Coenzyme Q10: Current Overview

Kadriye Erdoğan; Melahat Sedanur Macit; Nazlı Tunca Şanlıer; Yaprak Ustun

doi:10.46969/EZH.1002286

Review

Coenzyme Q10: Current Overview

Year 2022, , 77 - 86, 30.06.2022

Kadriye Erdoğan , Melahat Sedanur Macit , Nazlı Tunca Şanlıer Yaprak Ustun

https://doi.org/10.46969/EZH.1002286

Abstract

Coenzyme Q10 (CoQ10) is a lipid-soluble component from benzoquinones. The oxidized form of Coenzyme Q10 is ubiquinone, and the reduced form is ubiquinol. As well to its endogenous synthesis, Coenzyme Q10 is also included in the diet. Dietary sources of CoQ10 are meat, poultry, fish, oil, and nuts. Coenzyme Q10 has an important role in energy metabolism in the mitochondria. It also protects the phospholipids, proteins, and DNA from oxidative damage in the membrane. It is stated that CoQ10 has several positive effects on diseases due to its antioxidant capacity. In recent years CoQ10 intake has become widespread. There are several studies investigating the usage and dosage of CoQ10 in diseases such as cardiovascular, neurological disease, diabetes, and reproductive endocrinology. In the present study, it was aimed to evaluate the CoQ10 and its possible health effects.

