, Taddei S, Virdis A, et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol. 2003;41:938-45.
  • 26. Kacmaz Y, Gurlertop YH, Turgay Yildirim O, Aksit E, Aydin F. Glu 298-Asp and T786-C Polymorphisms of Endothelial Nitric Oxide Synthase Gene in Coronary Artery Disease Patients. Acta Med. Alanya 2019;3: 40-48.

THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON

Year 2023, Volume: 4 Issue: Ek Sayı, 201 - 206, 16.10.2023

Abstract

Introduction: This study aims to determine the association between Glu 298-Asp and T786-C gene polymorphisms of endothelial nitric oxide synthase (eNOS) and coronary slow-flow (CSF) phenomenon.
Methods: 148 individuals who underwent coronary angiogram (CAG) based on anginal symptoms, exercise testing, or myocardial perfusion scintigraphy were included in the study. Coronary flow was calculated based on TIMI frame counts (TFCs) on CAG. Venous blood samples were drawn from the patients for gene analysis and other biochemical parameters.
Results: 74 patients with a CSF pattern based on TFCs were included as patients and 74 individuals with normal coronary arteries were included as the control group. In the genotypic polymorphism analysis of the patient and control groups, no significant difference was found among individuals with CC, CT, and TT genotypes in terms of T786- C polymorphism (p=0.941) and among individuals with GG, GT, and TT genotypes (p=0.070) in terms of Glu298Asp polymorphism. Also, there was no statistically significant difference with regard to the distribution of the T786-C (p=0.220) and Glu298Asp (p=0.378) polymorphisms between those with single (only one of LAD, CX, or RCA) and those with multi-vessel (at least two or more of LAD, CX, or RCA) CSF patterns.
Conclusion: Our study demonstrated a null relationship between T786-C and Glu298Asp polymorphisms of the eNOS gene and CSF phenomenon in the Turkish population.

References

  • 1. Tambe A, Demany M, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries-a new angiographic finding. Am Heart J. 1972;84:66-71.
  • 2. Goel PK, Gupta SK, Agarwal A, Kapoor A. Slow coronary flow: a distinct angiographic subgroup in syndrome X. Angiology. 2001;52:507-14.
  • 3. Mangieri E, Macchiarelli G, Ciavolella M, et al. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn. 1996;37:375-81.
  • 4. Burckhartt BA, Mukerji V, Alpert MA. Coronary artery slow flow associated with angina pectoris and hypotension: a case report. Angiology. 1998;49:483-7.
  • 5. Gökçe M, Kaplan S, Tekelioǧlu Y, Erdoǧan T, Küçükosmanoǧlu M. Platelet function disorder in patients with coronary slow flow. Clin Cardiol. 2005;28:145-8.
  • 6. Lanza G, Andreotti F, Sestito A, Sciahbasi A, Crea F, Maseri A. Platelet aggregability in cardiac syndrome X. Eur Heart J. 2001;22:1924-30.
  • 7. Rim S-J, Leong-Poi H, Lindner JR, Wei K, Fisher NG, Kaul S. Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity. Circulation. 2001;104:2704-9.
  • 8. Forssmann W. Die sondierung des rechten herzens. Klin Wochenschr. 1929;8:2085-7.
  • 9. Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci. 1997;22:477-81.
  • 10. Wang XL, Sim AS, Badenhop RF, Mccredie RM, Wilcken DE. A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med. 1996;2:41-5.
  • 11. Yoshimura M, Yasue H, Nakayama M, et al. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 1998;103:65-9.
  • 12. Rossi GP, Cesari M, Zanchetta M, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol. 2003;41:930-7.
  • 13. Camsarl A, Pekdemir H, Cicek D, et al. Endothelin-1 and nitric oxide concentrations and their response to exercise in patients with slow coronary flow. Circ J. 2003;67:1022-8.
  • 14. Sezgin N, Barutcu I, Sezgin AT, et al. Plasma nitric oxide level and its role in slow coronary flow phenomenon. Int Heart J. 2005;46:373-82.
  • 15. Gupta MD, Akkarappatty C, Girish MP, et al. Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population. Coron Artery Dis. 2014;25:192-7.
  • 16. Caglayan AO, Kalay N, Saatci C, Yalcın A, Akalın H, Dundar M. Lack of association between the Glu298Asp polymorphism of endothelial nitric oxide synthase and slow coronary flow in the Turkish population. Can J Cardiol. 2009;25:e69-e72.
  • 17. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879-88.
  • 18. Schmidt H. Walter U. NO at work. Cell. 1994;78:919-25.
  • 19. Chauhan A, Mullins P, Taylor G, Petch M, Schofield P. Both endothelium-dependent and endothelium-independent function is impaired in patients with angina pectoris and normal coronary angiograms. Eur Heart J. 1997;18:60-8.
  • 20. Lanza GA, Lüscher TF, Pasceri V, et al. Effects of atrial pacing on arterial and coronary sinus endothelin-1 levels in syndrome X. Am J Cardiol. 1999;84:1187-91.
  • 21. Pekdemir H, Polat G, Cin VG, et al. Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slow coronary flow. Int J Cardiol. 2004;97:35-41.
  • 22. Gazi E, Temiz A, Altun B, et al. Endothelial function and germ-line ACE I/D, eNOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population: multiple thrombophilic gene profiles in coronary slow flow. Cardiovasc J Afr. 2014;25:9.
  • 23. Nurkalem Z, Tangurek B, Zencirci E, et al. Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow. Coron Artery Dis. 2008;19:85-8.
  • 24. Chang K, Baek SH, Seung K-B, et al. The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm. Coron Artery Dis. 2003;14:293-9.
  • 25. Rossi GP, Taddei S, Virdis A, et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol. 2003;41:938-45.
  • 26. Kacmaz Y, Gurlertop YH, Turgay Yildirim O, Aksit E, Aydin F. Glu 298-Asp and T786-C Polymorphisms of Endothelial Nitric Oxide Synthase Gene in Coronary Artery Disease Patients. Acta Med. Alanya 2019;3: 40-48.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Cihan Öztürk 0000-0001-8694-1693

