HaNDL Syndrome: A rare and overlooked disease

Year 2025, Volume: 6 Issue: 2, 112 - 114, 28.07.2025

İlkin İyigündoğdu , Eda Derle

Abstract

Transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) syndrome is a rare and misdiagnosed condition characterized with temporary neurological deficits, headache and pleocytosis in cerebrospinal fluid (CSF). Symptoms vary widely in patients and many neurological diseases such as stroke, migraine, encephalitis and epilepsy should be considered in the differential diagnosis. In this report, we described a 41-year-old female patient with HaNDL syndrome presenting with dysphasia and headache and we aimed to highlight the disease by discussing the clinical features, management and follow up period of the disease. It is important to raise awareness of its existence to avoid unnecessary and potentially harmful research and treatments.

Keywords

HaNDL Syndrome , headache , lymphocytosis , pseudomigraine

HaNDL Sendromu: Nadir ve göz ardı edilen bir hastalık

Abstract

Beyin omurilik sıvısı lenfositozu ve geçici nörolojik bulguların eşlik ettiği baş ağrısı (HaNDL) sendromu, geçici nörolojik defisitler, baş ağrısı ve serebrospinal sıvıda (BOS) pleositoz ile karakterize nadir ve tanıda karışıklıklara neden olabilecek bir hastalıktır. Semptomlar hastalarda büyük ölçüde değişkenlik gösterir ve inme, migren, ensefalit ve epilepsi gibi birçok nörolojik hastalık ayırıcı tanıda düşünülmelidir. Bu raporda, konuşma bozukluğu ve baş ağrısı ile başvuran HaNDL sendromlu 41 yaşında bir kadın hastada hastalığın klinik özelliklerini, yönetimini ve takip sürecini tartışarak hastalığı vurgulamayı amaçladık. Hastalığın varlığı üzerine farkındalık gelişmesi ile gereksiz ve zararlı olabilecek araştırmalar ve tedavilerden kaçınılması önem taşımaktadır.

Keywords

HaNDL Sendromu , başağrısı , lenfositoz , psödomigren

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