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Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies

Year 2025, Volume: 6 Issue: 1, 36 - 44, 15.03.2025

Abstract

Introduction: Our study aims to determine the effectiveness of check-up programs in the early diagnosis of benign and malignant pathologies, and evaluate their importance.

Methods: Posteroanterior chest X-ray, thyroid, and abdominal ultrasonography were performed. Breast ultrasonography was performed on all females and mammography on those over 40 years. Fecal occult blood, carcinoembryonic antigen, and prostate-specific antigen tests were performed on the cases along with hemogram and routine biochemical tests. Radiological images and reports were retrospectively scanned, and fecal occult blood, carcinoembryonic antigen, and prostate-specific antigen values were examined. Breast Imaging Reporting and Data Systems (BIRADS) in breast radiology and the Thyroid Imaging Reporting and Data System (TIRADS) in thyroid radiology were used for classification.

Results: 1411 cases were included in this study. 49.4% were female and 50.6% male. Median age was 50 years. Benign lesions in the liver were detected in 5.31% of the cases, kidney stones in 4.7%, and cholelithiasis in 5.7%. Benign Prostatic Hyperplasia was observed in 20% of the males. Thyroid gland nodule with a risk of malignancy in 3.8% and biopsy was recommended. Malignancy-suspicious lesions were detected in 0.28%, that performed breast ultrasonography and in 0.8%, that performed mammography, and biopsy was recommended. Normal lung parenchymal findings were detected in 75.4%, minor in 22%, and major in 2.6%, and thoracic computed tomography was recommended.

Conclusions: Effective check-up programs are found to be beneficial for public health as they provide diagnosis and follow-up in benign lesions and early diagnosis and treatment opportunities in malignant/premalignant lesions.

Ethical Statement

The approval of this study in accordance with the ethical rules of the Declaration of Helsinki was approved by the ethics committee of İstanbul Okan University at the meeting numbered 169 on 18.10.2023 with decision number 35.

Supporting Institution

No person/organization financially supports the study.

