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PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM

Year 2019, Volume: 8 Issue: 2, 229 - 237, 31.07.2019
https://doi.org/10.18036/estubtdc.599094

Abstract

ABSTRACT



The current study was aimed to
determine phenolic compounds profile and antioxidant activity of 70% MeOH
extract of Teucrium cavernarum  P.H. Davis which is an endemic plant of
Turkey.



 



According to LC-MS/MS analysis
of the extract, forsythoside A, forsythoside B, luteolin-7-gucoside,
cirsimaritin and cirsiliol were determined as the major compounds. The total
phenolic and radical scavenging activities of the extract were also determined.
According to antioxidant activity results, IC50 value of
1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect was determined
as 0.12 ±0.01 mg/mL. 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)
(ABTS) radical scavenging activity was also determined as 1.2 mM trolox
equivalent (TEAC).



References

  • [1] Baytop T. Türkiyede Bitkiler ile Tedavi Geçmişte ve Bugün. 2nd ed. İstanbul, Turkey: İstanbul Üniversitesi Publication, 1999.
  • [2] Nematollahi-Mahani SN, Rezazadeh-Kermani M, Mehrabani M,Nakhaee N. Cytotoxic Effects of Teucrium polium. on Some Established Cell Lines. Pharm Biol 2007; 45: 295-298.
  • [3] Ozgen U, Mavi A, Terzi Z, Yιldιrιm A, Coşkun M, Houghton PJ. Antioxidant Properties of Some Medicinal Lamiaceae Labiatae Species. Pharm Biol 2006; 44: 107-112,
  • [4] Sıngleton V.L, Orthofer R, Lamuela-Ravento´S RM. Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent, In: Packer L, editor. Methods in Enzymology. San Diego, USA: Academic Press 1999. Pp. 152-178
  • [5] Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, Lamari FN. Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J. Agric. Food Chem 2006; 54: 8762-8768.
  • [6] Kumarasamy Y, Byres M, Cox PJ, Jaspars M, Nahar L, Sarker SD. Screening seeds of some Scottish plants for free radical scavenging activity. Phytother Res 2007; 21: 615-621.
  • [7] Clifford MN, Johnston KL, Knight S, Kuhnert N.. Hierarchical scheme for LC-MS Identification of chlorogenic acids. J. Agric. Food Chem 2003; 51: 2900-2911.
  • [8] Mitreski I, Stanoeva JP, Stefova M, Stefkov G, Kulevanova S. 2014. Polyphenols in Representative Teucrium Species in the Flora of R. Macedonia: LC/DAD/ESI-MSn Profile and Content. Nat Prod Commun 2014; 9: 175-180
  • [9] Parejo I, Jauregui O, Sanchez-Rabaneda F, Viladomat F, Bastida J, Codina C. (2004) Separation and characterization of phenolic compounds in fennel (Foeniculum vulgare) using liquid chromatography-negative electrospray ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 52, 3679-3687.
  • [10]. Sánchez-Rabaneda F, Jáuregui O, Lamuela-Raventós RM, Bastida J, Viladomat F, Codina C. Identification of phenolic compounds in artichoke waste by high-performance liquid chromatography–tandem mass spectrometry. J. Chromatogr. A 2003; 1008: 57-72.
  • [11] Tepe B, Degerli S, Arslan S, Malatyali E, Sarikurkcu C. Determination of chemical profile, antioxidant, DNA damage protection and antiamoebic activities of Teucrium polium and Stachys iberica. Fitoterapia 2011; 82: 237-246.
  • [12] Ozkan G, Kuleasan H, Celik S, Gokturk RS, Unal, O,. Screening of Turkish endemic Teucrium montbretii subsp pamphylicum extracts for antioxidant and antibacterial activities, Food Control 2007; 18: 509-512.
  • [13] Kaya A, Demirci B, Dinc M, Dogu S, Baser KHC, 2013. Compositions of the Essential Oils of Teucrium cavernarum and Teucrium paederotoides, Two Endemic Species from Turkey. J Essent Oil Bear Pl 2013;16, 588-594.
Year 2019, Volume: 8 Issue: 2, 229 - 237, 31.07.2019
https://doi.org/10.18036/estubtdc.599094

