EFFICIENT DRUG CARRIER FOR ACETYLSALICYLIC ACID FROM CHITOSAN-BASED COMPOSITES PREPARED WITH MONTMORILLONITE, CELLULOSE AND HYDROXYAPATITE

Year 2024, Volume: 25 Issue: 3, 368 - 379, 30.09.2024

Dilay Sezer , Zeynep Aktaş , Seda Hoşgün , Emir Zafer Hoşgün , Berrin Bozan

https://doi.org/10.18038/estubtda.1428785

Abstract

In this study, chitosan-based hydroxyapatite/chitosan (HAP/CHI), cellulose/chitosan (CEL/CHI) and montmorillonite/chitosan (MMT/CHI) composites were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA). Acetylsalicylic acid (ASA) was used as a drug for loading and desorption studies to determine the release behavior of the synthesized composites. The maximum adsorption capacities (qe) were obtained as 251.5 mg/g, 197.7 mg/g and 288.95 mg/g for HAP/CHI, CEL/CHI and MMT/CHI, respectively. In vitro release studies of ASA from the composites HAP/CHI, CEL/CHI, and MMT/CHI were carried out phosphate buffer solution (PBS) and gastric juice (GJ). In the intestinal medium (PBS) controlled drug release continued for 72 hours (4320 minutes), and burst release was observed in the first 5 minutes in all composites. 19.16%, 47.15% and 37.32% of the active ingredient from HAP/CHI, CEL/CHI and MMT/CHI composites, respectively, were released in the first 5 minutes. After 5 minutes, the release slowed down and became more controlled for all three composites. At the end of the release, the highest releasing composite was CEL/CHI, with 95.77% ASA release. A total drug release of 87.48% was achieved with MMT/CHI and 87.37% with HAP/CHI. In the gastric environment (GJ) Controlled drug release continued for 72 hours (4320 minutes), and burst release was observed in the first 5 minutes in all composites. 52.51%, 72.30% and 44.87% of the active ingredient from HAP/CHI, CEL/CHI and MMT/CHI composites, respectively, were released in the first 5 minutes. After 5 minutes, the release slowed down and became more controlled for all three composites. At the end of the release, the highest releasing capacity was found with the CEL/CHI composite, with 96.05% ASA release. A total drug release of 93.26% was achieved with HAP/CHI and 84.89% with MMT/CHI.

Keywords

Chitosan, drug delivery, composite, acetylsalicylic acid, montmorillonite.

Ethical Statement

The author(s) stated that there are no conflicts of interest regarding the publication of this article.

Project Number

22ADP087

Thanks

This study was supported by Eskisehir Technical University Scientific Research Projects Commission under Grant No: 22ADP087

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