Keywords

Coenzyme Q10, dietary supplements, health, nutrition

References

1. Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012; 28:250-255.
2. Barakat A, Shegokar R, Dittgen M, Müller RH. Coenzyme Q10 oral bioavailability: effect of formulation type. Journal of Pharmaceutical Investigation 2013; 43:431-451.
3. O'Malley PA. The Past, Present, and Future of Coenzyme Q10 Supplementation Update for the Clinical Nurse Specialist. Clin Nurse Spec 2016; 30:15-16; quiz E10. 4. Chen F-P, Zhang N, Tang C-H. Food proteins as vehicles for enhanced water dispersibility, stability and bioaccessibility of coenzyme Q10. LWT - Food Science and Technology 2016; 72:125-133.
5. Cohen MM. Ubiquinol (Reduced Coenzyme Q10): A novel yet ubiquitous nutrient for heart disease. Journal of Advanced Nutrition and Human Metabolism 2015; 2.
6. Soni A, Verma, M. Kaushal, V., Ghalaut, VS. Coenzyme Q10 therapy in current clinical practice.International Journal of Research in Medical Sciences 2015; 3.
7. Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W. A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis.Complement Ther Med 2015; 23:789-793.
8. Prangthip P, Kettawan A, Posuwan J, Okuno M, Okamoto T. An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation.Journal of Dietary Supplements 2016; 13:647-659.
9. Yang YK, Wang LP, Chen L, Yao XP, Yang KQ, Gao LG, Zhou XL. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.Clin Chim Acta 2015; 450:83-89.
10. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis.J Clin Pharm Ther 2015; 40:413-418.
11. Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.Mol Neurobiol 2013; 48:883-903.
12. Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials.Atherosclerosis 2012; 221:311-316.
13. Alehagen U, Aaseth J. Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view.J Trace Elem Med Biol 2015; 31:157-162.
14. Garrido-Maraver J, Cordero, MD, Oropesa-Ávila, M, Vega AF, De La Mata M, Pavón AD, De Miguel M, Pérez Calero C, Paz MA, Cotán D, Sánchez-Alcázar JA. Coenzyme Q 10 Therapy.Mol Syndromol 2014; 5:187-197.
15. Potgieter M, Pretorius E, Pepper MS. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation.Nutr Rev 2013; 71:180-188.
16. Palamakula A SM, Khan MM. Regional permeability of coenzyme Q10 in isolated rat gastrointestinal tracts.Pharmazie 2005; 60:212-214.
17.http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm128219.htm
18. Yang S, Jensen MK, Mallick P, Rimm EB, Willett WC, Wu T. Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women.J Community Med Health Educ 2015; 5.
19. Trostchansky A, Quijano C, Yadav H, Kelley EE, Cassina AM. Interplay between Oxidative Stress and Metabolism in Signalling and Disease.Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity 2016.
20. Shen Q, Pierce, JD. Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus.Healthcare 2015 2015; 3:296-309.
21. Abdizadeh L, Jafari A, Armanfar M. Effects of short-term coenzyme Q10 supplementation on markers of oxidative stress and inflammation after downhill running in male mountaineers.Science & Sports 2015; 30:328-334.
22. Lee BJ, Tseng, YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.Nutrition Journal 2013; 12.
23. Ayer A, Macdonald P, Stocker R. CoQ10 Function and Role in Heart Failure and Ischemic Heart Disease.Annu Rev Nutr 2015; 35:175-213.
24. Turi A GS, Bruge F, Principi F, Battistoni S, Sntoni, F,Tranquilli AL, Littarru G, Tiano L. Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading.Arch Gynecol Obstet 2012; 285:1173-1176.
25. O'Brien HL, Kabbouche MA, Kacperski J, Hershey AD. Treatment of pediatric migraine.Curr Treat Options Neurol 2015; 17:326.
26. Greenlee H, Shaw J, Lau YK, Naini A, Maurer M. Lack of effect of coenzyme q10 on doxorubicin cytotoxicity in breast cancer cell cultures.Integr Cancer Ther 2012; 11:243-250.
27. Organization WH: http://www.who.int/mediacentre/factsheets/fs317/en/.
28. Pei H, Yang Y, Zhao H, Li X, Yang D, Li D, Yang Y. The Role ofMitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. 2016; ID 5470457:1-8.
29. Fotino AD, Thompson-Paul AM, Bazzano LA. Effect of coenzyme Q(1)(0) supplementation on heart failure: a meta-analysis.Am J Clin Nutr 2013; 97:268-275.
30. Choi HK, Won EK, Choung SY. Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats.Biomol Ther (Seoul) 2016; 24:171-177.
31. Taylor BA, Lorson L, White CM, Thompson PD. A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy.Atherosclerosis 2015; 238:329-335.
32. Rosenfeldt FL HS, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.J Hum Hypertens 2007; 21:297-306.
33. Atkin M, Light D, Cummşings MH. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial.Journal of Diabetes and Its Complications 2016; 30:723-727.
34. Ateş O, Bilen H, Keleş S, Alp HH, Keleş MS, Yıldırım K, Öndaş O, Pınar IC, Civelekler M, Baykal O. Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy.Int J Ophthalmol 2013; 6:675-679.
35. Montano SJ, Grünler J, Nair D, Tekle M, Fernandes AP, Hua X, Holmgren A, Brismar K, Ungerstedt JS. Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients.BBA Clinical 2015; 4:14-20.
36. Yang X, Dai G, Li G, Yang ES. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease.J Mol Neurosci 2010; 41:110-113.
37. Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S, Cohen BM, Renshaw PF. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.J Geriatr Psychiatry Neurol 2012; 25:43-50.
38. Mancuso M OD, Volpi L, Calsolaro V, Siciliano G. Coenzyme Q10 in neuromuscular and neurodegenerative disorders.Curr Drug Targets 2010; 11:111-121.
39. Li Z, Wang, P, Yu Z, Cong Y, Sun H, Zhang J, Zhang J, Sun C, Zhang Y, Ju X. The Effect of Creatine and Coenzyme Q10 Combination Therapy on Mild Cognitive Impairment in Parkinson’s Disease.Eur Neurol 2015; 73:205-211.
40. Gorgone G, Curro M, Ferlazzo N, Parisi G, Parnetti L, Belcastro V, Tambasco N, Rossi A, Pisani F, Calabresi P. Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson's disease patients.Neuromolecular Med 2012; 14:84-90.
41. Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson's disease.J Neurol Sci 2012; 318:72-75. 42. Investigators THSGPC. Safety and Tolerability of High-Dosage Coenzyme Q10 in Huntington’s Disease and Healthy Subjects.Movement Disorders 2010; 25:1924-1928. 43. Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review.Bipolar Disord 2012; 14:326-339.
44. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ, Lee KY. Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway.Neurotoxicology 2012; 33:85-90.
45. Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.J Alzheimers Dis 2011; 27:211-223.
46. Momiyama Y. Serum coenzyme Q10 levels as a predictor of dementia in a Japanese general population.Atherosclerosis 2014; 237:433-434. 47. Dhillon KS SJ, Lyall JS. Treatment of Clinical Cases of Migraine.Journal of Headache & Pain Management 2016; 1.
48. Daniel O, Mauskop A. Nutraceuticals in Acute and Prophylactic Treatment of Migraine.Curr Treat Options Neurol 2016; 18:14.
49. Rajapakse R PT. Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use.American Headache Society 2016.
50. Pucci E, Diamanti L, Cristina S, Antonaci F, Costa A. P032. Coenzyme Q-10 and migraine: a lovable relationship. The experience of a tertiary headache center.The Journal of Headache and Pain 2015; 16:A139.
51. Sándor PS DCL, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized, controlled trial.Neurology 2005; 64:716-715.
52. Neurology AAo. Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults.Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society 2012.
53. Society CH. <CanadianHeadacheSocietyGuidelineforMigraineProphylaxis.pdf>.The Journal Canadian Journal of Neurological Sciences 2012; 39.
54. Eapen A, Agarwal R, Thomas R, Sivaswamy L. Management of pediatric migraine in a tertiary care versus community based emergency department: an observational pilot study.Pediatr Neurol 2014; 50:164-170.
55. Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, Gomez C, Schmahmann J, Paulson H, Shakkottai VG. Coenzyme Q10 and spinocerebellar ataxias.Mov Disord 2015; 30:214-220.
56. Jones GT AF, Beasley M, Flu E, Sarzi-Puttini P, Macfarlane GJ. The Prevalence of Fibromyalgia in the General Population.Arthritis & Rheumatology 2015; 67:568-575. 57. <1990_Criteria_for_Classification_Fibro.pdf>.
58. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity.Arthritis Care Res (Hoboken) 2010; 62:600-610.
59. Alcocer-Gomez E, Cano-Garcia FJ, Cordero MD. Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review.Nutrition 2013; 29:1422-1425.
60. Cordero MD, Diaz-Parrado E, Carrion AM, Alfonsi S, Sanchez-Alcazar JA, Bullon P, Battino M, de Miguel M. Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?Antioxid Redox Signal 2013, 18:800-807.
61. Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y. Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.Redox Rep 2013; 18:12-19.
62. Bozkurt M, Oktayoglu P, Em S, Çaglayan M, Yuksel H, Uçar D, Batmaz İ, Sarıyıldız MA, Karatoprak S, Nas K. Serum Coenzyme Q10 Levels and Oxidative Status in Patients with Fibromyalgia Syndrome.Journal of Musculoskeletal Pain 2014; 22:27-32.
63. Alcocer-Gómez E S-AJ, Cordero M. Coenzyme Q10 Regulates Serotonin Levels and Depressive Symptoms in Fibromyalgia Patients: Results of a Small Clinical Trial.Journal of Clinical Psychopharmacology 2014; 34:277–278.
64. Jolliet P SN, Barré J, Pons JY, Boukef M, Paniel BJ, Tillement JP: Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences.J Clin Pharmacol Ther 1998, 36.
65. Cooney RV, Dai Q, Gao YT, Chow WH, Franke AA, Shu XO, Li H, Ji B, Cai Q, Chai W, Zheng W. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women.Cancer Epidemiol Biomarkers Prev 2011; 20:1124-1130.
66. Rusciani L, Proietti I, Rusciani A, Paradisi A, Sbordoni G, Alfano C, Panunzi S, De Gaetano A, Lippa S. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression.J Am Acad Dermatol 2006; 54:234-241.
67. Fouad AA, Al-Mulhim AS, Jresat I. Therapeutic effect of coenzyme Q10 against experimentally-induced hepatocellular carcinoma in rats.Environ Toxicol Pharmacol 2013; 35:100-108.
68. Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto CP, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study.Cancer Epidemiol Biomarkers Prev 2010; 19:2351-2356.
69. Teleman AA WC, Soffiani V, Poscia A, Di Pietro ML. Physical activity and health promotion in Italian university students.Ann Ist Super Sanità 2015, 51:106-110.
70. Del Pozo-Cruz J, Rodriguez-Bies E, Ballesteros-Simarro M, Navas-Enamorado I, Tung BT, Navas P, Lopez-Lluch G. Physical activity affects plasma coenzyme Q10 levels differently in young and old humans.Biogerontology 2014; 15:199-211.
71. Cooke M IM, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.Journal of the International Society of Sports Nutrition 2008; 5.
72. Kon M KF, Akimoto T, Tanabe K, Murase Y, Ikemune S, Kono I. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats.Immunology Review Exercise 2007; 13:76.
73. Lee HJ, Park MJ, Joo BS, Joo JK, Kim YH, Yang SW, Kim CW, Kim KH. Effects of coenzyme Q10 on ovarian surface epithelium-derived ovarian stem cells and ovarian function in a 4-vinylcyclohexene diepoxide-induced murine model of ovarian failure. Reprod Biol Endocrinol 2021; Apr 22;19(1):59.
74. Chavoshi Nezhad N, Vahabzadeh Z, Allahveisie A, Rahmani K, Raoofi A, Rezaie MJ, Rezaei M, Partovyan M. The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, before and after Freezing in Oligospermia Men. Urol J 2021; Feb 6;18(3):330-336.
75. Liu M, Zhu H, Hu X, Zhu Y, Chen H. Efficacy of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, and biomarkers of inflammation in women with polycystic ovary syndrome: A protocol for a systematic review and meta-analysis. Medicine (Baltimore) 2020;13;99(46):e23130.
76. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 2015;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26. PMID: 26111777; PMCID: PMC4568976.
77. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and nutritional factors in male (ın)fertility-underestimated factors. J Clin Med 2020; 9;9(5):1400. doi: 10.3390/jcm9051400.
78. Thakur, AS, Littarru, GP, Funahashi, I, Painkara, US, Dange, NS, Chauhan P. Effect of Ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. Journal of Clinical and Diagnostic Research: JCDR 2015; 9, BC01.
79. Safarinejad MR, Safarinejad SShafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q 10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. The Journal of Urology 2012; 188, 526-531.
80. Safarinejad MR. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. International Urology and Nephrology 2012; 44, 689-700.
81. Safarinejad, MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of Urology 2009; 182(1), 237-248.
82. Sharideh H, Zeinoaldini S, Zhandi M, Zaghari M, Sadeghi M, Akhlaghi A, Peebles ED. Use of supplemental dietary coenzyme Q10 to improve testicular function and fertilization capacity in aged broiler breeder roosters. Theriogenology 2020;15;142:355-362.
83. Romero S, Pella R, Zorrilla I, Berrío P, Escudero F, Pérez Y, García M, Gonzalez C, Orihuela P. Coenzyme Q10 improves the in vitro maturation of oocytes exposed to the intrafollicular environment of patients on fertility treatment. JBRA Assist ReprodN2020; 14;24(3):283-288.
84. Ma L, Cai L, Hu M, Wang J, Xie J, Xing Y, Shen J, Cui Y, Liu XJ, Liu J. Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies. Fertil Steril 2020;114(2):331-337. doi: 10.1016/j.fertnstert.2020.04.002. Epub 2020 Jul 7. PMID: 32646587.
85. Buhling K, Schumacher A, Eulenburg CZ, Laakmann E. Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reprod Biomed Online 2019;39(2):269-279.
86. Garolla A, Petre GC, Francini-Pesenti F, De Toni L, Vitagliano A, Di Nisio A, Foresta C. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 9;12(5):1472. 87. Ko EY, Sabanegh ES. The role of nutraceuticals in male fertility. Urologic Clinics 2014; 41(1), 181-193.
88. Çelebier M, Kaplan O, Özel Ş, Engin-Üstün, Y. Polycystic ovary syndrome in adolescents: Q-TOF LC/MS analysis of human plasma metabolome. Journal of Pharmaceutical and Biomedical Analysis, 2020; 191, 113543.
89. Doimo M, Desbats MA, Cerqua C, Cassina M, Trevisson E, Salviati L. Genetics of coenzyme q10 deficiency.Mol Syndromol 2014; 5:156-162.
90. Fernandez-Ayala DJ, Jimenez-Gancedo S, Guerra I, Navas P. Invertebrate models for coenzyme q10 deficiency.Mol Syndromol 2014; 5:170-179.
91. DiMauro S, Quinzii CM, Hirano M. Mutations in coenzyme Q 10 biosynthetic genes. The Journal of Clinical Investigation 2007; 117(3), 587-589.
92. Emmanuele V, Lopez LC, Berardo A, Naini A, Tadesse S, Wen B, D'Agostino E, Solomon M, DiMauro S, Quinzii C, Hirano M. Heterogeneity of coenzyme Q10 deficiency: patient study and literature review.Arch Neurol 2012; 69:978-983.
93. Desbats MA, Lunardi, G, Doimo M, Trevisson E, Salviati L. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency 2015, 38:145-156.
94. Montero R, Grazina M, Lopez-Gallardo E, Montoya J, Briones P, Navarro-Sastre A, Land JM, Hargreaves IP, Artuch R, Coenzyme QDSG: Coenzyme Q(1)(0) deficiency in mitochondrial DNA depletion syndromes.Mitochondrion 2013; 13:337-341.
95. Sacconi S, Trevisson E, Salviati L, Ayme S, Rigal O, Redondo AG, Mancuso M, Siciliano G, Tonin P, Angelini C. Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy.Neuromuscul Disord 2010; 20:44-48.
96. Yubero D, O'Callaghan M, Montero R, Ormazabal A, Armstrong J, Espinos C, Rodriguez MA, Jou C, Castejon E, Aracil MA. Association between coenzyme Q10 and glucose transporter (GLUT1) deficiency.BMC Pediatr 2014; 14:284.
97. Ercan P, Sedef EL. Koenzim Q10’un beslenme ve sağlık açısından önemi ve biyoyararlılığı. TÜBAV Bilim Dergisi 2010; 3(2), 192-200.
98. Ercan P, El SN. Changes in content of coenzyme Q10 in beef muscle, beef liver and beef heart with cooking and in vitro digestion.Journal of Food Composition and Analysis 2011; 24:1136-1140.
99. Hathcock JN, Shao, A. Risk assessment for coenzyme Q10 (Ubiquinone).Regulatory Toxicology and Pharmacology 2006; 45:282-288.
100. Yuting T, Tianli Y, Jinjin P, Yahong Y, Juhai L, Martin Lo Y. Effects of cell lysis treatments on the yield of coenzyme Q10 following Agrobacterium tumefaciens fermentation.Food Sci Technol Int 2010; 16:195-203.
101. Pravst I PM, Wondra AG, Zmitek K, Zmitek J. The Stability of Coenzyme Q10 in Fortified Foods.Acta Chimica Slovenica 2009, 56:953-958.
102. Castro-Marrero J, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Roman-Malo L, Aliste L, Fernandez de Sevilla T, Alegre J. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?Antioxid Redox Signal 2015; 22:679-685.
103. Sinatra ST, Jankowitz SN, Chopra RK, Bhagavan HN. Plasma Coenzyme Q10 and Tocopherols in Thoroughbred Race Horses: Effect of Coenzyme Q10 Supplementation and Exercise.Journal of Equine Veterinary Science 2014; 34:265-269.
104. Ferrante KL SJ, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.Neurology 2005; 13;65(11):1834-6 2005.
105. Yeung CK, Billings FT, Claessens AJ, Roshanravan B, Linke L, Sundell MB, Ahmad S, Shao B, Shen DD, Ikizler TA, Himmelfarb J. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.BMC Nephrology 2015; 16.
106. Pravst I, Žmitek K. The coenzyme Q10 content of food supplements.Journal für Verbraucherschutz und Lebensmittelsicherheit 2011; 6:457-463.