References

  • Diaz Hernandez L, Giezendanner S, Fischer R, Zeller A. Expectations about check-up examinations among Swiss residents: A nationwide population-based cross-sectional survey. PLoS One 2021;16:e0254700.
  • Krogsbøll LT, Jørgensen KJ, Gøtzsche PC. General health checks in adults for reducing morbidity and mortality from disease. Cochrane Database Syst Rev 2019; 31;1:CD009009.
  • Sickles EA, D’Orsi CJ, Bassett LW, et al. ACR BI-RADS Mammography. In: ACR BI-RADS Atlas, Breast Imaging Reporting and Data System, 5th Edition, American College of Radiology 2013;134-36.
  • Orel SG, Kay N, Reynolds C, Sullivan DC. BI-RADS categorization as a predictor of malignancy. Radiology 1999;211:845-50.
  • Tessler FN, Middleton WD, Grant EG, et al. ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS committee. Journal of the American College of Radiology 2017;14:587–95.
  • Modi L, Sun W, Shafizadeh N, et al. Does a higher American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI‐RADS) score forecast an increased risk of malignancy? A correlation study of ACR TI‐RADS with FNA cytology in the evaluation of thyroid nodules. Cancer Cytopathology 2020;128:470-81.
  • Singaporewalla RM, Hwee J, Lang TU, Desai V. Clinico-pathological Correlation of Thyroid Nodule Ultrasound and Cytology Using the TIRADS and Bethesda Classifications. World J Surg 2017;41:1807-11.
  • Kim J, Kim KH. Role of chest radiographs in early lung cancer detection. Transl Lung Cancer Res 2020;9:522–31.
  • Okaniwa S, Hirai T, Ogawa M, et al. Working Group on Revision of the Manual for Abdominal Ultrasound in Cancer Screening and Health Checkups, Ultrasound Screening Committee of the Japanese Society of Gastrointestinal Cancer Screening. J Med Ultrason 2023;50:45–9.
  • Wang F, Numata K, Nihonmatsu H, Okada M, Maeda S. Application of new ultrasound techniques for focal liver lesion. J Med Ultrason 2020;47:215-37.
  • Hernaez R, Lazo M, Bonekamp S, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011;54:1082–90.
  • Popescu A, Sporea I. Ultrasound examination of normal gall bladder and biliary system. Med Ultrason 2010;12:150-2.
  • Nicolau C, Antunes N, Paño B, Sebastia C. Imaging Characterization of Renal Masses. Medicina (Kaunas) 2021;51:57.
  • Sherlock M, Scarsbrook A, Abbas A, et al. Adrenal Incidentaloma. Endocr Rev 2020; 41:775–820.
  • Yeşilkaya Y, Akata D. Kadın genital sistemin sonografik değerlendirilmesi. Türkiye Klinikleri Radyoloji-Özel Konular 2010;3-1.
  • Sirli R, Sporea I. Ultrasound examination of the normal pancreas. Med Ultrason. 2010;12:62-5.
  • Ciaravino V, D'Onofrio M. Pancreatic Ultrasound: State of the Art. J Ultrasound Med 2019;38:1125-37.
  • Chen MJ, Huang MJ, Chang WH, et al. Ultrasonography of splenic abnormalities. World J Gastroenterol 2005;11:4061-66.
  • Wen YH, Chang PY, Hsu CM, Wang HY, Chiu CT, Lu JJ. Cancer screening through a multi-analyte serum biomarker panel during health check-up examinations: Results from a 12-year experience. Clinica chimica açta 2015;450:273-76.
  • Rosita L, Occifa GA. Analysis of Prostate Specific Antigen (PSA) level on Medical Check-up (MCU) Participants. Bali Medical Journal 2019;8:267-69.
  • Huang H, Rong Y, Wang M, et al. Analysis of gastroscopy results among healthy people undergoing a medical checkup: a retrospective study. BMC gastroenterology 2020;20:1-9.
  • Vleugels JL, Van Lanschot MC, Dekker E. (2016). Colorectal cancer screening by colonoscopy: putting it into perspective. Digestive Endoscopy 2016;28:250-59.
  • Mizuma Y, Watanabe Y, Ozasa K, et al. Validity of sonographic screening for the detection of abdominal cancers. Journal of clinical ultrasound 2002;30:408-15.
  • Portincasa P, Moschetta A, Petruzzelli M, Palasciano G, Di Ciaula A, Pezzolla A. Gallstone disease: Symptoms and diagnosis of gallbladder stones. Best Pract Res Clin Gastroenterol 2006;20:1017-29.
  • Adem Y, Coşkun M, Turgut HT, Özyıldız M, Yazıcıoğlu MB, Yıldız SY. Ultrasonografide safra kesesinde polip saptanan hastaların postoperatif histopatolojik bulgularının analizi. Kocaeli Medical Journal 2016;5:1:11-5.
  • Serter S, Ceylan C, Tunçyürek Ö, Örgüç Ş, Pabuçcu Y. Sonographic evaluation of spleen size and prevalence of accessory spleen in a healthy male Turkish population. Turk J Haematol 2010;27:25-8.
  • Ciaravino V, D'Onofrio M. Pancreatic ultrasound: state of the art. Journal of Ultrasound in Medicine 2019;38:1125-37.
  • Liu YX, Wang JZ, Liu JP, Pang CK, Jia HY. Imaging diagnosis for fatty liver: a systematic review. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004;26:580-4.
  • İmamoğlu FG, İmamoğlu Ç, Çiledağ N, Arda K, Tola M, Düzgöl C. Karaciğer Yağlanmasının Ultrasonografi ile Sınıflandırılması ve Yağlanma Derecesinin Karaciğer Fonksiyon Testleri Üzerine Etkisinin İncelenmesi. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 2015;2:23-8.
  • Wanless IR. Benign liver tumors. Clin Liver Dis 2002;6:513-26.
  • Mortele KJ, Praet M, Van Vlierberghe H, Kunnen M, Ros PR. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. AJR Am J Roentgenol 2000;175:687-92.
  • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020–22.
  • Walz PH, Bertermann H. Ultrasound examination of bladder and prostate. Urol Int. 1990;45:217-30.
  • Kang SK, Huang WC, Pandharipande PV, Chandarana H. Solid renal masses: What the numbers tell us. AJR Am. J. Roentgenol 2014;202:1196–1206.
  • Luczynska E, Zbigniew K. Diagnostic imaging in gynecology. Ginekologia Polska 2022;93:63-9.
  • Hoffman RM, Sanchez R. Lung Cancer Screening. Med Clin North Am 2017;101:769-85.
  • Obenauer S, Hermann KP, Grabbe E. Applications and literature review of the BI-RADS classification. European radiology 2005;15:1027-36.
  • Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European Thyroid Association guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults: the EU-TIRADS. European thyroid journal 2017;6:225-37.
  • Utku ÖG, Ergül B, Oğuz D. Gaitada gizli kan testi pozitifliği nedeni ile kolonoskopi yapılan hastaların kolonoskopik ve patolojik sonuçlarının değerlendirilmesi. Akademik gastroenteroloji dergisi 2018;17:17-20.
  • Lee JH, Hong SP, Jeon TJ, et al. Should a colonoscopy be recommended for healthy individuals with increased carcinoembryonic antigen levels? A case-control study. Dig Dis Sci 2011;56:2396-403.

