Evaluation of the Predictive Ability of Laboratory Parameters in Fibromyalgia Syndrome Compared to Individuals with Local Musculoskeletal Pain

Year 2025, Volume: 6 Issue: 1, 70 - 74, 15.03.2025

Burcu Ayık , Gizem Sarıçimen

Abstract

Introduction: Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread pain and various somatic symptoms. This study aims to investigate the differences between FMS patients and individuals with localized musculoskeletal disorders by evaluating inflammatory and metabolic markers that may play a role in FMS pathogenesis.

Methods: This retrospective study included 43 patients diagnosed with FMS and 43 patients with localized musculoskeletal pain, aged between 30 and 65 years. White blood cell count (WBC), red cell distribution width (RDW), mean corpuscular haemoglobin concentration (MCHC), mean platelet volume (MPV), platelet distribution width (PDW), albumin, creatinine, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) values of the participants were recorded. Additionally, CRP/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic inflammatory indices (SII) of the participants were calculated.

Results: The mean ages were similar between the two groups in our study (Group 1 mean age: 46.76±8.94 years and Group 2 mean age: 46.3±8.67 years). MPV levels were found to be statistically significantly higher in the FMS group compared to the group with localized pain (p=0.02). No statistically significant difference was detected between the two groups in terms of the other evaluated laboratory parameters.

Conclusions: According to our research, we found a statistically significant difference only in MPV levels between FMS patients and controls. This suggests that it may help facilitate the diagnosis of FMS patients.

Keywords

fibromyalgia, inflammation, laboratory parameters, mean platelet volume, pain

Ethical Statement

This study was approved by Eskisehir Osmangazi University Ethics Committee (Date:31.10.2023 and number: 50) and the study adhered to the principles outlined in the Declaration of Helsinki.

Lokal Kas-İskelet Ağrılı Bireylerle Karşılaştırıldığında Fibromiyalji Sendromunda Laboratuar Parametrelerinin Öngörü Yeteneğinin Değerlendirilmesi

Abstract

Giriş: Fibromiyalji sendromu (FMS) yaygın ağrı ve çeşitli somatik semptomlarla karakterize bir kronik ağrı sendromudur. Bu çalışmanın amacı, FMS patogenezinde rol oynayabilecek inflamatuar ve metabolik belirteçleri değerlendirerek FMS hastaları ile lokalize kas-iskelet sistemi rahatsızlığı olan bireyler arasındaki farklılıkları araştırmaktır.

Yöntemler: Bu retrospektif çalışmaya 30-65 yaş arası 43 FMS tanılı hasta ve 43 lokalize kas-iskelet bozukluğu olan hasta dahil edildi. Katılımcıların beyaz kan hücresi sayımı (WBC), kırmızı hücre dağılım genişliği (RDW), ortalama eritrosit hemoglobin konsantrasyonu (MCHC), ortalama trombosit hacmi (MPV), trombosit dağılım genişliği (PDW), albümin, kreatinin, eritrosit sedimantasyon hızı (ESR) ve C-reaktif protein (CRP) değerleri not edildi. Ayrıca katılımcıların CRP/albümin oranı (CAR), nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR), monosit/lenfosit oranı (MLR) ve sistemik inflamatuar indeksleri (SII) hesaplandı.

Bulgular: Çalışmamızda yaş ortalamaları her iki grupta da benzerdi (1. grup yaş: 46,76±8,94 yıl ve 2. grup yaş: 46,3±8,67 yıl). FMS grubunda MPV düzeyleri lokalize ağrısı olan gruba göre istatistiksel olarak anlamlı farkla daha yüksek bulundu (p=0,02). Değerlendirdiğimiz diğer laboratuvar parametreleri açısından iki grup arasında istatistiksel anlamlı fark tespit edilmedi.

Sonuç: Araştırmamıza göre FMS hastaları ile kontroller arasında sadece MPV düzeylerinde istatistiksel olarak anlamlı fark bulduk. FMS hastalarının tanısını kolaylaştırmada faydalı olabileceğini düşündürmektedir.

Keywords

fibromiyalji, inflamasyon, laboratuvar parametreleri, ortalama trombosit hacmi, ağrı

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