Koenzim Q10: Güncel Genel Bakış

Year 2022, , 77 - 86, 30.06.2022

Kadriye Erdoğan , Melahat Sedanur Macit , Nazlı Tunca Şanlıer Yaprak Ustun

https://doi.org/10.46969/EZH.1002286

Abstract

Koenzim Q10 (CoQ10), benzokinonlardan elde edilen lipitte çözünür bir bileşendir. Koenzim Q10’un oksitlenmiş formu ubiquinonedir ve indirgenmiş formu ubiquinoldür. Koenzim Q10, endojen sentezinin yanı sıra diyete de dâhildir. CoQ10’un diyet kaynakları et, kümes hayvanları, balık, yağ ve fındıktır. Koenzim Q10 in mitokondride enerji metabolizmasında önemli görevleri bulunmaktadır. Ayrıca membrandaki oksidatif hasardan fosfolipitleri, proteinleri ve DNA’yı korur. CoQ10’un antioksidan kapasitesi nedeniyle hastalıklar üzerinde birçok olumlu etkisi olduğu belirtilmektedir. Son yıllarda CoQ10 alımı yaygınlaştı. CoQ10’un kardiyovasküler, nörolojik hastalıklar, diyabet, kadın hastalıkları ve doğum vb. pek çok hastalıkta kullanım ve kullanım miktarını araştıran çalışmalar bulunmaktadır. Bu yazıda CoQ10 un metabolizması, etki mekanizmaları ile sağlık üzerine olan etkilerinin değerlendirilmesi amacıyla yapılmıştır.