Cerrahi Onkoloji Temelli Check-Up Programı ve Asemptomatik Patolojilerin Belirlenmesi

Year 2025, Volume: 6 Issue: 1, 36 - 44, 15.03.2025

Abstract

Giriş: Çalışmamızın amacı check-up amacıyla başvuran sağlıklı bireylerin bulgularını paylaşmak, check-up programlarının benign ve malign patolojilerin erken tanısındaki etkinliğini saptamaktır.

Yöntemler: Check-up programı dahilinde; tüm olgulara postero-anterior akciğer grafisi, tiroid ve batın ultrasonografisi yapılmıştır. Tüm kadın olgulara meme ultrasonografisi ve 40 yaşından büyüklere mamografi uygulanmıştır. Hemogram ve rutin biyokimyasal testlerle birlikte gaytada gizli kan, karsinoembriyonik antijen ve erkeklerde prostat spesifik antijen testi yapıldı. Radyolojik görüntüler ve raporlar retrospektif olarak tarandı, laboratuvar sonuçlarından ise gaytada gizli kan, karsinoembriyonik antijen ve erkeklerde prostat spesifik antijen testi değerleri incelendi. Meme radyolojisinde meme görüntüleme raporlama ve veri sistemi (BIRADS), tiroid radyolojisinde tiroid görüntüleme raporlama ve veri sistemi (TIRADS) sistemi kullanılarak sınıflandırma yapıldı. Batın ultrasonografi bulguları organ spesifik olarak ayrı ayrı değerlendirildi.

Bulgular: Çalışmaya 1411 olgu dahil edildi. Olguların %49,4’ü kadın, %50,6’sı ise erkek, median yaş 50 idi. Olguların %5,31’inde karaciğerde benign lezyon, %4,7’sinde böbrek taşı, %5,7’sinde kolelitiyazis, kadın olguların %2,72’sinde benign jinekolojik kitle tespit edildi. Erkeklerin %20’sinde benign prostat hiperplazisi görüldü. %3,8’inde tiroid bezinde malignite şüpheli nodül görüldü ve biyopsi önerildi. Meme Ultrasonu yapılan olguların %0,28’inde, mamografi yapılanların ise %0,8’inde malignite şüpheli lezyon saptandı ve biyopsi önerildi. Olguların hepsine akciğer grafisi çekildi. %75,4’ünde normal, %22’sinde minör, %2,6’sında ise majör akciğer parankim bulguları saptandı ve bu olgulara toraks bilgisayarlı tomografisi ile ileri tetkik önerildi.

Sonuç: Çalışmadaki sonuçlarımıza göre; etkin check-up programları benign lezyonlarda tanı ve takibi sağladığından, malign veya premalign lezyonlarda ise erken tanı ve tedavi şansı sunduğundan toplum sağlığı açısından yararlı bulunmuştur.

