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QUALITATIVE ANALYSIS OF DELAYED-CONCENTRATION IN OREGONATOR-BASED CHEMICAL OSCILLATORS

Year 2018, Volume: 19 Issue: 3, 637 - 644, 01.09.2018

Abstract

Beulosuv-Zhabotonksiy reaction is pure chemical reaction that exhibits sustained and relaxed oscillations, which are analgous to observed oscillations in many biological systems. The reaction is very complicated, however, its oscillatory mechanism is represented by a simple model, called the Oregonator. Since delays naturally appear in chemical reactions and they are often responsible for presence of complex behaviours, delay effects in Beulosuv-Zhabotonksiy reaction should be considered to better explain the mechanism of some biochemical oscillations. In this work, qualitative and asymptotic analysis of the Oregonator model by taking into account the delays arising due to the physical constraints will be considered. Some numerical results will given to present some certain properties of the considered model.

References

  • Niculescu, S. I. Delay Effects on Stability: A Robust Control Approach. London,U.K.: Springer-Verlag, 2001.
  • Bocharov, G. A., Rihan, F. A. Numerical modelling in biosciences using delay differential equations. Journal of Computational and Applied Mathematics 2000; 125(1:2): 183-199.
  • Roussel, M. R. The use of delay differential equations in chemical kinetics. The Journal of Physical Chemistry. 1996; 100: 8323-8330.
  • Feinberg, M. (1979). Lectures on Chemical Reaction Networks. [Online].Available: https://crnt.osu.edu/LecturesOnReactionNetworks
  • Chellaboina, V., Bhat, S.P., Haddad, M. and Bernstein, D.S. Modeling and Analysis of Mass-Action Kinetics. IEEE Control Systems 2009; 29: 60-78.
  • Epstein, I. R., Luo,Y. Differential Delay Equations in Chemical Kinetics. Nonlinear Models: The Cross-Shaped Phase diagram and the Oregonator. The Journal of Chemical Physics 1991; 95: 244-254.
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  • Murray, J.D. Mathematical Biology I: An Introduction. York, PA, USA: Springer Verlag, 2002.
  • Shanks, N. Modeling biological systems: The Belousov_Zhabotinsky reaction. Foundations of Chemistry 2001; 3(1): 33-53.
  • Goldbeter, A. Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour. Cambridge, U.K. Cambridge Univ. Press, 1997.
  • Novak B, Tyson, J.J. Design Principles of Biochemical oscillators. Nature Reviews Molecular Biology 2008; 9:891-991.
  • Goldbeter, A., Gerard, C., Donze, G., Leloup, J.-C., and Dupont, G. Systems biology of cellular rhythms. FEBS Letters 2012; 586: 2955-2965.
  • Goldbeter, A. Computational approaches to cellular rhythmes. Nature 2002; 420: 238-245.
  • Ünal, H. U., Boussaada, I., Niculescu, S.I. A Delay-Based Sustained Chemical Oscillator: Qualitative Analysis of Oregonator-Based Models. IEEE Life Science Letters 2017; 3: 9-12.
  • Wright, M. R. Fundamental Chemical Kinetics: An Explanatory Introduction to the Concepts. (1999) New York, NY, USA: Elsevier, 1999.
  • Churchill, R.V., Brown J.W. Complex Variables and Applications. 6th ed. Singapure: McGrawHill, 1996.
  • Micheils W., Niculescu, S.I. Stability, Control, and Computation for Time-Delay Systems: An Eigenvalue-Based Approach. 2nd revised ed. SIAM, 2014.
  • Vhylidal, T., Zitek, P. Quasipolynomial Root-finder: Algorithm Update and Example. In: Vhylidal, T., Lafay, J.F., Sipahi, R. editors. Advances in Delays and Dynamics. Springer Cham, 2013. pp. 299-311.
Year 2018, Volume: 19 Issue: 3, 637 - 644, 01.09.2018

Abstract

References

  • Niculescu, S. I. Delay Effects on Stability: A Robust Control Approach. London,U.K.: Springer-Verlag, 2001.
  • Bocharov, G. A., Rihan, F. A. Numerical modelling in biosciences using delay differential equations. Journal of Computational and Applied Mathematics 2000; 125(1:2): 183-199.
  • Roussel, M. R. The use of delay differential equations in chemical kinetics. The Journal of Physical Chemistry. 1996; 100: 8323-8330.
  • Feinberg, M. (1979). Lectures on Chemical Reaction Networks. [Online].Available: https://crnt.osu.edu/LecturesOnReactionNetworks
  • Chellaboina, V., Bhat, S.P., Haddad, M. and Bernstein, D.S. Modeling and Analysis of Mass-Action Kinetics. IEEE Control Systems 2009; 29: 60-78.
  • Epstein, I. R., Luo,Y. Differential Delay Equations in Chemical Kinetics. Nonlinear Models: The Cross-Shaped Phase diagram and the Oregonator. The Journal of Chemical Physics 1991; 95: 244-254.
  • Field, R.J, Noyes, R.M. Oscillations in Chemical Systems. IV. Limit cycle behavior in a model of a real chemical reaction. The Journal of Chemical Physics 1974; 60:1877-1884.
  • Murray, J.D. Mathematical Biology I: An Introduction. York, PA, USA: Springer Verlag, 2002.
  • Shanks, N. Modeling biological systems: The Belousov_Zhabotinsky reaction. Foundations of Chemistry 2001; 3(1): 33-53.
  • Goldbeter, A. Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour. Cambridge, U.K. Cambridge Univ. Press, 1997.
  • Novak B, Tyson, J.J. Design Principles of Biochemical oscillators. Nature Reviews Molecular Biology 2008; 9:891-991.
  • Goldbeter, A., Gerard, C., Donze, G., Leloup, J.-C., and Dupont, G. Systems biology of cellular rhythms. FEBS Letters 2012; 586: 2955-2965.
  • Goldbeter, A. Computational approaches to cellular rhythmes. Nature 2002; 420: 238-245.
  • Ünal, H. U., Boussaada, I., Niculescu, S.I. A Delay-Based Sustained Chemical Oscillator: Qualitative Analysis of Oregonator-Based Models. IEEE Life Science Letters 2017; 3: 9-12.
  • Wright, M. R. Fundamental Chemical Kinetics: An Explanatory Introduction to the Concepts. (1999) New York, NY, USA: Elsevier, 1999.
  • Churchill, R.V., Brown J.W. Complex Variables and Applications. 6th ed. Singapure: McGrawHill, 1996.
  • Micheils W., Niculescu, S.I. Stability, Control, and Computation for Time-Delay Systems: An Eigenvalue-Based Approach. 2nd revised ed. SIAM, 2014.
  • Vhylidal, T., Zitek, P. Quasipolynomial Root-finder: Algorithm Update and Example. In: Vhylidal, T., Lafay, J.F., Sipahi, R. editors. Advances in Delays and Dynamics. Springer Cham, 2013. pp. 299-311.
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Details

Journal Section Articles
Authors

Hakki Ulaş Ünal This is me

Publication Date September 1, 2018
Published in Issue Year 2018 Volume: 19 Issue: 3

Cite

AMA Ünal HU. QUALITATIVE ANALYSIS OF DELAYED-CONCENTRATION IN OREGONATOR-BASED CHEMICAL OSCILLATORS. Estuscience - Se. September 2018;19(3):637-644.