Keywords

Koenzim Q10, diyet takviyeleri, sağlık, beslenme

References

1. Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012; 28:250-255.
2. Barakat A, Shegokar R, Dittgen M, Müller RH. Coenzyme Q10 oral bioavailability: effect of formulation type. Journal of Pharmaceutical Investigation 2013; 43:431-451.
3. O'Malley PA. The Past, Present, and Future of Coenzyme Q10 Supplementation Update for the Clinical Nurse Specialist. Clin Nurse Spec 2016; 30:15-16; quiz E10. 4. Chen F-P, Zhang N, Tang C-H. Food proteins as vehicles for enhanced water dispersibility, stability and bioaccessibility of coenzyme Q10. LWT - Food Science and Technology 2016; 72:125-133.
5. Cohen MM. Ubiquinol (Reduced Coenzyme Q10): A novel yet ubiquitous nutrient for heart disease. Journal of Advanced Nutrition and Human Metabolism 2015; 2.
6. Soni A, Verma, M. Kaushal, V., Ghalaut, VS. Coenzyme Q10 therapy in current clinical practice.International Journal of Research in Medical Sciences 2015; 3.
7. Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W. A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis.Complement Ther Med 2015; 23:789-793.
8. Prangthip P, Kettawan A, Posuwan J, Okuno M, Okamoto T. An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation.Journal of Dietary Supplements 2016; 13:647-659.
9. Yang YK, Wang LP, Chen L, Yao XP, Yang KQ, Gao LG, Zhou XL. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.Clin Chim Acta 2015; 450:83-89.
10. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis.J Clin Pharm Ther 2015; 40:413-418.
11. Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.Mol Neurobiol 2013; 48:883-903.
12. Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials.Atherosclerosis 2012; 221:311-316.
13. Alehagen U, Aaseth J. Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view.J Trace Elem Med Biol 2015; 31:157-162.
14. Garrido-Maraver J, Cordero, MD, Oropesa-Ávila, M, Vega AF, De La Mata M, Pavón AD, De Miguel M, Pérez Calero C, Paz MA, Cotán D, Sánchez-Alcázar JA. Coenzyme Q 10 Therapy.Mol Syndromol 2014; 5:187-197.
15. Potgieter M, Pretorius E, Pepper MS. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation.Nutr Rev 2013; 71:180-188.
16. Palamakula A SM, Khan MM. Regional permeability of coenzyme Q10 in isolated rat gastrointestinal tracts.Pharmazie 2005; 60:212-214.
17.http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm128219.htm
18. Yang S, Jensen MK, Mallick P, Rimm EB, Willett WC, Wu T. Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women.J Community Med Health Educ 2015; 5.
19. Trostchansky A, Quijano C, Yadav H, Kelley EE, Cassina AM. Interplay between Oxidative Stress and Metabolism in Signalling and Disease.Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity 2016.
20. Shen Q, Pierce, JD. Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus.Healthcare 2015 2015; 3:296-309.
21. Abdizadeh L, Jafari A, Armanfar M. Effects of short-term coenzyme Q10 supplementation on markers of oxidative stress and inflammation after downhill running in male mountaineers.Science & Sports 2015; 30:328-334.
22. Lee BJ, Tseng, YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.Nutrition Journal 2013; 12.
23. Ayer A, Macdonald P, Stocker R. CoQ10 Function and Role in Heart Failure and Ischemic Heart Disease.Annu Rev Nutr 2015; 35:175-213.
24. Turi A GS, Bruge F, Principi F, Battistoni S, Sntoni, F,Tranquilli AL, Littarru G, Tiano L. Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading.Arch Gynecol Obstet 2012; 285:1173-1176.
25. O'Brien HL, Kabbouche MA, Kacperski J, Hershey AD. Treatment of pediatric migraine.Curr Treat Options Neurol 2015; 17:326.
26. Greenlee H, Shaw J, Lau YK, Naini A, Maurer M. Lack of effect of coenzyme q10 on doxorubicin cytotoxicity in breast cancer cell cultures.Integr Cancer Ther 2012; 11:243-250.
27. Organization WH: http://www.who.int/mediacentre/factsheets/fs317/en/.
28. Pei H, Yang Y, Zhao H, Li X, Yang D, Li D, Yang Y. The Role ofMitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. 2016; ID 5470457:1-8.
29. Fotino AD, Thompson-Paul AM, Bazzano LA. Effect of coenzyme Q(1)(0) supplementation on heart failure: a meta-analysis.Am J Clin Nutr 2013; 97:268-275.
30. Choi HK, Won EK, Choung SY. Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats.Biomol Ther (Seoul) 2016; 24:171-177.
31. Taylor BA, Lorson L, White CM, Thompson PD. A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy.Atherosclerosis 2015; 238:329-335.
32. Rosenfeldt FL HS, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.J Hum Hypertens 2007; 21:297-306.
33. Atkin M, Light D, Cummşings MH. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial.Journal of Diabetes and Its Complications 2016; 30:723-727.
34. Ateş O, Bilen H, Keleş S, Alp HH, Keleş MS, Yıldırım K, Öndaş O, Pınar IC, Civelekler M, Baykal O. Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy.Int J Ophthalmol 2013; 6:675-679.
35. Montano SJ, Grünler J, Nair D, Tekle M, Fernandes AP, Hua X, Holmgren A, Brismar K, Ungerstedt JS. Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients.BBA Clinical 2015; 4:14-20.
36. Yang X, Dai G, Li G, Yang ES. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease.J Mol Neurosci 2010; 41:110-113.
37. Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S, Cohen BM, Renshaw PF. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.J Geriatr Psychiatry Neurol 2012; 25:43-50.
38. Mancuso M OD, Volpi L, Calsolaro V, Siciliano G. Coenzyme Q10 in neuromuscular and neurodegenerative disorders.Curr Drug Targets 2010; 11:111-121.
39. Li Z, Wang, P, Yu Z, Cong Y, Sun H, Zhang J, Zhang J, Sun C, Zhang Y, Ju X. The Effect of Creatine and Coenzyme Q10 Combination Therapy on Mild Cognitive Impairment in Parkinson’s Disease.Eur Neurol 2015; 73:205-211.
