Sistemik İnflamasyon Belirteçlerinin Foley Kateter ile Doğum İndüksiyon Başarısını Öngörmedeki Değeri
Abstract
Amaç: Sistemik inflamasyon belirteçlerinin foley kateter ile doğum indüksiyonu başarısını öngörmedeki değerini araştırmak.
Gereç ve Yöntem: Retrospektif kohort çalışmaya foley kateter ile doğum indüksiyonu uygulanan ≥ 37 hafta, tek, canlı, verteks geliş olan düşük riskli gebeler dahil edildi. Doğum indüksiyonu sonrası sezaryen ile doğumun gerçekleşmesi indüksiyon başarısızlığı olarak kabul edildi. Çalışma popülasyonu doğum indüksiyonu sonrası vajinal doğum yapanlar ve sezaryen doğum yapanlar olarak iki gruba ayrıldı. İki grubun demografik ve klinik özellikleri, prepartum tam kan sayımı değerleri, nötrofil/lenfosit oranı ve platelet/lenfosit oranı karşılaştırıldı.
Bulgular: Çalışmaya toplam 308 gebe dahil edildi. Olguların 159’unda (%51,6) doğum indüksiyonu sonrası vajinal yolla doğum gerçekleşirken, 149’unda (%48,4) sezaryen doğum ile gebelik sonlandı. Nulliparite oranı sezaryen ile doğum yapan olgularda (%68,5) vajinal yolla doğum yapanlara (%54,1) göre daha yüksek bulundu (p=0,01). Vajinal yolla doğum yapan ve sezaryen doğum gereksinimi olan olguların lökosit sayıları (9804,9 ± 3283,4 h/mm3’e karşı 10437,1 ± 4439,8 h/mm3), nötrofil/lenfosit oranı (4,7 ± 4,1’e karşı 4,4 ± 3,9) ve trombosit/lenfosit (149,3 ± 67,0’e karşı 139,3 ± 50,1) oranı arasında istatistiksel olarak anlamlı bir fark saptanmadı (p>0,05).
Sonuç: Doğum indüksiyonu öncesi bakılan sistemik inflamasyon belirteçleri ile doğum indüksiyon başarısı arasında anlamlı ilişki bulunmadı. Bununla birlikte nulliparitenin foley kateter ile doğum indüksiyon başarısızlığı için bir risk faktörü olduğu saptandı.
Keywords
Doğum indüksiyonu nulliparite sistemik inflamasyon belirteçi nötrofil/lenfosit oranı trombosit/lenfosit oranı
References
- Caughey AB, Sundaram V, Kaimal AJ, et al. Maternal and neonatal outcomes of elective induction of labour. Evidence report/technology assessment. 2009;176:1.
- Declercq ER, Sakala C, Corry MP, Applebaum S. Listening to mothers II: report of the second national US survey of women’s child bearing experiences: conducted January–February 2006 for childbirth connection by Harris Interactive® in partnership with Lamaze International. The Journal of perinatal education. 2007; 16: 9.
- Osterman MJ, Martin JA. Recent declines in induction of labor by gestational age. NCHS Data Brief. 2014;155:1-8.
- Seyb ST, Berka RJ, Socol ML, Dooley SL. Risk of cesarean delivery with elective induction of labor at term in nulliparous women. Obstet Gynecol. 1999;94:600-607.
- Laughon SK, Zhang J, Grewal J, Sundaram R, Beaver J, Reddy UM. Induction of labor in a contemporary obstetric cohort. Am J Obstet Gynecol. 2012;206:486.e1–486.e9.
- Vrouenraets FP, Roumen FJ, Dehing CJ, van den Akker ES, Aarts MJ, Scheve EJ. Bishop score and risk of cesarean delivery after induction of labor in nulliparous women. Obstet Gynecol. 2005;105:690-697.
- van der Ven AJ, vanOs MA, Kleinrouweler CE, et al. Midpregnancy Cervical Length in NulliparousWomen and its Association with Postterm Delivery and Intrapartum Cesarean Delivery. Am J Perinatol. 2016;33:40-46.
- Du YM, Zhu LY, Cui LN, Jin BH, Ou JL. Double-balloon catheter versus prostaglandin E2 for cervical ripening and labour induction: a systematic review and meta-analysis of randomised controlled trials. BJOG. 2017;124:891-899.
- Keirse MJNC. Endogenous prostaglandins in human parturition. In: Human Parturition, Keirse MJNC, Anderson ABM, Bennebroek-Gravenhorstm J (Eds), Leiden University Press, Leiden 1979. p.101.
- Casey ML, MacDonald PC. Biomolecular processes in the initiation of parturition: decidual activation. Clin Obstet Gynecol 1988; 31:533.
- Osmers RG, Bläser J, Kuhn W, Tschesche H. Interleukin-8 synthesis and the onset of labor. Obstet Gynecol 1995; 86:223
- Jiang S, He F, Gao R, et al. Neutrophil and Neutrophil-to-Lymphocyte Ratio as Clinically Predictive Risk Markers for Recurrent Pregnancy Loss. Reprod Sci. 2021;28:1101-1111
- Gogoi P, Sinha P, Gupta B, Firmal P, Rajaram S. Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int J Gynaecol Obstet. 2019;144:16-20
- Kolkman DG, Verhoeven CJ, Brinkhorst SJ, et al. The Bishop score as a predictor of labor induction success: a systematic review. Am J Perinatol. 2013;30:625-630
- Verhoeven CJ, Opmeer BC, Oei SG, Latour V, van der Post JA, Mol BW. Transvaginal sonographic assessment of cervical length and wedging for predicting outcome of labor induction at term: a systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2013;42:500-508.
