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THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS

Year 2025, Volume: 6 Issue: 3, 225 - 229, 25.11.2025

Abstract

Introduction: This study aimed to investigate the relationship between left ventricular ejection fraction (LVEF) measured on preoperative transthoracic echocardiography (TTE) and peak systolic velocity (PSH) and resistance index (DI) calculated on postoperative renal Doppler ultrasonography.

Methods: The study retrospectively included 68 renal transplant patients. TTE measurements were taken for all patients, and LVEF was recorded. Renal Doppler ultrasonography recorded PSH and DI. Patients were divided into two groups based on LVEF below 55% (group 1, n=24) and above (group 2, n=44).

Results: Of the patients participating in our study, 21 (30.8%) were female and 47 (69.2%) were male. The mean age of the patients in the study was 53.2±9.27 years. Urea was significantly lower in patients with LVEF values above 55% (85.9±31.5 vs. 103.3±35.2; p=0.02). On the other hand, PSV and RI were significantly lower in the group with LVEF values above 55% (188.2±33.1 vs. 238.7±40.2; p=0.02; 0.64±0.15 vs. 0.78±0.19; p=0.04, respectively). A negative correlation was also found between LVEF values and PSV and RI (r= -0.731, p=0.007; r= -0.602, p=0.01, respectively).

Conclusion: In this study, renal transplant patients with echocardiographic LVEF greater than 55% had significantly lower RI and PSV determined by renal Doppler ultrasonography.

Ethical Statement

Approval for the study was obtained from Canakkale 18 Mart University Clinical Research Ethics Committee (protocol number: 2019/14, date: 24.07.2019).

Supporting Institution

none

Thanks

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References

  • Romagnani P, Agarwal R, Chan JCN, et al. Chronic kidney disease. Nat Rev Dis Primers 2025;11(1):8.
  • Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease – a systematic review and meta-analysis. PLoS One 2016;11(7):e0158765.
  • Luyckx VA, Tonelli M, Stanifer JW. The global burden of kidney disease and the sustainable development goals. Bull World Health Organ 2018;96(6):414-22.
  • Jager KJ, Kovesdy CP, Langham R, Rosenberg M, Jha V, Zoccali C. Epidemiology of chronic kidney disease: an update 2022. Nat Rev Nephrol 2022;18(5):277-88.
  • Francis A, Harhay MN, Ong ACM, et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol 2024;20(7):473-85.
  • Chadban SJ, Clayton PA, McDonald SP, et al. Survival after kidney transplantation compared with ongoing dialysis in matched elderly patients: A registry study. Am J Transplant 2023;23(10):1234-45.
  • Sarhan AL, Jarareh RH, Shraim M. Quality of life for kidney transplant recipients and hemodialysis patients in Palestine: a cross-sectional study. BMC Nephrol 2021;22(1):210. https://doi.org/10.1186/s12882-021-02412-z
  • Sarnak MJ, Amdur RL, Kausz AT. Cardiovascular disease in chronic kidney disease: a review of the evidence. Nephrol Dial Transplant 2013;28 Suppl 4:iv1-iv8.
  • Aljaroudi W, Alraies MC, Halley C, et al. Role of echocardiography in the management of patients with chronic kidney disease. J Am Heart Assoc 2019;8(18):e013784.
  • Wang LW, Masson P, Turner RM, et al. Prognostic value of cardiac tests in potential kidney transplant recipients: a meta-analysis. Am J Kidney Dis 2015;66(6):987-1001.
  • Radermacher J, Mengel M, Ellis S, et al. The use of Doppler ultrasonography to predict the outcome of renal transplantation. N Engl J Med 2003;344(17):1175-80.
  • Patel U, Khaw KK, Hughes NC. Doppler ultrasound for detection of renal transplant artery stenosis-threshold peak systolic velocity needs to be higher in a low-risk or surveillance population. Clin Radiol 2003;58(10):772-7.
  • Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022;145(18):e895-e1032.
  • Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015;28(1):1-39.e14.
  • Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr 2019;32(1):1-64.
  • Wilson DJ, North N, Wilson RA. Comparison of Left Ventricular Ejection Fraction Calculation Methods. Echocardiography 1998;15(8 Pt 1):709-12.
  • Azzouz S, Chen A, Ekmekjian T, Cantarovich M, Baran D, Sandal S. The role of renal resistive index as a prognostic tool in kidney transplantation: a systematic review. Nephrol Dial Transplant 2022;37(8):1552-65.
  • Jesrani AK, Faiq SM, Rashid R, et al. Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction. World J Transplant 2024;14(1):89255.
  • Geraci G, Ferrara P, La Via L, et al. Renal Resistive Index from Renal Hemodynamics to Cardiovascular Risk: Diagnostic, Prognostic, and Therapeutic Implications. Diseases 2025;13(6):178.
  • Spatola L, Andrulli S. Doppler ultrasound in kidney diseases: a key parameter in clinical long-term follow-up. J Ultrasound 2016;19(4):243-50.
  • Bahl A, Prasad N, Sinha DP, et al. Cardiac evaluation in patients awaiting kidney transplant-position statement of the Cardiological Society of India and Indian Society of Nephrology. Indian Heart J 2025;77(3):204-12.
  • Wang HK, Chiou SY, Lai YC, et al. Early postoperative spectral Doppler parameters of renal transplants: the effect of donor and recipient factors. Transplant Proc 2012;44(1):226-9.
  • Weston MJ. Doppler ultrasound for detection of renal transplant artery stenosis-threshold peak systolic velocity needs to be higher in a low-risk or surveillance population. Clin Radiol 2003;58(10):770-1.