40. Gorgone G, Curro M, Ferlazzo N, Parisi G, Parnetti L, Belcastro V, Tambasco N, Rossi A, Pisani F, Calabresi P. Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson's disease patients.Neuromolecular Med 2012; 14:84-90.
41. Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson's disease.J Neurol Sci 2012; 318:72-75. 42. Investigators THSGPC. Safety and Tolerability of High-Dosage Coenzyme Q10 in Huntington’s Disease and Healthy Subjects.Movement Disorders 2010; 25:1924-1928. 43. Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review.Bipolar Disord 2012; 14:326-339.
44. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ, Lee KY. Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway.Neurotoxicology 2012; 33:85-90.
45. Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.J Alzheimers Dis 2011; 27:211-223.
46. Momiyama Y. Serum coenzyme Q10 levels as a predictor of dementia in a Japanese general population.Atherosclerosis 2014; 237:433-434. 47. Dhillon KS SJ, Lyall JS. Treatment of Clinical Cases of Migraine.Journal of Headache & Pain Management 2016; 1.
48. Daniel O, Mauskop A. Nutraceuticals in Acute and Prophylactic Treatment of Migraine.Curr Treat Options Neurol 2016; 18:14.
49. Rajapakse R PT. Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use.American Headache Society 2016.
50. Pucci E, Diamanti L, Cristina S, Antonaci F, Costa A. P032. Coenzyme Q-10 and migraine: a lovable relationship. The experience of a tertiary headache center.The Journal of Headache and Pain 2015; 16:A139.
51. Sándor PS DCL, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized, controlled trial.Neurology 2005; 64:716-715.
52. Neurology AAo. Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults.Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society 2012.
53. Society CH. <CanadianHeadacheSocietyGuidelineforMigraineProphylaxis.pdf>.The Journal Canadian Journal of Neurological Sciences 2012; 39.
54. Eapen A, Agarwal R, Thomas R, Sivaswamy L. Management of pediatric migraine in a tertiary care versus community based emergency department: an observational pilot study.Pediatr Neurol 2014; 50:164-170.
55. Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, Gomez C, Schmahmann J, Paulson H, Shakkottai VG. Coenzyme Q10 and spinocerebellar ataxias.Mov Disord 2015; 30:214-220.
56. Jones GT AF, Beasley M, Flu E, Sarzi-Puttini P, Macfarlane GJ. The Prevalence of Fibromyalgia in the General Population.Arthritis & Rheumatology 2015; 67:568-575. 57. <1990_Criteria_for_Classification_Fibro.pdf>.
58. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity.Arthritis Care Res (Hoboken) 2010; 62:600-610.
59. Alcocer-Gomez E, Cano-Garcia FJ, Cordero MD. Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review.Nutrition 2013; 29:1422-1425.
60. Cordero MD, Diaz-Parrado E, Carrion AM, Alfonsi S, Sanchez-Alcazar JA, Bullon P, Battino M, de Miguel M. Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?Antioxid Redox Signal 2013, 18:800-807.
61. Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y. Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.Redox Rep 2013; 18:12-19.
62. Bozkurt M, Oktayoglu P, Em S, Çaglayan M, Yuksel H, Uçar D, Batmaz İ, Sarıyıldız MA, Karatoprak S, Nas K. Serum Coenzyme Q10 Levels and Oxidative Status in Patients with Fibromyalgia Syndrome.Journal of Musculoskeletal Pain 2014; 22:27-32.
63. Alcocer-Gómez E S-AJ, Cordero M. Coenzyme Q10 Regulates Serotonin Levels and Depressive Symptoms in Fibromyalgia Patients: Results of a Small Clinical Trial.Journal of Clinical Psychopharmacology 2014; 34:277–278.
64. Jolliet P SN, Barré J, Pons JY, Boukef M, Paniel BJ, Tillement JP: Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences.J Clin Pharmacol Ther 1998, 36.
65. Cooney RV, Dai Q, Gao YT, Chow WH, Franke AA, Shu XO, Li H, Ji B, Cai Q, Chai W, Zheng W. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women.Cancer Epidemiol Biomarkers Prev 2011; 20:1124-1130.
66. Rusciani L, Proietti I, Rusciani A, Paradisi A, Sbordoni G, Alfano C, Panunzi S, De Gaetano A, Lippa S. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression.J Am Acad Dermatol 2006; 54:234-241.
67. Fouad AA, Al-Mulhim AS, Jresat I. Therapeutic effect of coenzyme Q10 against experimentally-induced hepatocellular carcinoma in rats.Environ Toxicol Pharmacol 2013; 35:100-108.
68. Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto CP, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study.Cancer Epidemiol Biomarkers Prev 2010; 19:2351-2356.
69. Teleman AA WC, Soffiani V, Poscia A, Di Pietro ML. Physical activity and health promotion in Italian university students.Ann Ist Super Sanità 2015, 51:106-110.
70. Del Pozo-Cruz J, Rodriguez-Bies E, Ballesteros-Simarro M, Navas-Enamorado I, Tung BT, Navas P, Lopez-Lluch G. Physical activity affects plasma coenzyme Q10 levels differently in young and old humans.Biogerontology 2014; 15:199-211.
71. Cooke M IM, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.Journal of the International Society of Sports Nutrition 2008; 5.
72. Kon M KF, Akimoto T, Tanabe K, Murase Y, Ikemune S, Kono I. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats.Immunology Review Exercise 2007; 13:76.
73. Lee HJ, Park MJ, Joo BS, Joo JK, Kim YH, Yang SW, Kim CW, Kim KH. Effects of coenzyme Q10 on ovarian surface epithelium-derived ovarian stem cells and ovarian function in a 4-vinylcyclohexene diepoxide-induced murine model of ovarian failure. Reprod Biol Endocrinol 2021; Apr 22;19(1):59.
74. Chavoshi Nezhad N, Vahabzadeh Z, Allahveisie A, Rahmani K, Raoofi A, Rezaie MJ, Rezaei M, Partovyan M. The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, before and after Freezing in Oligospermia Men. Urol J 2021; Feb 6;18(3):330-336.
