PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Year 2021, Volume: 22 Issue: 1, 10 - 22, 26.03.2021

Fatih Erdem Baştan

https://doi.org/10.18038/estubtda.674424

Abstract

In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a drug carrier system. The dissolution of the polymer in the physiological medium allows to release the drug in a controlled manner and also develop the cell-microsphere interactions. Gelatin functionalized HA microspheres and bare HA granules were produced by spray drying. The morphology, thermal properties, chemical and phase structure of the produced powders were analysed with SEM, TG-DTA, FTIR and XRD. HA-Gel microspheres presented spherical morphology and hollow/core-shell cross-section and included HA nanoparticles and gelatin together according to the SEM, FTIR and XRD studies. TG-DTA results showed that gelatin was evolved from the microspheres ~300 °C, and bare HA was stable up to 1400 °C. Gelatin was released from the microspheres after immersion in the phosphate buffer saline (PBS) solution for 14 days.

Keywords

Functionalized Hydroxyapatite, gelatin, spray drying

Supporting Institution

The Scientific and Technological Research Council of Turkey, TÜBİTAK

Project Number

1919B011801595

Thanks

The author would like to thank Sakarya University Thermal Spray Research and Development Laboratory, especially the head Prof. Fatih Üstel for providing the entire analyzing equipment. This work was partly supported by The Scientific and Technological Research Council of Turkey, TÜBİTAK (Project no: 1919B011801595) and the author would like to give gratitude to Mat. Eng. Hilmi Tunahan Eligül and Sergen Belit for their assistance on producing and characterization of HA/gelatin microspheres and Dr. Egemen Avcu for helping on writing process of the paper.

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Abstract

Project Number

1919B011801595

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