RENAL TRANSPLANTASYON YAPILAN HASTALARDA KARDİYAK FONKSİYON İLE RENAL KAN AKIMI ARASINDAKİ İLİŞKİ

Year 2025, Volume: 6 Issue: 3, 225 - 229, 25.11.2025

Abstract

Giriş: Bu çalışma preoperatif transtorasik ekokardiyografide (TTE) ölçülen sol ventrikül ejeksiyon fraksiyonu (SVEF) ile postoperatif renal Doppler ultrasonografide hesaplanan tepe sistolik hız (TSH) ve direnç indeksi (DI) arasındaki ilişkiyi incelemeyi hedeflemiştir.

Yöntemler: Çalışmaya retrospektif olarak 68 renal transplantasyon yapılan hasta dahil edildi. Tüm hastaların TTE ölçümleri alındı SVEF kayıt edildi. Renal Doppler ultrasonografide TSH ve DI’leri not edildi. Hastalar SVEF % 55’in altında (grup 1, n=24) ve üstünde (grup 2, n=44) olmalarına göre iki gruba ayrıldı.

Bulgular: Bizim yaptığımız bu çalışmaya katılan hastaların 21'i (%30,8) kadın 47'si (%69,2) erkekti. Çalışmadaki hastaların ortalama yaşı 53,2±9,27 idi. SVEF değerleri %55'in üzerinde olan hastalarda üre anlamlı derecede düşüktü (85,9±31,5'e karşı 103,3±35,2; p=0,02). Öte yandan, SVEF değerleri %55'in üzerinde olan grupta TSH ve DI anlamlı derecede düşüktü (sırasıyla 188,2±33,1'e karşı 238,7±40,2; p=0,02; 0,64±0,15'e karşı 0,78±0,19, p=0,04). LVEF değerleri ile TSH ve DI arasında negatif korelasyon da bulundu (sırasıyla r= -0,731, p=0,007; r= -0,602, p=0,01).

Sonuç: Bu çalışmada, ekokardiyografik SVEF'si %55'ten büyük olan renal transplantasyon yapılan hastaların renal Doppler ultrasonografi ile belirlenen DI ve TSH anlamlı derecede düşük olarak bulunmuştur.

Ethical Statement

Çalışma için Çanakkale 18 Mart Üniversitesi Klinik Araştırmalar Etik Kurulu’ndan onay alındı ​​(protokol numarası: 2019/14, tarih: 24.07.2019).

