SYSTEMIC IMMUNE-INFLAMMATION INDEX IS A PREDICTOR OF LEFT VENTRICULAR THROMBUS FORMATION FOLLOWING ANTERIOR MYOCARDIAL INFARCTION

Year 2023, Volume: 4 Issue: Ek Sayı, 188 - 194, 16.10.2023

Ahmet Lütfü Sertdemir , Mustafa Duran , Ahmet Taha Şahin , Abdullah İçli , Mustafa Çelik , Sefa Tatar , Yakup Alsancak

Abstract

Introduction: Left ventricular thrombus (LVT) formation following anterior ST-elevation myocardial infarction (STEMI), is a serious complication and is associated with an increased risk of cardiovascular morbidity and mortality. Recently introduced the systemic immune-inflammation index (SII) is a reliable indicator of adverse events in various cardiovascular conditions. Herein, we aimed to explore the role of SII in the prediction of LVT formation in anterior STEMI patients following primary percutaneous coronary intervention (PCI).
Methods: Medical records of 124 anterior STEMI patients who developed LVT following primary PCI and 124 age and sex-matched anterior STEMI patients without formation of LVT following primary PCI were analyzed. For each group, patient demographics, comorbidities, laboratory parameters, ECG and echocardiographic findings were analyzed. The SII was measured using the following formula: SII= total peripheral platelets count x neutrophil/lymphocyte ratio.
Results: According to our study, reduced left ventricular ejection fraction and increased SII were identified as independent predictors of LVT formation following anterior STEMI. To determine the SII index cut-off value for predicting LVT formation, the ROC curve was drawn and the best cut-off value was determined as 676.27 (AUC:0.778, 95% CI:0.699-0.858, p<0.001). Above this cut-off value, LVT formation could be predicted with a sensitivity of 66.1% and a specificity of 74.2%.
Conclusion: SII is may be used as an independent predictor of LVT formation for anterior STEMI patients following primary PCI.

Keywords

Left ventricular thrombus, ST-elevation myocardial infarction, systemic immune-inflammation index.

SİSTEMİK İMMÜN-ENFLAMASYON İNDEKSİ, ANTERİOR MİYOKARD ENFARKTÜSÜNÜ TAKİBEN SOL VENTRIKÜL TROMBÜS OLUŞUMUNUN BİR GÖSTERGESİ

Abstract

Giriş: Anterior ST yükselmeli miyokard infarktüsünü (STEMI) takiben sol ventrikül trombüsü (SVT) oluşumu ciddi bir komplikasyondur ve artmış kardiyovasküler morbidite ve mortalite riski ile ilişkilidir. Son zamanlarda tanıtılan sistemik immün-enflamasyon indeksi (SII), çeşitli kardiyovasküler durumlardaki olumsuz olayların güvenilir bir göstergesidir. Burada, primer perkütan koroner girişim (PKG) sonrası anterior STEMI hastalarında SII'nin SVT oluşumunu öngörmedeki rolünü araştırmayı amaçladık.
Yöntemler: Primer PKG sonrası SVT gelişen 124 anterior STEMI hastasının ve primer PKG sonrası SVT oluşmayan yaş ve cinsiyet uyumlu 124 anterior STEMI hastasının tıbbi kayıtları analiz edildi. Her grup için hasta demografik özellikleri, komorbiditeler, laboratuvar parametreleri, EKG ve ekokardiyografik bulgular analiz edildi. SII, aşağıdaki formül kullanılarak ölçüldü: SII= toplam periferik trombosit sayısı x nötrofil/lenfosit oranı.
Bulgular: Çalışmamıza göre, azalmış sol ventrikül ejeksiyon fraksiyonu ve artmış SII, anterior STEMI sonrası SVT oluşumunun bağımsız belirteçleri olarak belirlendi. SII indeksi cut-off değerinin SVT oluşumunu öngörmede belirlenmesi için ROC eğrisi çizildi ve en iyi cut- off değeri 676,27 olarak belirlendi (AUC:0,778, 95% CI:0,699-0,858, p<0,001). Bu cut-off değerinin üzerinde %66,1 sensitivite ve %74,2 spesifite ile SVT oluşumu tahmin edilebildi.
Sonuç: SII, primer PKG sonrası anterior STEMI hastalarında SVT oluşumunun bağımsız bir göstergesi olabilir.

Keywords

sistemik immün-enflamasyon indeksi, Sol ventrikül trombüsü, ST yükselmeli miyokard enfarktüsü

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