B12 EKSİKLİĞİ İLE KARDİYOVASKÜLER RİSK ARASINDAKİ İLİŞKİNİN SCORE İLE DEĞERLENDİRİLMESİ

Year 2025, Volume: 6 Issue: 3, 269 - 273, 25.11.2025

Latife Uzun , Aslı Melek Zeytin

Abstract

Giriş: SCORE (Systematic COronary Risk Evaluation) Türkiye, 10 yıllık kardiyovasküler ölüm riskini değerlendirmede kullanılan bir risk hesaplama aracıdır. Bu çalışma, vitamin B12 düzeyinin SCORE Türkiye ölçeği ile belirlenen kardiyovasküler risk ile ilişkisini araştırmayı amaçlamaktadır.

Yöntemler: Bu çalışma 1 Nisan 2023 ile 31 Mart 2025 tarihleri arasında Karaman 56 No’lu Aile Hekimliği Birimi’ne başvuran 40-65 yaş aralığındaki bireylerde retrospektif olarak yapılmıştır. Yaş, cinsiyet, sigara kullanım durumu, kan basıncı, serum vitamin B12 ve total kolesterol düzeyleri kullanılarak SCORE Türkiye ölçeği aracılığıyla kardiyovasküler hastalık gelişme risk puanı hesaplanmıştır.

Bulgular: Çalışmaya katılan bireylerin %16,9’unda B12 vitamini eksikliği, %45,4’ünde yetersizliği görülmüştür. Vitamin B12 eksikliği ve yetersizliği olanlarda cinsiyet, kan basıncı, total kolesterol düzeyi ve sigara kullanım durumu açısından anlamlı farklılık tespit edilmemiştir. SCORE risk puanı, erkeklerde anlamlı olarak yüksek bulunmuştur. Yüksek ve çok yüksek riskli olan grubun %66,7’sinde; orta riskli grubun %62,4’ünde vitamin B12 eksikliği ve yetersizliği tespit edilmiştir. Ancak istatistiksel olarak anlamlı bir fark görülmemiştir.

Sonuç: İstatistiksel anlamlılık elde edilmemiş olsa da her iki grupta da yüksek oranlarda B12 eksikliği ve yetersizliği tespit edilmiştir. Sonuçlar vitamin B12’nin homosistein aracılığıyla endotel fonksiyonlarını olumsuz etkileyerek kardiyovasküler risk değerlendirmelerine dahil edilebilecek önemli bir parametre olabileceğini ancak daha fazla kanıta ihtiyaç duyulduğunu göstermektedir.

Keywords

VİTAMİN B12 , KARDİYOVASKÜLER RİSK , SCORE TÜRKİYE ÖLÇEĞİ

Ethical Statement

Karamanoğlu Mehmetbey Üniversitesi Tıp Fakültesi'nden 09.04.2025 tarihli 18- 2025/07 sayılı Etik Kurul onayı alınmıştır.

Supporting Institution

Finansal destekleyen kurum yoktur.

Thanks

Teşekkür açıklaması yoktur.

ASSESSMENT OF THE RELATIONSHIP BETWEEN VITAMIN B12 DEFICIENCY AND CARDIOVASCULAR RISK USING THE SCORE

Abstract

Introduction: SCORE (Systematic COronary Risk Evaluation) is a cardiovascular risk assessment tool used to estimate the 10-year risk of cardiovascular mortality. This study aims to investigate the relationship between serum vitamin B12 levels and cardiovascular risk as determined by the SCORE Türkiye scale.

Methods: This retrospective study was conducted among individuals aged 40-65 who presented to Karaman Family Medicine Unit No. 56 between 1 April 2023 and 31 March 2025. Cardiovascular risk scores were calculated using SCORE scale based on age, sex, smoking status, blood pressure, serum vitamin B12 levels, and total cholesterol levels.

Results: Among the participants, 16.9% exhibited vitamin B12 deficiency, and 45.4% had insufficient levels. No statistically significant differences were observed between the participants with vitamin B12 deficiency and those with insufficiency in terms of sex, blood pressure, total cholesterol, or smoking status. Risk scores were significantly higher in the male participants. Vitamin B12 deficiency or insufficiency was identified in 66.7% of the high/very high-risk group and 62.4% of the moderate-risk group. However, these differences were not statistically significant.

Conclusion: Although statistical significance was not achieved, high rates of vitamin B12 deficiency and insufficiency were observed across all risk groups. These results suggested that vitamin B12 deficiency may negatively affect endothelial function via homocysteine pathways and could be considered a relevant parameter in cardiovascular risk assessments, pending further evidence

Keywords

VITAMIN B12 , CARDIOVASCULAR RISK , SCORE TÜRKİYE SCALE

Ethical Statement

Ethics Committee approval was received from Karamanoğlu Mehmetbey University Faculty of Medicine, dated 09.04.2025 and numbered 18-2025/07.

Supporting Institution

There is no financial support institution.

Thanks

There is no thank you statement.

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