Supporting Institution

yok

Thanks

-

References

  • Romagnani P, Agarwal R, Chan JCN, et al. Chronic kidney disease. Nat Rev Dis Primers 2025;11(1):8.
  • Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease – a systematic review and meta-analysis. PLoS One 2016;11(7):e0158765.
  • Luyckx VA, Tonelli M, Stanifer JW. The global burden of kidney disease and the sustainable development goals. Bull World Health Organ 2018;96(6):414-22.
  • Jager KJ, Kovesdy CP, Langham R, Rosenberg M, Jha V, Zoccali C. Epidemiology of chronic kidney disease: an update 2022. Nat Rev Nephrol 2022;18(5):277-88.
  • Francis A, Harhay MN, Ong ACM, et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol 2024;20(7):473-85.
  • Chadban SJ, Clayton PA, McDonald SP, et al. Survival after kidney transplantation compared with ongoing dialysis in matched elderly patients: A registry study. Am J Transplant 2023;23(10):1234-45.
  • Sarhan AL, Jarareh RH, Shraim M. Quality of life for kidney transplant recipients and hemodialysis patients in Palestine: a cross-sectional study. BMC Nephrol 2021;22(1):210. https://doi.org/10.1186/s12882-021-02412-z
  • Sarnak MJ, Amdur RL, Kausz AT. Cardiovascular disease in chronic kidney disease: a review of the evidence. Nephrol Dial Transplant 2013;28 Suppl 4:iv1-iv8.
  • Aljaroudi W, Alraies MC, Halley C, et al. Role of echocardiography in the management of patients with chronic kidney disease. J Am Heart Assoc 2019;8(18):e013784.
  • Wang LW, Masson P, Turner RM, et al. Prognostic value of cardiac tests in potential kidney transplant recipients: a meta-analysis. Am J Kidney Dis 2015;66(6):987-1001.
  • Radermacher J, Mengel M, Ellis S, et al. The use of Doppler ultrasonography to predict the outcome of renal transplantation. N Engl J Med 2003;344(17):1175-80.
  • Patel U, Khaw KK, Hughes NC. Doppler ultrasound for detection of renal transplant artery stenosis-threshold peak systolic velocity needs to be higher in a low-risk or surveillance population. Clin Radiol 2003;58(10):772-7.
  • Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022;145(18):e895-e1032.
  • Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015;28(1):1-39.e14.
  • Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr 2019;32(1):1-64.
  • Wilson DJ, North N, Wilson RA. Comparison of Left Ventricular Ejection Fraction Calculation Methods. Echocardiography 1998;15(8 Pt 1):709-12.
  • Azzouz S, Chen A, Ekmekjian T, Cantarovich M, Baran D, Sandal S. The role of renal resistive index as a prognostic tool in kidney transplantation: a systematic review. Nephrol Dial Transplant 2022;37(8):1552-65.
  • Jesrani AK, Faiq SM, Rashid R, et al. Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction. World J Transplant 2024;14(1):89255.
  • Geraci G, Ferrara P, La Via L, et al. Renal Resistive Index from Renal Hemodynamics to Cardiovascular Risk: Diagnostic, Prognostic, and Therapeutic Implications. Diseases 2025;13(6):178.
  • Spatola L, Andrulli S. Doppler ultrasound in kidney diseases: a key parameter in clinical long-term follow-up. J Ultrasound 2016;19(4):243-50.
  • Bahl A, Prasad N, Sinha DP, et al. Cardiac evaluation in patients awaiting kidney transplant-position statement of the Cardiological Society of India and Indian Society of Nephrology. Indian Heart J 2025;77(3):204-12.
  • Wang HK, Chiou SY, Lai YC, et al. Early postoperative spectral Doppler parameters of renal transplants: the effect of donor and recipient factors. Transplant Proc 2012;44(1):226-9.
  • Weston MJ. Doppler ultrasound for detection of renal transplant artery stenosis-threshold peak systolic velocity needs to be higher in a low-risk or surveillance population. Clin Radiol 2003;58(10):770-1.
There are 23 citations in total.

Details

Primary Language English
Subjects Cardiology
Journal Section Research Article
Authors

Ercan Akşit 0000-0002-4478-4324

Hasan Anıl Kurt 0000-0001-7292-2248

Mehmet Arslan 0000-0001-8785-7944

Hüseyin Uğur Özkaya 0000-0001-7311-5739

Publication Date November 25, 2025
Submission Date September 2, 2025
Acceptance Date October 20, 2025
Published in Issue Year 2025 Volume: 6 Issue: 3

Cite

APA Akşit, E., Kurt, H. A., Arslan, M., Özkaya, H. U. (2025). THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS. Eskisehir Medical Journal, 6(3), 225-229.
AMA Akşit E, Kurt HA, Arslan M, Özkaya HU. THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS. Eskisehir Med J. November 2025;6(3):225-229.
Chicago Akşit, Ercan, Hasan Anıl Kurt, Mehmet Arslan, and Hüseyin Uğur Özkaya. “THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS”. Eskisehir Medical Journal 6, no. 3 (November 2025): 225-29.
EndNote Akşit E, Kurt HA, Arslan M, Özkaya HU (November 1, 2025) THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS. Eskisehir Medical Journal 6 3 225–229.
IEEE E. Akşit, H. A. Kurt, M. Arslan, and H. U. Özkaya, “THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS”, Eskisehir Med J, vol. 6, no. 3, pp. 225–229, 2025.
ISNAD Akşit, Ercan et al. “THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS”. Eskisehir Medical Journal 6/3 (November2025), 225-229.
JAMA Akşit E, Kurt HA, Arslan M, Özkaya HU. THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS. Eskisehir Med J. 2025;6:225–229.
MLA Akşit, Ercan et al. “THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS”. Eskisehir Medical Journal, vol. 6, no. 3, 2025, pp. 225-9.
Vancouver Akşit E, Kurt HA, Arslan M, Özkaya HU. THE RELATIONSHIP BETWEEN HEART FUNCTION AND RENAL BLOOD FLOW IN RENAL TRANSPLANT PATIENTS. Eskisehir Med J. 2025;6(3):225-9.