Does Obestatin Level Change in Endometrial Pathologies? A Case-Control Study in A Tertiary Care Hospital

Year 2022, , 110 - 115, 22.09.2022

Tuba Memur , Nagihan Cengaver , Canan Tapkan , Müjde Can İbanoğlu , Burçin Salman Özgü , Tayfun Güngör

https://doi.org/10.46969/EZH.1139281

Abstract

Background: The rising incidence of endometrial cancer has been associated with increases in obesity and physical inactivity. We investigated the clinical significance of serum obestatin levels in women with endometrial cancer, endometrial hyperplasia, and age-matched healthy controls.
Material and Methods: The present study was a case-control study conducted at a single center between May 2014 and July 2015. The medical records of 90 patients with a final histopathologic diagnosis after therapeutic curettage for abnormal uterine bleeding were reviewed and categorized by diagnosis. The study population included women with adenocarcinoma of the endometrium (n= 33), hyperplasia of the endometrium (n= 27), and proliferative endometrium (n=30) according to histopathological diagnosis. The women with proliferative endometrium formed the control group.
Results: Endometrial cancer was diagnosed in 33 (36.6%) of the patients who presented to our clinic for abnormal uterine bleeding. In the group with endometrial cancer, the mean age was 55.2 ± 8.6 years. There were no differences in obestatin levels between groups (p > 0.05). In the ROC curve analysis, the area under the curve value was 0.574, and obestatin did not prove to be a significant marker for cancer prediction in the population involved in the study.
Conclusion: This study did not demonstrate a clear association between circulating levels of obestatin and endometrial pathologies.

Keywords

Obestatin, endometrial cancer, endometrial hyperplasia, obesity

Endometrial Patolojilerde Obestatin Düzeyi Değişir Mi? Üçüncü Basamak Hastanede Bir Vaka Kontrol Çalışması

Abstract

Amaç: Artan endometriyal kanser insidansı, obezite ve fiziksel hareketsizlikteki artışlarla ilişkilendirilmiştir. Bu bilgiden yola çıkarak, endometriyal kanserli, endometriyal hiperplazili kadınlarda ve aynı yaştaki sağlıklı kontrollerde serum obestatin düzeylerinin klinik önemini araştırdık.
Gereç ve Yöntem: Bu çalışma Mayıs 2014-Temmuz 2015 tarihleri arasında tek merkezde yürütülen bir vaka-kontrol çalışmasıdır. Anormal uterin kanamaya yönelik terapötik küretaj sonrası kesin histopatolojik tanısı konulan 90 hastanın tıbbi kayıtları incelenmiş ve tanılarına göre kategorize edilmiştir. Çalışma popülasyonu, histopatolojik tanıya göre endometrium adenokarsinomu (n= 33), endometrium hiperplazisi (n=27) ve proliferatif endometrium (n=30) olan kadınları içermiştir. Kontrol grubunu ise proliferatif endometriumlu kadınlar oluşturdu.
Bulgular: Kliniğimize anormal uterin kanama ile başvuran hastaların 33’ünde (%36,6) endometrium kanseri tanısı konuldu. Endometrium kanserli grupta yaş ortalaması 55.2 ± 8.6 yıl idi. Gruplar arasında obestatin seviyelerinde fark yoktu (p > 0.05). ROC eğrisi analizinde, eğrinin altında kalan alan değeri 0,574 idi ve obestatin, çalışmaya dahil edilen popülasyonda kanser tahmini için önemli bir belirteç olduğunu kanıtlamadı.
Sonuç: Bu çalışma, dolaşımdaki obestatin seviyeleri ile endometriyal patolojiler arasında net bir ilişki göstermedi.

Keywords

Obestatin, endometriyal kanser, endometriyal hiperplazi, obezite

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