75. Liu M, Zhu H, Hu X, Zhu Y, Chen H. Efficacy of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, and biomarkers of inflammation in women with polycystic ovary syndrome: A protocol for a systematic review and meta-analysis. Medicine (Baltimore) 2020;13;99(46):e23130.
76. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 2015;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26. PMID: 26111777; PMCID: PMC4568976.
77. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and nutritional factors in male (ın)fertility-underestimated factors. J Clin Med 2020; 9;9(5):1400. doi: 10.3390/jcm9051400.
78. Thakur, AS, Littarru, GP, Funahashi, I, Painkara, US, Dange, NS, Chauhan P. Effect of Ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. Journal of Clinical and Diagnostic Research: JCDR 2015; 9, BC01.
79. Safarinejad MR, Safarinejad SShafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q 10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. The Journal of Urology 2012; 188, 526-531.
80. Safarinejad MR. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. International Urology and Nephrology 2012; 44, 689-700.
81. Safarinejad, MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of Urology 2009; 182(1), 237-248.
82. Sharideh H, Zeinoaldini S, Zhandi M, Zaghari M, Sadeghi M, Akhlaghi A, Peebles ED. Use of supplemental dietary coenzyme Q10 to improve testicular function and fertilization capacity in aged broiler breeder roosters. Theriogenology 2020;15;142:355-362.
83. Romero S, Pella R, Zorrilla I, Berrío P, Escudero F, Pérez Y, García M, Gonzalez C, Orihuela P. Coenzyme Q10 improves the in vitro maturation of oocytes exposed to the intrafollicular environment of patients on fertility treatment. JBRA Assist ReprodN2020; 14;24(3):283-288.
84. Ma L, Cai L, Hu M, Wang J, Xie J, Xing Y, Shen J, Cui Y, Liu XJ, Liu J. Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies. Fertil Steril 2020;114(2):331-337. doi: 10.1016/j.fertnstert.2020.04.002. Epub 2020 Jul 7. PMID: 32646587.
85. Buhling K, Schumacher A, Eulenburg CZ, Laakmann E. Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reprod Biomed Online 2019;39(2):269-279.
86. Garolla A, Petre GC, Francini-Pesenti F, De Toni L, Vitagliano A, Di Nisio A, Foresta C. Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition. Nutrients 2020; 9;12(5):1472. 87. Ko EY, Sabanegh ES. The role of nutraceuticals in male fertility. Urologic Clinics 2014; 41(1), 181-193.
88. Çelebier M, Kaplan O, Özel Ş, Engin-Üstün, Y. Polycystic ovary syndrome in adolescents: Q-TOF LC/MS analysis of human plasma metabolome. Journal of Pharmaceutical and Biomedical Analysis, 2020; 191, 113543.
89. Doimo M, Desbats MA, Cerqua C, Cassina M, Trevisson E, Salviati L. Genetics of coenzyme q10 deficiency.Mol Syndromol 2014; 5:156-162.
90. Fernandez-Ayala DJ, Jimenez-Gancedo S, Guerra I, Navas P. Invertebrate models for coenzyme q10 deficiency.Mol Syndromol 2014; 5:170-179.
91. DiMauro S, Quinzii CM, Hirano M. Mutations in coenzyme Q 10 biosynthetic genes. The Journal of Clinical Investigation 2007; 117(3), 587-589.
92. Emmanuele V, Lopez LC, Berardo A, Naini A, Tadesse S, Wen B, D'Agostino E, Solomon M, DiMauro S, Quinzii C, Hirano M. Heterogeneity of coenzyme Q10 deficiency: patient study and literature review.Arch Neurol 2012; 69:978-983.
93. Desbats MA, Lunardi, G, Doimo M, Trevisson E, Salviati L. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency 2015, 38:145-156.
94. Montero R, Grazina M, Lopez-Gallardo E, Montoya J, Briones P, Navarro-Sastre A, Land JM, Hargreaves IP, Artuch R, Coenzyme QDSG: Coenzyme Q(1)(0) deficiency in mitochondrial DNA depletion syndromes.Mitochondrion 2013; 13:337-341.
95. Sacconi S, Trevisson E, Salviati L, Ayme S, Rigal O, Redondo AG, Mancuso M, Siciliano G, Tonin P, Angelini C. Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy.Neuromuscul Disord 2010; 20:44-48.
96. Yubero D, O'Callaghan M, Montero R, Ormazabal A, Armstrong J, Espinos C, Rodriguez MA, Jou C, Castejon E, Aracil MA. Association between coenzyme Q10 and glucose transporter (GLUT1) deficiency.BMC Pediatr 2014; 14:284.
97. Ercan P, Sedef EL. Koenzim Q10’un beslenme ve sağlık açısından önemi ve biyoyararlılığı. TÜBAV Bilim Dergisi 2010; 3(2), 192-200.
98. Ercan P, El SN. Changes in content of coenzyme Q10 in beef muscle, beef liver and beef heart with cooking and in vitro digestion.Journal of Food Composition and Analysis 2011; 24:1136-1140.
99. Hathcock JN, Shao, A. Risk assessment for coenzyme Q10 (Ubiquinone).Regulatory Toxicology and Pharmacology 2006; 45:282-288.
100. Yuting T, Tianli Y, Jinjin P, Yahong Y, Juhai L, Martin Lo Y. Effects of cell lysis treatments on the yield of coenzyme Q10 following Agrobacterium tumefaciens fermentation.Food Sci Technol Int 2010; 16:195-203.
101. Pravst I PM, Wondra AG, Zmitek K, Zmitek J. The Stability of Coenzyme Q10 in Fortified Foods.Acta Chimica Slovenica 2009, 56:953-958.
102. Castro-Marrero J, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Roman-Malo L, Aliste L, Fernandez de Sevilla T, Alegre J. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?Antioxid Redox Signal 2015; 22:679-685.
103. Sinatra ST, Jankowitz SN, Chopra RK, Bhagavan HN. Plasma Coenzyme Q10 and Tocopherols in Thoroughbred Race Horses: Effect of Coenzyme Q10 Supplementation and Exercise.Journal of Equine Veterinary Science 2014; 34:265-269.
104. Ferrante KL SJ, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.Neurology 2005; 13;65(11):1834-6 2005.
105. Yeung CK, Billings FT, Claessens AJ, Roshanravan B, Linke L, Sundell MB, Ahmad S, Shao B, Shen DD, Ikizler TA, Himmelfarb J. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.BMC Nephrology 2015; 16.
106. Pravst I, Žmitek K. The coenzyme Q10 content of food supplements.Journal für Verbraucherschutz und Lebensmittelsicherheit 2011; 6:457-463.