References

  • Diaz Hernandez L, Giezendanner S, Fischer R, Zeller A. Expectations about check-up examinations among Swiss residents: A nationwide population-based cross-sectional survey. PLoS One 2021;16:e0254700.
  • Krogsbøll LT, Jørgensen KJ, Gøtzsche PC. General health checks in adults for reducing morbidity and mortality from disease. Cochrane Database Syst Rev 2019; 31;1:CD009009.
  • Sickles EA, D’Orsi CJ, Bassett LW, et al. ACR BI-RADS Mammography. In: ACR BI-RADS Atlas, Breast Imaging Reporting and Data System, 5th Edition, American College of Radiology 2013;134-36.
  • Orel SG, Kay N, Reynolds C, Sullivan DC. BI-RADS categorization as a predictor of malignancy. Radiology 1999;211:845-50.
  • Tessler FN, Middleton WD, Grant EG, et al. ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS committee. Journal of the American College of Radiology 2017;14:587–95.
  • Modi L, Sun W, Shafizadeh N, et al. Does a higher American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI‐RADS) score forecast an increased risk of malignancy? A correlation study of ACR TI‐RADS with FNA cytology in the evaluation of thyroid nodules. Cancer Cytopathology 2020;128:470-81.
  • Singaporewalla RM, Hwee J, Lang TU, Desai V. Clinico-pathological Correlation of Thyroid Nodule Ultrasound and Cytology Using the TIRADS and Bethesda Classifications. World J Surg 2017;41:1807-11.
  • Kim J, Kim KH. Role of chest radiographs in early lung cancer detection. Transl Lung Cancer Res 2020;9:522–31.
  • Okaniwa S, Hirai T, Ogawa M, et al. Working Group on Revision of the Manual for Abdominal Ultrasound in Cancer Screening and Health Checkups, Ultrasound Screening Committee of the Japanese Society of Gastrointestinal Cancer Screening. J Med Ultrason 2023;50:45–9.
  • Wang F, Numata K, Nihonmatsu H, Okada M, Maeda S. Application of new ultrasound techniques for focal liver lesion. J Med Ultrason 2020;47:215-37.
  • Hernaez R, Lazo M, Bonekamp S, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011;54:1082–90.
  • Popescu A, Sporea I. Ultrasound examination of normal gall bladder and biliary system. Med Ultrason 2010;12:150-2.
  • Nicolau C, Antunes N, Paño B, Sebastia C. Imaging Characterization of Renal Masses. Medicina (Kaunas) 2021;51:57.
  • Sherlock M, Scarsbrook A, Abbas A, et al. Adrenal Incidentaloma. Endocr Rev 2020; 41:775–820.
  • Yeşilkaya Y, Akata D. Kadın genital sistemin sonografik değerlendirilmesi. Türkiye Klinikleri Radyoloji-Özel Konular 2010;3-1.
  • Sirli R, Sporea I. Ultrasound examination of the normal pancreas. Med Ultrason. 2010;12:62-5.
  • Ciaravino V, D'Onofrio M. Pancreatic Ultrasound: State of the Art. J Ultrasound Med 2019;38:1125-37.
  • Chen MJ, Huang MJ, Chang WH, et al. Ultrasonography of splenic abnormalities. World J Gastroenterol 2005;11:4061-66.
  • Wen YH, Chang PY, Hsu CM, Wang HY, Chiu CT, Lu JJ. Cancer screening through a multi-analyte serum biomarker panel during health check-up examinations: Results from a 12-year experience. Clinica chimica açta 2015;450:273-76.
  • Rosita L, Occifa GA. Analysis of Prostate Specific Antigen (PSA) level on Medical Check-up (MCU) Participants. Bali Medical Journal 2019;8:267-69.
  • Huang H, Rong Y, Wang M, et al. Analysis of gastroscopy results among healthy people undergoing a medical checkup: a retrospective study. BMC gastroenterology 2020;20:1-9.
  • Vleugels JL, Van Lanschot MC, Dekker E. (2016). Colorectal cancer screening by colonoscopy: putting it into perspective. Digestive Endoscopy 2016;28:250-59.
  • Mizuma Y, Watanabe Y, Ozasa K, et al. Validity of sonographic screening for the detection of abdominal cancers. Journal of clinical ultrasound 2002;30:408-15.
  • Portincasa P, Moschetta A, Petruzzelli M, Palasciano G, Di Ciaula A, Pezzolla A. Gallstone disease: Symptoms and diagnosis of gallbladder stones. Best Pract Res Clin Gastroenterol 2006;20:1017-29.
  • Adem Y, Coşkun M, Turgut HT, Özyıldız M, Yazıcıoğlu MB, Yıldız SY. Ultrasonografide safra kesesinde polip saptanan hastaların postoperatif histopatolojik bulgularının analizi. Kocaeli Medical Journal 2016;5:1:11-5.
  • Serter S, Ceylan C, Tunçyürek Ö, Örgüç Ş, Pabuçcu Y. Sonographic evaluation of spleen size and prevalence of accessory spleen in a healthy male Turkish population. Turk J Haematol 2010;27:25-8.
  • Ciaravino V, D'Onofrio M. Pancreatic ultrasound: state of the art. Journal of Ultrasound in Medicine 2019;38:1125-37.
  • Liu YX, Wang JZ, Liu JP, Pang CK, Jia HY. Imaging diagnosis for fatty liver: a systematic review. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004;26:580-4.
  • İmamoğlu FG, İmamoğlu Ç, Çiledağ N, Arda K, Tola M, Düzgöl C. Karaciğer Yağlanmasının Ultrasonografi ile Sınıflandırılması ve Yağlanma Derecesinin Karaciğer Fonksiyon Testleri Üzerine Etkisinin İncelenmesi. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 2015;2:23-8.
  • Wanless IR. Benign liver tumors. Clin Liver Dis 2002;6:513-26.
  • Mortele KJ, Praet M, Van Vlierberghe H, Kunnen M, Ros PR. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic-pathologic correlation. AJR Am J Roentgenol 2000;175:687-92.
  • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020–22.
  • Walz PH, Bertermann H. Ultrasound examination of bladder and prostate. Urol Int. 1990;45:217-30.
  • Kang SK, Huang WC, Pandharipande PV, Chandarana H. Solid renal masses: What the numbers tell us. AJR Am. J. Roentgenol 2014;202:1196–1206.
  • Luczynska E, Zbigniew K. Diagnostic imaging in gynecology. Ginekologia Polska 2022;93:63-9.
  • Hoffman RM, Sanchez R. Lung Cancer Screening. Med Clin North Am 2017;101:769-85.
  • Obenauer S, Hermann KP, Grabbe E. Applications and literature review of the BI-RADS classification. European radiology 2005;15:1027-36.
  • Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European Thyroid Association guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults: the EU-TIRADS. European thyroid journal 2017;6:225-37.
  • Utku ÖG, Ergül B, Oğuz D. Gaitada gizli kan testi pozitifliği nedeni ile kolonoskopi yapılan hastaların kolonoskopik ve patolojik sonuçlarının değerlendirilmesi. Akademik gastroenteroloji dergisi 2018;17:17-20.
  • Lee JH, Hong SP, Jeon TJ, et al. Should a colonoscopy be recommended for healthy individuals with increased carcinoembryonic antigen levels? A case-control study. Dig Dis Sci 2011;56:2396-403.
There are 40 citations in total.