Abstract

References

  • [1] Baytop T. Türkiyede Bitkiler ile Tedavi Geçmişte ve Bugün. 2nd ed. İstanbul, Turkey: İstanbul Üniversitesi Publication, 1999.
  • [2] Nematollahi-Mahani SN, Rezazadeh-Kermani M, Mehrabani M,Nakhaee N. Cytotoxic Effects of Teucrium polium. on Some Established Cell Lines. Pharm Biol 2007; 45: 295-298.
  • [3] Ozgen U, Mavi A, Terzi Z, Yιldιrιm A, Coşkun M, Houghton PJ. Antioxidant Properties of Some Medicinal Lamiaceae Labiatae Species. Pharm Biol 2006; 44: 107-112,
  • [4] Sıngleton V.L, Orthofer R, Lamuela-Ravento´S RM. Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent, In: Packer L, editor. Methods in Enzymology. San Diego, USA: Academic Press 1999. Pp. 152-178
  • [5] Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, Lamari FN. Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J. Agric. Food Chem 2006; 54: 8762-8768.
  • [6] Kumarasamy Y, Byres M, Cox PJ, Jaspars M, Nahar L, Sarker SD. Screening seeds of some Scottish plants for free radical scavenging activity. Phytother Res 2007; 21: 615-621.
  • [7] Clifford MN, Johnston KL, Knight S, Kuhnert N.. Hierarchical scheme for LC-MS Identification of chlorogenic acids. J. Agric. Food Chem 2003; 51: 2900-2911.
  • [8] Mitreski I, Stanoeva JP, Stefova M, Stefkov G, Kulevanova S. 2014. Polyphenols in Representative Teucrium Species in the Flora of R. Macedonia: LC/DAD/ESI-MSn Profile and Content. Nat Prod Commun 2014; 9: 175-180
  • [9] Parejo I, Jauregui O, Sanchez-Rabaneda F, Viladomat F, Bastida J, Codina C. (2004) Separation and characterization of phenolic compounds in fennel (Foeniculum vulgare) using liquid chromatography-negative electrospray ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 52, 3679-3687.
  • [10]. Sánchez-Rabaneda F, Jáuregui O, Lamuela-Raventós RM, Bastida J, Viladomat F, Codina C. Identification of phenolic compounds in artichoke waste by high-performance liquid chromatography–tandem mass spectrometry. J. Chromatogr. A 2003; 1008: 57-72.
  • [11] Tepe B, Degerli S, Arslan S, Malatyali E, Sarikurkcu C. Determination of chemical profile, antioxidant, DNA damage protection and antiamoebic activities of Teucrium polium and Stachys iberica. Fitoterapia 2011; 82: 237-246.
  • [12] Ozkan G, Kuleasan H, Celik S, Gokturk RS, Unal, O,. Screening of Turkish endemic Teucrium montbretii subsp pamphylicum extracts for antioxidant and antibacterial activities, Food Control 2007; 18: 509-512.
  • [13] Kaya A, Demirci B, Dinc M, Dogu S, Baser KHC, 2013. Compositions of the Essential Oils of Teucrium cavernarum and Teucrium paederotoides, Two Endemic Species from Turkey. J Essent Oil Bear Pl 2013;16, 588-594.
There are 13 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Articles
Authors

Fatih Göğer 0000-0002-9665-0256

Ayla Kaya This is me 0000-0002-7598-7132

Muhittin Dinç 0000-0001-7287-9817

Süleyman Doğu Doğu 0000-0002-5352-9288

Publication Date July 31, 2019
Published in Issue Year 2019 Volume: 8 Issue: 2

Cite

APA Göğer, F., Kaya, A., Dinç, M., Doğu, S. D. (2019). PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, 8(2), 229-237. https://doi.org/10.18036/estubtdc.599094
AMA Göğer F, Kaya A, Dinç M, Doğu SD. PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji. July 2019;8(2):229-237. doi:10.18036/estubtdc.599094
Chicago Göğer, Fatih, Ayla Kaya, Muhittin Dinç, and Süleyman Doğu Doğu. “PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM”. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 8, no. 2 (July 2019): 229-37. https://doi.org/10.18036/estubtdc.599094.
EndNote Göğer F, Kaya A, Dinç M, Doğu SD (July 1, 2019) PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 8 2 229–237.
IEEE F. Göğer, A. Kaya, M. Dinç, and S. D. Doğu, “PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM”, Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, vol. 8, no. 2, pp. 229–237, 2019, doi: 10.18036/estubtdc.599094.
ISNAD Göğer, Fatih et al. “PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM”. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji 8/2 (July 2019), 229-237. https://doi.org/10.18036/estubtdc.599094.
JAMA Göğer F, Kaya A, Dinç M, Doğu SD. PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji. 2019;8:229–237.
MLA Göğer, Fatih et al. “PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM”. Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji, vol. 8, no. 2, 2019, pp. 229-37, doi:10.18036/estubtdc.599094.
Vancouver Göğer F, Kaya A, Dinç M, Doğu SD. PHENOLIC COMPOUNDS DETERMINATION AND ANTIOXIDANT ACTIVITY OF TEUCRIUM CAVERNARUM. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji. 2019;8(2):229-37.