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Details

Primary Language	English
Subjects	Obstetrics and Gynaecology
Journal Section	Review Article
Authors	Kadriye Erdoğan 0000-0002-8789-1875 Melahat Sedanur Macit 0000-0002-7480-1586 Nazlı Tunca Şanlıer This is me 0000-0002-5059-4594 Yaprak Ustun 0000-0002-1011-3848
Publication Date	June 30, 2022
Acceptance Date	June 28, 2022
Published in Issue	Year 2022

Cite

APA	Erdoğan, K., Macit, M. S., Şanlıer, N. T., Ustun, Y. (2022). Coenzyme Q10: Current Overview. Türk Kadın Sağlığı Ve Neonatoloji Dergisi, 4(2), 77-86. https://doi.org/10.46969/EZH.1002286
AMA	Erdoğan K, Macit MS, Şanlıer NT, Ustun Y. Coenzyme Q10: Current Overview. Türk Kadın Sağlığı ve Neonatoloji Dergisi. June 2022;4(2):77-86. doi:10.46969/EZH.1002286
Chicago	Erdoğan, Kadriye, Melahat Sedanur Macit, Nazlı Tunca Şanlıer, and Yaprak Ustun. “Coenzyme Q10: Current Overview”. Türk Kadın Sağlığı Ve Neonatoloji Dergisi 4, no. 2 (June 2022): 77-86. https://doi.org/10.46969/EZH.1002286.
EndNote	Erdoğan K, Macit MS, Şanlıer NT, Ustun Y (June 1, 2022) Coenzyme Q10: Current Overview. Türk Kadın Sağlığı ve Neonatoloji Dergisi 4 2 77–86.
IEEE	K. Erdoğan, M. S. Macit, N. T. Şanlıer, and Y. Ustun, “Coenzyme Q10: Current Overview”, Türk Kadın Sağlığı ve Neonatoloji Dergisi, vol. 4, no. 2, pp. 77–86, 2022, doi: 10.46969/EZH.1002286.
ISNAD	Erdoğan, Kadriye et al. “Coenzyme Q10: Current Overview”. Türk Kadın Sağlığı ve Neonatoloji Dergisi 4/2 (June 2022), 77-86. https://doi.org/10.46969/EZH.1002286.
JAMA	Erdoğan K, Macit MS, Şanlıer NT, Ustun Y. Coenzyme Q10: Current Overview. Türk Kadın Sağlığı ve Neonatoloji Dergisi. 2022;4:77–86.
MLA	Erdoğan, Kadriye et al. “Coenzyme Q10: Current Overview”. Türk Kadın Sağlığı Ve Neonatoloji Dergisi, vol. 4, no. 2, 2022, pp. 77-86, doi:10.46969/EZH.1002286.
Vancouver	Erdoğan K, Macit MS, Şanlıer NT, Ustun Y. Coenzyme Q10: Current Overview. Türk Kadın Sağlığı ve Neonatoloji Dergisi. 2022;4(2):77-86.

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