- Zuckerman H, Reiss U, Rubinstein I. Inhibition of human premature labor by indomethacin. Obstet Gynecol 1974; 44:787.
- Unal ER, Cierny JT, Roedner C, Newman R, Goetzl L. Maternal inflammation in spontaneous term labor. Am J Obstet Gynecol 2011; 204:223.e1.
The Predictive Value of Systemic Inflammation Markers for the Success of Labor Induction with Foley Catheter
Abstract
Objective: To investigate the predictive value of systemic inflammatory markers for the success of labor induction with foley catheter.
Material and Method: Low-risk pregnancies with a single, live, vertex presentation at ≥37 weeks of gestation who underwent labor induction with a foley catheter were included in this retrospective cohort study. Delivery by cesarean section after labor induction was considered as induction failure. The study population was divided into two groups as those who delivered vaginally after labor induction and those who delivered by cesarean section. Demographic and clinical characteristics, prepartum complete blood count values, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio of the two groups were compared.
Results: A total of 308 pregnant women were included in the study. Vaginal delivery was performed in 159 (51.6%) of the cases after labor induction, while pregnancy was terminated by cesarean section in 149 (48.4%) cases. The rate of nulliparity was found to be higher in cases who delivered by cesarean section (68.5%) than those who delivered vaginally (54.1%) (p = 0.01). There was no statistically significant difference between leukocyte counts (9804.9 ± 3283.4 h/mm3 vs. 10437.1 ± 4439.8 h/mm3), neutrophil/lymphocyte ratio (4.7 ± 4.1 vs. 4.4 ± 3.9) and platelet/lymphocyte ratio (149.3 ± 67.0 vs. 139.3 ± 50.1) of cases who delivered vaginally and required cesarean delivery (p>0.05).
Conclusion: There was no significant relationship between systemic inflammation markers measured before labor induction and labor induction success. However, nulliparity was found to be a risk factor for the failure of labor induction with foley catheter.
Keywords
Labor induction nulliparity systemic inflammatory markers neutrophil/lymphocyte ratio platelet/lymphocyte ratio
References
- Caughey AB, Sundaram V, Kaimal AJ, et al. Maternal and neonatal outcomes of elective induction of labour. Evidence report/technology assessment. 2009;176:1.
- Declercq ER, Sakala C, Corry MP, Applebaum S. Listening to mothers II: report of the second national US survey of women’s child bearing experiences: conducted January–February 2006 for childbirth connection by Harris Interactive® in partnership with Lamaze International. The Journal of perinatal education. 2007; 16: 9.
- Osterman MJ, Martin JA. Recent declines in induction of labor by gestational age. NCHS Data Brief. 2014;155:1-8.
- Seyb ST, Berka RJ, Socol ML, Dooley SL. Risk of cesarean delivery with elective induction of labor at term in nulliparous women. Obstet Gynecol. 1999;94:600-607.
- Laughon SK, Zhang J, Grewal J, Sundaram R, Beaver J, Reddy UM. Induction of labor in a contemporary obstetric cohort. Am J Obstet Gynecol. 2012;206:486.e1–486.e9.
- Vrouenraets FP, Roumen FJ, Dehing CJ, van den Akker ES, Aarts MJ, Scheve EJ. Bishop score and risk of cesarean delivery after induction of labor in nulliparous women. Obstet Gynecol. 2005;105:690-697.
- van der Ven AJ, vanOs MA, Kleinrouweler CE, et al. Midpregnancy Cervical Length in NulliparousWomen and its Association with Postterm Delivery and Intrapartum Cesarean Delivery. Am J Perinatol. 2016;33:40-46.
- Du YM, Zhu LY, Cui LN, Jin BH, Ou JL. Double-balloon catheter versus prostaglandin E2 for cervical ripening and labour induction: a systematic review and meta-analysis of randomised controlled trials. BJOG. 2017;124:891-899.
- Keirse MJNC. Endogenous prostaglandins in human parturition. In: Human Parturition, Keirse MJNC, Anderson ABM, Bennebroek-Gravenhorstm J (Eds), Leiden University Press, Leiden 1979. p.101.
- Casey ML, MacDonald PC. Biomolecular processes in the initiation of parturition: decidual activation. Clin Obstet Gynecol 1988; 31:533.
- Osmers RG, Bläser J, Kuhn W, Tschesche H. Interleukin-8 synthesis and the onset of labor. Obstet Gynecol 1995; 86:223
- Jiang S, He F, Gao R, et al. Neutrophil and Neutrophil-to-Lymphocyte Ratio as Clinically Predictive Risk Markers for Recurrent Pregnancy Loss. Reprod Sci. 2021;28:1101-1111
- Gogoi P, Sinha P, Gupta B, Firmal P, Rajaram S. Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int J Gynaecol Obstet. 2019;144:16-20
- Kolkman DG, Verhoeven CJ, Brinkhorst SJ, et al. The Bishop score as a predictor of labor induction success: a systematic review. Am J Perinatol. 2013;30:625-630
- Verhoeven CJ, Opmeer BC, Oei SG, Latour V, van der Post JA, Mol BW. Transvaginal sonographic assessment of cervical length and wedging for predicting outcome of labor induction at term: a systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2013;42:500-508.
- Zuckerman H, Reiss U, Rubinstein I. Inhibition of human premature labor by indomethacin. Obstet Gynecol 1974; 44:787.
- Unal ER, Cierny JT, Roedner C, Newman R, Goetzl L. Maternal inflammation in spontaneous term labor. Am J Obstet Gynecol 2011; 204:223.e1.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 30, 2022 |
| Acceptance Date | May 20, 2022 |
| Published in Issue | Year 2022 |