Details

Primary Language English
Subjects Oncologic Surgery, Cancer Diagnosis
Journal Section Research Articles
Authors

Kağan Gökçe 0000-0003-4712-0512

Demet Doğan 0000-0003-0792-9042

Publication Date March 15, 2025
Submission Date December 30, 2024
Acceptance Date February 9, 2025
Published in Issue Year 2025 Volume: 6 Issue: 1

Cite

APA Gökçe, K., & Doğan, D. (2025). Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies. Eskisehir Medical Journal, 6(1), 36-44.
AMA Gökçe K, Doğan D. Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies. Eskisehir Med J. March 2025;6(1):36-44.
Chicago Gökçe, Kağan, and Demet Doğan. “Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies”. Eskisehir Medical Journal 6, no. 1 (March 2025): 36-44.
EndNote Gökçe K, Doğan D (March 1, 2025) Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies. Eskisehir Medical Journal 6 1 36–44.
IEEE K. Gökçe and D. Doğan, “Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies”, Eskisehir Med J, vol. 6, no. 1, pp. 36–44, 2025.
ISNAD Gökçe, Kağan - Doğan, Demet. “Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies”. Eskisehir Medical Journal 6/1 (March 2025), 36-44.
JAMA Gökçe K, Doğan D. Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies. Eskisehir Med J. 2025;6:36–44.
MLA Gökçe, Kağan and Demet Doğan. “Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies”. Eskisehir Medical Journal, vol. 6, no. 1, 2025, pp. 36-44.
Vancouver Gökçe K, Doğan D. Surgical Oncology-Based Check-Up Program and Determining of Asymptomatic Pathologies. Eskisehir Med J. 2025;6(1):36-44.