Postmenapozal Hastalarda Trombosit Hacmi, Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Vücut Kitle İndeksine Göre Karşılaştırılması ve Bu Sonuçların Kardiyovasküler Risk ve Sıcak Basması Üzerine Etkileri

Year 2022, , 70 - 76, 30.06.2022

Mehmet Alican Sapmaz , İlknur Sayar , Ece Yiğit , Tuncay Küçüközkan

https://doi.org/10.46969/EZH.1111908

Abstract

Amaç: Postmenopozal dönemindeki kadınlarda nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin kardiyovasküler riski öngören birer belirteç olup olmadıklarının tespit edilmesi hedeflenmiştir.
Gereç ve Yöntem: Kardiyovasküler hastalığı olmayan, postmenapozal dönemindeki hastalar çalışmamıza dahil edilmiştir. Boy ve kilo ölçümleri yapılarak vücut kitle indeksleri hesaplanmış, hemogram ve lipid profili analizleri yapılmış ve karotis intima kalınlıkları ölçülmüştür. Bu değerlere göre kardiyovasküler riski yüksek olan grup ve düşük olan grup arasında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacmi değerleri açısından anlamlı farklılık olup olmadığı analiz edilmiştir.
Bulgular: Çalışmamıza 158 kadın hasta dahil edilmiştir. Vücut kitle indexi ≥30 olan grubun total kolesterol, trigliserid, düşük yoğunluklu lipoprotein ve lenfosit düzeyi ve ayrıca bilateral karotis intima kalınlıkları anlamlı olarak daha yüksek bulunmuştur. İki grup arasında nötrofil sayısı, trombosit sayısı, ortalama trombosit hacmi, nötrofil/lenfosit oranı ve yüksek dansiteli lipoprotein düzeyleri açısından anlamlı farklılık tespit edilemezken, trombosit/lenfosit oranı VKİ ≥30 olan grupta daha düşük bulunmuştur.
Sonuç: Çalışmamızda kardiyovasküler hastalığı olmayan postmenopozal dönemdeki hastalar kardiyovasküler hastalık gelişimi açısından yüksek ve düşük riskli olarak ikiye ayrılarak kıyaslanmıştır. Çalışmanın sonucu bu inflamatuar belirteçlerin henüz hastalık tablosu ortaya çıkmamış hastalarda risk öngörmede anlamlı belirteçler olmadığını göstermiştir.

Keywords

Menopoz, inflamasyon, kardiyovasküler hastalıklar

Comparison of Thrombocyte Volume, Thrombocyte/Lymphocyte and Neutrophil/Lymphocyte Ratios According to Body Mass Index in Postmenopausal Patients and The Effect of These Results On Cardiovascular Risk and Hot Flashes

Abstract

Aim: It was aimed to determine whether neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume are predictors of cardiovaskular risk in postmenopausal women.
Material and Method: Postmenopausal patients without cardiovascular disease were included in our study. Body mass indexes were calculated by measuring height and weight, hemogram and lipid profile analyzes were made and carotid intima thickness was measured. According to these values, it was analyzed whether there was a significant difference between the group with high cardiovascular risk and the group with low risk in terms of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume values.
Results: 158 female patients were included in our study. Total cholesterol, triglyceride, low density lipoprotein and lymphocyte levels as well as bilateral carotid intima thicknesses were found to be significantly higher in the group with a body mass index of ≥30. While there was no significant difference between the two groups in terms of neutrophil count, platelet count, mean platelet volume, neutrophil/lymphocyte ratio and high-density lipoprotein levels, the platelet/lymphocyte ratio was found to be lower in the group with BMI ≥30.
Conclusion: In our study postmenopausal patients without cardiovascular disease were divided into two groups as high and low risk for the development of cardiovascular disease and compared. The result of the study showed that these inflammatory markers are not significant markers in predicting risk in patients who have not yet manifested the disease.

Keywords

Menapause, inflammation, cardiovascular diseases

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