Metin Budak 0000-0002-5968-2048

Gökay Taylan 0000-0002-7015-4537

Kenan Yalta 0000-0001-5966-2488

Early Pub Date October 16, 2023
Publication Date October 16, 2023
Published in Issue Year 2023 Volume: 4 Issue: Ek Sayı

Cite

APA Öztürk, C., Budak, M., Taylan, G., Yalta, K. (2023). THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON. Eskisehir Medical Journal, 4(Ek Sayı), 201-206.
AMA Öztürk C, Budak M, Taylan G, Yalta K. THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON. Eskisehir Med J. October 2023;4(Ek Sayı):201-206.
Chicago Öztürk, Cihan, Metin Budak, Gökay Taylan, and Kenan Yalta. “THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON”. Eskisehir Medical Journal 4, no. Ek Sayı (October 2023): 201-6.
EndNote Öztürk C, Budak M, Taylan G, Yalta K (October 1, 2023) THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON. Eskisehir Medical Journal 4 Ek Sayı 201–206.
IEEE C. Öztürk, M. Budak, G. Taylan, and K. Yalta, “THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON”, Eskisehir Med J, vol. 4, no. Ek Sayı, pp. 201–206, 2023.
ISNAD Öztürk, Cihan et al. “THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON”. Eskisehir Medical Journal 4/Ek Sayı (October 2023), 201-206.
JAMA Öztürk C, Budak M, Taylan G, Yalta K. THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON. Eskisehir Med J. 2023;4:201–206.
MLA Öztürk, Cihan et al. “THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON”. Eskisehir Medical Journal, vol. 4, no. Ek Sayı, 2023, pp. 201-6.
Vancouver Öztürk C, Budak M, Taylan G, Yalta K. THE RELATIONSHIP BETWEEN GLU298ASP AND T786-C GENE POLYMORPHISMS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CORONARY SLOW-FLOW PHENOMENON. Eskisehir Med J. 2023;4(Ek Sayı):201-6.